Table 1 Blood pressure and heart rate changes induced by atropine ( i.v., 0.03 mg/kg ) between sham-operated and 2K1C rats (n = 6)
From: Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats
Sham | 2K1C | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Pre-atropine | Post-atropine | Pre-atropine | Post-atropine | ||||||
4 weeks | SBP (mmHg) | 107± | 2.1 | 108± | 2.2 | 161± | 8.5 * | 163± | 7.8 |
DBP(mmHg) | 78± | 3.8 | 82± | 3.7 | 102± | 3.7 * | 105± | 3.1 | |
HR (beat/min) | 342± | 8.6 | 405± | 6.8 ## | 380± | 16.4 | 422± | 15.6 # | |
8 weeks | SBP (mmHg) | 105± | 1.3 | 109± | 1.6 | 155± | 4.3 * | 156± | 5.5 |
DBP(mmHg) | 70± | 1.9 | 73± | 1.3 | 105± | 6.2 * | 107± | 6.8 | |
HR (beat/min) | 332± | 4.4 | 395± | 5.6 ## | 336± | 9.3 | 369± | 9.3 # | |
20 weeks | SBP (mmHg) | 106± | 1.1 | 108± | 1.1 | 174± | 4.2 * | 176± | 2.8 |
DBP(mmHg) | 72± | 1.0 | 72± | 1.3 | 109± | 2.8 * | 110± | 2.0 | |
HR (beat/min) | 335± | 6.8 | 388± | 8.9 ## | 345± | 6.2 | 377± | 8.8 # | |