ACE gene insertion/deletion polymorphism has a mild influence on the acute development of left ventricular dysfunction in patients with ST elevation myocardial infarction treated with primary PCI

Table 3 Multivariate models for adjusting of parameters of left ventricle dysfunction

	Ejection fraction (echo)	Ejection fraction (angiography)	EDV/BSA	ESV/BSA1	BNP1	BNP2	NT-pro BNP1	NT-pro BNP2
Age	-	-	-	-	< 0.001	< 0.001	< 0.001	< 0.001
Sex (Women)	-	-	0.001	0.003	0.004	< 0.001	< 0.001	< 0.001
BMI	-	-	-	-	-	-	0.017	-
Diabetes mellitus	0.336	-	0.140	0.067	-	-	-	-
Previous instability	-	-	-	-	0.037	-	< 0.001	0.001
Infarction	< 0.001	0.001	< 0.001	< 0.001	-	-	-	-
Betablocators	-	-	-	-	< 0.001	-	0.002	-
Creatinine3	0.004	< 0.001	-	-	< 0.001	< 0.001	< 0.001	< 0.001
IRA - RIA	< 0.001	< 0.001	-	0.010	-	< 0.001	-	< 0.001
DCV	0.001	-	-	0.007	0.260	0.005	0.011	0.002
Time delay (min)	0.003	< 0.001	-	-	< 0.001	0.069	< 0.001	0.002
R²	17.3%	18.6%	5.7%	9.0%	26.9%	31.6%	42.0%	42.7%

Statistical significance of relationship was analyzed by means of linear regression; parameters ESV/BSA, BNP and NT-proBNP were log transformed prior to analysis. R² stands for variability explained by given model.
EDV: end-diastolic volume; ESV: end-systolic volume; BSA: Body surface area; BMI: Body mass index; IRA: infarct-related artery; DCV: Diseased coronary vessels

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