Mechanical thrombectomy of COVID-19 DVT with congenital heart disease leading to phlegmasia cerulea dolens: a case report

Background COVID-19 and Fontan physiology have each been associated with an elevated risk of venous thromboembolism (VTE), however little is known about the risks and potential consequences of having both. Case presentation A 51 year old male with tricuspid atresia status post Fontan and extracardiac Glenn shunt, atrial flutter, and sinus sick syndrome presented with phlegmasia cerulea dolens (PCD) of the left lower extremity in spite of supratherapeutic INR in the context of symptomatic COVID-10 pneumonia. He was treated with single session, catheter directed mechanical thrombectomy that was well-tolerated. Conclusions This report of acute PCD despite therapeutic anticoagulation with a Vitamin K antagonist, managed with emergent mechanical thrombectomy, calls to attention the importance of altered flow dynamics in COVID positive patients with Fontan circulation that may compound these independent risk factors for developing deep venous thrombosis with the potential for even higher morbidity.


Background
COVID-associated coagulopathy has recently been described [1] and COVID VTE is recognized to be significantly elevated in critically ill patients [2][3][4]. Patients with altered Fontan physiology have independently elevated risks of developing VTE due to decreased pulmonary arterial pressures. Meta-analyses are now reporting risk factors for DVT development including hypoalbuminemia and higher Sequential Organ Failure Assessment (SOFA) scores [5]. However the risk for VTE in the context of altered cardiopulmonary circulation due to congential heart disease (CHD) remains largely unknown.

Case presentation
A 51-year-old male with tricuspid atresia, status post atriopulmonary Fontan at 6 years of age with subsequent urgent surgical conversion to an extracardiac Fontan ( Fig. 1) in the setting of a right atrial thrombus at 30 years of age. The patient initially presented to an outpatient clinic with cough and diarrhea. He was diagnosed with SARS-CoV-2 infection via nasopharyngeal swab. Six days later, he presented to a rural emergency room with progressive exertional dyspnea, and was found to be hypoxic and hypotensive. He was diagnosed with COVID-19 pneumonia (Fig. 2), the patient was placed on bilevel positive airway pressure (BiPAP) and vasopressor support. He received a course of remdesivir and was continued on tadalafil. Warfarin was held due to a supratherapeutic international normalized ratio (INR) greater than 14. His respiratory status improved and he was weaned to a non-rebreather mask. He developed bilateral leg pain during the hospitalization, and lower extremity venous ultrasound detected bilateral deep vein thromboses. Given these findings, he was urgently transferred to our institution on hospital day (HD) 7 for higher level of care (Table 1).
Upon transfer, his INR was down-trending, but remained supratherapeutic at 6.6, and computed tomography venogram (CTV) demonstrated bilateral deep venous thrombosis from the iliac to calf veins, excluding the inferior vena cava (IVC). There was no evidence of pulmonary embolus. Physical exam was notable left lower leg findings pitting edema, purple discoloration (Figs. 3, 4), decreased sensation, and mobility. The laboratory workup was notable in particular for the supratherapeutic INR that was reduced to 1.6 by the second day of hospitalization at our institution, following treatment with Vitamin K. DIC panel and prothrombotic workup, including β-2 glycoprotein and cardiolipin antibodies, were negative ( Table 2).  While the differential diagnosis of limb ischemia in the setting of COVID-19 infection includes arterial thrombosis, the demonstration of venous outflow obstruction (Fig. 4), violaceous discoloration of the lower extremity, pronounced edema, and pain confirmed the diagnosis of phlegmasia cerulea dolens (PCD). A heparin drip was initiated with vitamin K reversal of warfarin. Since his partial thromboplastin time (PTT) values were abnormal (Table 2), anti-Xa levels were used to titrate the heparin infusion. He also received convalescent plasma [6]. Arterial Doppler was notable for biphasic waveforms with excessive diastolic reversed flow concerning for developing compartment syndrome, without evidence of arterial thrombosis.
Following multidisciplinary evaluation, the decision was made undergo an emergent transvenous thrombectomy to salvage the left leg. Given the inflammatory nature of the clot and development of PCD in spite Table 1 Timeline for the key events from initial presentation, hospitalization, and transfer to our institution OSHD Outside Hospital Day, HD Hospital Day (our institution)  Color-rendered 3D reconstruction of the pelvis outlining the patent arterial vasculature (aorta and bilateral iliac arteries) and IVC with bilateral venous thromboses. The white, green, and blue arrows indicate the abrupt completely occlusive thrombus of the proximal left common iliac vein, the occlusive thrombus of the right common femoral vein, and the iliac confluence into the IVC, respectively of supratherapeutic INR, mechanical thrombectomy was felt to be the most appropriate course of action [7] as opposed to 'lyse and wait' strategies that could prolong vascular compromise and also subject the patient to increased adverse bleeding events and the potential development of compartment syndrome. Bilateral popliteal vein access was obtained for catheter directed mechanical thrombectomy using the Clot-Triever ® system (Inari Medical). Popliteal and Fontan pressures were 19 and 17 mmHg, respectively; pulmonary angiography did not demonstrate any emboli. Five thrombectomy passes of the left lower extremity from the popliteal vein to the IVC and four passes of the right leg successfully restored flow from the bilateral popliteal veins to the IVC (Fig. 5) and yielded thrombus that was positive for SARS-CoV-2 by polymerase chain reaction (PCR). In order to protect the cardiopulmonary circulation peri-procedurally during anticoagulation optimization, bilateral retrievable iliac vein filters (Optease) were placed. An IVC filter was not placed due to the large size of the cava. The iliac filters were retrieved on HD 12 via femoral approach (the right internal jugular vein was chronically occluded) following venograms confirming patent femoral and iliac veins. A left lower extremity cellulitis developed and empirically managed with antibiotics. The patient unfortunately did not have reversal of the ischemic changes post-procedure, requiring below-theknee amputation (BKA) for dry gangrene of the left foot.

Day 1 Patient presentation to outpatient clinic with upper respiratory and gastrointestinal symptoms, diagnosed with SARS-CoV-2 infection via nasopharyngeal swab
He experienced epistaxis while on heparin, that was treated with nasal packing. There was evidence of postpneumonia fibrosis [8] (Fig. 2C and 2D); the associated increase in pulmonary vascular resistance is often not well tolerated in Fontan patients [9]. His tadalafil was increased to 40 mg daily from 20 mg daily to improve hemodynamics. His oxygen saturation was eventually maintained on room air and he never required mechanical ventilation. The BKA was well tolerated and on HD 50 he was discharged to an acute rehabilitation unit on warfarin.

Discussion and conclusions
Patients with a Fontan circulation are at higher risk for thrombus formation [10]. The systemic venous return drains directly into the pulmonary arteries, and the lack of a subpulmonary ventricle results in a low-flow state through the pulmonary arterial circuit. Pulmonary venous return thus depends on negative inspiratory intrathoracic pressure, low pulmonary vascular resistance, and diastolic function of the systemic ventricle. Increases in pulmonary vascular resistance due to pulmonary infections, positive-pressure ventilation, and/or atrial arrhythmias can all decrease pulmonary blood flow [10,11]. Patients with COVID-19 infection are at higher risk for thrombosis due to multiple theorized factors, including an increased inflammatory state and endothelial cell dysfunction secondary to viral invasion [12,13]. PCD in patients with COVID-19 has been reported [1], but thus far only in patients predisposed to thrombosis. In our case, our patient's cardiac anatomy and physiology placed him in a higher risk category, and despite treatment with a vitamin K antagonist with supratherapeutic levels, he developed extensive bilateral venous thromboses. Interestingly his pulmonary circulation was intact and he did not develop any evidence of pulmonary emboli on CTA or pulmonary angiography. PCD requires aggressive therapy for limb salvage [14], but resource limitations in heavily impacted hospitals during the COVID pandemic may result in delays in diagnosis and treatment. Nevertheless, the treatment this patient received likely prevented further leg ischemia and limited his amputation to below-the-knee instead of above-the-knee, which is associated with improved functionality and long-term outcomes [15].
Presently, the most effective anticoagulation strategy for patients with COVID-19 related thrombosis is unclear. Our patient developed no further thrombosis while on heparin, though notably this change was made after the COVID pneumonia was already improving.

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Ready to submit your research Ready to submit your research ? Choose BMC and benefit from: ? Choose BMC and benefit from: Patients with comorbidities that place them in higherrisk categories for various disease states, such as Fontan circulation, are potentially at higher risk of complications from COVID-19. PCD is a rare but devastating complication, and must be recognized early and treated aggressively; mechanical thrombectomy may be indicated to expedite restoration of venous outflow, particularly when anticoagulation may be contraindicated. Pulmonary fibrosis secondary to COVID-19 may lead to increased pulmonary vascular resistance, which may further complicate the long-term course of Fontan patients in particular. Despite the presence of acute lung injury and extensive deep venous thromboses, our patient did not require mechanical ventilation or develop decompensated heart failure, reflecting a reassuring degree of resilience of this patient's Fontan circulation in the face of COVID-19 infection.