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  2. Cytochrome P450 (CYP) enzyme 2J2, an epoxygenase predominantly expressed in the heart, metabolises arachidonic acid to biologically active eicosanoids. One of the CYP2J2 products, 11, 12-epoxyeicosatrienoic ac...

    Authors: Jan Börgel, Daniel Bulut, Christoph Hanefeld, Horst Neubauer, Andreas Mügge, Jörg T Epplen, Tim Holland-Letz and Martin Spiecker

    Citation: BMC Cardiovascular Disorders 2008 8:41

    Content type: Research article

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  3. The alpha1A-adrenergic receptor (α1A-AR) regulates the cardiac and peripheral vascular system through sympathetic activation. Due to its important role in the regulation of vascular tone and blood pressure, we ai...

    Authors: Silvia R Freitas, Alexandre C Pereira, Marcilene S Floriano, José G Mill and José E Krieger

    Citation: BMC Cardiovascular Disorders 2008 8:40

    Content type: Research article

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  4. Enhanced external counter pulsation (EECP) is a non-invasive treatment option for patients with refractory angina pectoris ineligible to further traditional treatment. The aim of this study was to evaluate the...

    Authors: André Erdling, Susanne Bondesson, Thomas Pettersson and Lars Edvinsson

    Citation: BMC Cardiovascular Disorders 2008 8:39

    Content type: Research article

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  5. Coronary artery calcification (CAC) measured by electron-beam computed tomography (EBCT) has been well studied in the prediction of coronary artery disease (CAD). We sought to evaluate the impact of the CAC sc...

    Authors: Lieuwe H Piers, Farah Salachova, Riemer HJA Slart, Rozemarijn Vliegenthart, Riksta Dikkers, Frederique AP Hospers, Hjalmar R Bouma, Clark J Zeebregts, Tineke P Willems, Matthijs Oudkerk, Felix Zijlstra and René A Tio

    Citation: BMC Cardiovascular Disorders 2008 8:38

    Content type: Research article

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  6. The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are impor...

    Authors: Erik Ingelsson, Louise Bennet, Martin Ridderstråle, Marianne Söderström, Lennart Råstam and Ulf Lindblad

    Citation: BMC Cardiovascular Disorders 2008 8:37

    Content type: Research article

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  7. Endothelial dysfunction plays a central role in atherosclerotic progression and cardiovascular complications of type 2 diabetes mellitus (T2DM). Given the role of nitric oxide in the vascular system, we aimed ...

    Authors: Jacob Odeberg, Charlotte A Larsson, Lennart Råstam and Ulf Lindblad

    Citation: BMC Cardiovascular Disorders 2008 8:36

    Content type: Research article

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  8. Anoxic coma following cardiac arrest is a common problem with ethical, social, and legal consequences. Except for unfavorable somatosensory-evoked potentials (SSEP) results, predictors of unfavorable outcome w...

    Authors: Cédric Daubin, Damien Guillotin, Olivier Etard, Cathy Gaillard, Damien du Cheyron, Michel Ramakers, Bruno Bouchet, Jean-Jacques Parienti and Pierre Charbonneau

    Citation: BMC Cardiovascular Disorders 2008 8:35

    Content type: Research article

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  9. Few studies have addressed whether the combined use of B-type natriuretic peptide (BNP) and high-sensitive C-reactive protein (hsCRP) improves risk stratification for mortality and cardiovascular events in a p...

    Authors: Trygve Brügger-Andersen, Volker Pönitz, Harry Staines, David Pritchard, Heidi Grundt and Dennis WT Nilsen

    Citation: BMC Cardiovascular Disorders 2008 8:34

    Content type: Research article

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  10. Most studies documenting beneficial outcomes after carotid endarterectomy (CE) are limited to mortality and morbidity rates, costs, and length of hospital stay (LOS). Few have examined the dependency of patien...

    Authors: Fernando José Abelha, Susana Quevedo and Henrique Barros

    Citation: BMC Cardiovascular Disorders 2008 8:33

    Content type: Research article

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  11. Ruptured abdominal aortic aneurysm (AAA) is responsible for 1–2% of all male deaths over the age of 65 years. Early detection of AAA and elective surgery can reduce the mortality risk associated with AAA. Howe...

    Authors: Lars Ehlers, Jan Sørensen, Lotte Groth Jensen, Merete Bech and Mette Kjølby

    Citation: BMC Cardiovascular Disorders 2008 8:32

    Content type: Research article

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  12. Cardiac pacing is a recognized and widely used treatment for patients presenting with bradycardia. Physicians expect patients to return to normal activities almost immediately post implantation. However, patie...

    Authors: Masooma Aqeel, Azam Shafquat and Nawal Salahuddin

    Citation: BMC Cardiovascular Disorders 2008 8:31

    Content type: Research article

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  13. The reduction of blood pressure alone does not eliminate the increased risk of arterial hypertension. Whilst concomitant metabolic risk factors have been shown to be responsible, the available pharmacotherapy ...

    Authors: Peter Bramlage, Eleonore Schönrock and Peter Odoj

    Citation: BMC Cardiovascular Disorders 2008 8:30

    Content type: Research article

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  14. The Paracetamol (Acetaminophen) In Stroke (PAIS) study is a phase III multicenter, double blind, randomized, placebo-controlled clinical trial of high-dose acetaminophen in patients with acute stroke. The tria...

    Authors: Heleen M den Hertog, H Bart van der Worp, H Maarten A van Gemert, Ale Algra, L Jaap Kappelle, Jan van Gijn, Peter J Koudstaal and Diederik WJ Dippel

    Citation: BMC Cardiovascular Disorders 2008 8:29

    Content type: Erratum

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    The original article was published in BMC Cardiovascular Disorders 2005 5:24

  15. The objective was to explore the relationship between left ventricular ejection fraction (LVEF) assessed during hospitalization for acute myocardial infarction (MI) and later health-related quality of life (HR...

    Authors: Kjell I Pettersen, Elena Kvan, Arnfinn Rollag, Knut Stavem and Aasmund Reikvam

    Citation: BMC Cardiovascular Disorders 2008 8:28

    Content type: Research article

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  16. To establish an efficient prophylaxis of coronary artery disease reliable risk stratification is crucial, especially in the high risk population of patients suffering from diabetes mellitus. This prospective s...

    Authors: Alexander Becker, Alexander W Leber, Christoph Becker, Franz von Ziegler, Janine Tittus, Ines Schroeder, Gerhard Steinbeck and Andreas Knez

    Citation: BMC Cardiovascular Disorders 2008 8:27

    Content type: Research article

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  17. The ankle brachial index (ABI) is a well-established tool for screening and diagnosis of peripheral arterial disease (PAD). In this study we assessed the validity of ABI determination using a pocket Doppler de...

    Authors: Saskia PA Nicolaï, Lotte M Kruidenier, Ellen V Rouwet, Liliane Wetzels-Gulpers, Constantijn AM Rozeman, Martin H Prins and Joep AW Teijink

    Citation: BMC Cardiovascular Disorders 2008 8:26

    Content type: Research article

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  18. Although morbidity and mortality from coronary heart disease (CHD) are high, only a minority of acute coronary syndrome (ACS) survivors accesses an effective secondary prevention program. We aim to determine w...

    Authors: Lis Neubeck, Julie Redfern, Tom Briffa, Adrian Bauman, David Hare and SB Freedman

    Citation: BMC Cardiovascular Disorders 2008 8:25

    Content type: Study protocol

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  19. Experimental and epidemiological evidence suggests that homocysteine (tHcy) may be a causal risk factor for atherosclerosis. B-vitamin supplements reduce tHcy and improve endothelial function in short term tri...

    Authors: Kathleen Potter, Graeme J Hankey, Daniel J Green, John Eikelboom, Konrad Jamrozik and Leonard F Arnolda

    Citation: BMC Cardiovascular Disorders 2008 8:24

    Content type: Research article

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  20. The adverse effects of tobacco abuse on cardiovascular outcomes are well-known. However, the impact of passive smoke exposure on angina status and therapeutic response is less well-established. We examined the...

    Authors: Stilianos Efstratiadis, Elizabeth D Kennard, Sheryl F Kelsey and Andrew D Michaels

    Citation: BMC Cardiovascular Disorders 2008 8:23

    Content type: Research article

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  21. Many patients suffering acute myocardial infarction (AMI) are transferred from one hospital to another during their hospitalization. There is little information about the outcomes related to interhospital tran...

    Authors: John M Westfall, Catarina I Kiefe, Norman W Weissman, Anthony Goudie, Robert M Centor, O Dale Williams and Jeroan J Allison

    Citation: BMC Cardiovascular Disorders 2008 8:22

    Content type: Research article

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  22. Up-regulation of vascular endothelin type B (ETB) receptors is implicated in the pathogenesis of cardiovascular disease. Culture of intact arteries has been shown to induce similar receptor alterations and has th...

    Authors: David Nilsson, Lotta Gustafsson, Angelica Wackenfors, Bodil Gesslein, Lars Edvinsson, Per Paulsson, Richard Ingemansson and Malin Malmsjö

    Citation: BMC Cardiovascular Disorders 2008 8:21

    Content type: Research article

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  23. Recent studies have documented an increased risk of cardiovascular disease (CVD) in persons with systolic blood pressures of 120–139 mmHg and/or diastolic blood pressures of 80–89 mmHg, classified as prehypert...

    Authors: Trevor S Ferguson, Novie OM Younger, Marshall K Tulloch-Reid, Marilyn B Lawrence Wright, Elizabeth M Ward, Deanna E Ashley and Rainford J Wilks

    Citation: BMC Cardiovascular Disorders 2008 8:20

    Content type: Research article

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  24. Ultrasound (US) has been used to enhance thrombolytic therapy in the treatment of stroke. Considerable attenuation of US intensity is however noted if US is applied over the temporal bone. The aim of this stud...

    Authors: Bjarne Madsen Härdig, Jonas Carlson and Anders Roijer

    Citation: BMC Cardiovascular Disorders 2008 8:19

    Content type: Research article

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  25. The ten year probability of cardiovascular events can be calculated, but many people are unaware of their risk and unclear how to reduce it. The aim of this study was to assess whether a community based interv...

    Authors: Gill Richardson, Hugo C van Woerden, Lucy Morgan, Rhiannon Edwards, Monica Harries, Elaine Hancock, Susan Sroczynsk and Mererid Bowley

    Citation: BMC Cardiovascular Disorders 2008 8:18

    Content type: Research article

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  26. The registration of non-fatal and fatal MI events initiated 1985 in the WHO MONICA project has been ongoing in northern Sweden since the end of the WHO project in 1995. The purpose of the present study was to ...

    Authors: Dan Lundblad, Lars Holmgren, Jan-Håkan Jansson, Ulf Näslund and Mats Eliasson

    Citation: BMC Cardiovascular Disorders 2008 8:17

    Content type: Research article

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  27. Heart failure is a major and growing public health problem worldwide. The prognosis of Heart Failure (HF) is uniformly poor despite advances in treatment. The aims of the present study were to determine the ca...

    Authors: Kamilu M Karaye and Mahmoud U Sani

    Citation: BMC Cardiovascular Disorders 2008 8:16

    Content type: Research article

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  28. Several polymorphisms within the renin-angiotensin system cluster of genes have been associated with the advent of coronary artery disease (CAD) or related pathologies. We investigated the distribution of 5 of...

    Authors: Ana I Freitas, Isabel Mendonça, Maria Brión, Miguel M Sequeira, Roberto P Reis, Angel Carracedo and António Brehm

    Citation: BMC Cardiovascular Disorders 2008 8:15

    Content type: Research article

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  29. Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that appl...

    Authors: Sandra Lindstedt, Per Paulsson, Arash Mokhtari, Bodil Gesslein, Joanna Hlebowicz, Malin Malmsjö and Richard Ingemansson

    Citation: BMC Cardiovascular Disorders 2008 8:14

    Content type: Research article

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  30. Non-pharmacological treatment options for hypertension have the potential to reduce the risk of cardiovascular disease at a population level. Animal studies have suggested that garlic reduces blood pressure, b...

    Authors: Karin Ried, Oliver R Frank, Nigel P Stocks, Peter Fakler and Thomas Sullivan

    Citation: BMC Cardiovascular Disorders 2008 8:13

    Content type: Research article

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  31. The metabolic syndrome (Msyn) affects about 40% of those with hypertension. The Msyn and hypertension have a common pathophysiology. Exercise is recommended for their treatment, prevention and control. The inf...

    Authors: Linda S Pescatello, Bruce E Blanchard, Jaci L Van Heest, Carl M Maresh, Heather Gordish-Dressman and Paul D Thompson

    Citation: BMC Cardiovascular Disorders 2008 8:12

    Content type: Research article

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  32. Acute vigorous exercise, associated with increased release of plasma catecholamines, transiently increases the risk of primary cardiac arrest. We tested the effect of acute submaximal exercise on vasoactive su...

    Authors: Konstantinos Petidis, Stella Douma, Michael Doumas, Ilias Basagiannis, Konstantinos Vogiatzis and Chrysanthos Zamboulis

    Citation: BMC Cardiovascular Disorders 2008 8:11

    Content type: Research article

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  33. In Shanghai there are 1.2 million people with hypertension, many of whom have difficulty in affording medical treatment. Community based, anti-hypertensive clubs have been created to provide health education b...

    Authors: Feng Xue, Wen Yao and Robert J Lewin

    Citation: BMC Cardiovascular Disorders 2008 8:10

    Content type: Research article

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  34. Hypoxia inducible factor-1 (HIF-1) is a transcription factor that functions to maintain cellular homeostasis in response to hypoxia. There is evidence that HIF-1 can also trigger apoptosis, possibly when cellu...

    Authors: Ricky Malhotra, David W Tyson, Henry M Rosevear and Frank C Brosius III

    Citation: BMC Cardiovascular Disorders 2008 8:9

    Content type: Research article

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  35. Currently used biomarkers for cardiac ischemia are elevated in blood plasma after a delay of several hours and therefore unable to detect acute coronary syndrome (ACS) in a very early stage. General practition...

    Authors: Madeleine HE Bruins Slot, Geert JMG van der Heijden, Frans H Rutten, Onno P van der Spoel, E Gijs Mast, Ad C Bredero, Pieter A Doevendans, Jan FC Glatz and Arno W Hoes

    Citation: BMC Cardiovascular Disorders 2008 8:8

    Content type: Study protocol

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  36. The aim of this study was to evaluate the combination of a rapid intravenous infusion of cold saline and endovascular hypothermia in a closed chest pig infarct model.

    Authors: Matthias Götberg, Goran K Olivecrona, Henrik Engblom, Martin Ugander, Jesper van der Pals, Einar Heiberg, Håkan Arheden and David Erlinge

    Citation: BMC Cardiovascular Disorders 2008 8:7

    Content type: Research article

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  37. Cardiovascular diseases and their associated risk factors remain the main cause of mortality in western societies. In order to assess the prevalence of cardiovascular risk factors (CVRFs) in the Caucasian popu...

    Authors: Mathieu Firmann, Vladimir Mayor, Pedro Marques Vidal, Murielle Bochud, Alain Pécoud, Daniel Hayoz, Fred Paccaud, Martin Preisig, Kijoung S Song, Xin Yuan, Theodore M Danoff, Heide A Stirnadel, Dawn Waterworth, Vincent Mooser, Gérard Waeber and Peter Vollenweider

    Citation: BMC Cardiovascular Disorders 2008 8:6

    Content type: Research article

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  38. Recessive mutations in WRN gene eliminate WRN protein function (helicase) and cause Werner syndrome. One of the most important clinical features of Werner syndrome patients are the premature onset and accelerated...

    Authors: Elena Castro, Vladimir Oviedo-Rodríguez and Luis I Angel-Chávez

    Citation: BMC Cardiovascular Disorders 2008 8:5

    Content type: Research article

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  39. In the present study we sought to determine the long-term prognostic value of left ventricular ejection fraction (LVEF), assessed by planar radionuclide ventriculography (PRV), after ST-elevation myocardial in...

    Authors: Pieter A van der Vleuten, Saman Rasoul, Willem Huurnink, Iwan CC van der Horst, Riemer HJA Slart, Stoffer Reiffers, Rudi A Dierckx, René A Tio, Jan Paul Ottervanger, Menko-Jan De Boer and Felix Zijlstra

    Citation: BMC Cardiovascular Disorders 2008 8:4

    Content type: Research article

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  42. Hyperhomocysteinemia has been identified as a potential risk for atherosclerotic disease in epidemiologic studies. This study investigates the impact of elevated serum homocysteine on restenosis after carotid ...

    Authors: Renata Hillenbrand, Andreas Hillenbrand, Florian Liewald and Julian Zimmermann

    Citation: BMC Cardiovascular Disorders 2008 8:1

    Content type: Research article

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  43. Continuous positive airway pressure (CPAP) treatment for acute cardiogenic pulmonary edema can have important benefits in acute cardiac care. However, coronary care units are usually not equipped and their per...

    Authors: Willem Dieperink, Tiny Jaarsma, Iwan CC van der Horst, Wybe Nieuwland, Karin M Vermeulen, Hanka Rosman, Leon PHJ Aarts, Felix Zijlstra and Maarten WN Nijsten

    Citation: BMC Cardiovascular Disorders 2007 7:40

    Content type: Research article

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  44. Multi-detector computed tomography angiography (MDCTA) has been increasingly used in the evaluation of the coronary arteries. The purpose of this study was to review the literature on the diagnostic performanc...

    Authors: Piet K Vanhoenacker, Isabel Decramer, Olivier Bladt, Giovanna Sarno, Charlotte Bevernage and William Wijns

    Citation: BMC Cardiovascular Disorders 2007 7:39

    Content type: Research article

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  45. The primary objective of this study is to estimate the association between body mass index (BMI) and the risk of first acute myocardial infarction (AMI). As a secondary objective, we considered the association...

    Authors: Joseph AC Delaney, Stella S Daskalopoulou, James M Brophy, Russell J Steele, Lucie Opatrny and Samy Suissa

    Citation: BMC Cardiovascular Disorders 2007 7:38

    Content type: Research article

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  46. Nesiritide is indicated in the treatment of acute decompensated heart failure. However, a recent meta-analysis reported that nesiritide may be associated with an increased risk of death. Our goal was to evalua...

    Authors: Richard J Carroll, Zuber D Mulla, Loran D Hauck and Audrey Westbrook

    Citation: BMC Cardiovascular Disorders 2007 7:37

    Content type: Research article

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  47. A large number of studies have reported on the psychosocial risk factor pattern prior to coronary heart disease events, but few have investigated the situation during the first year after an event, and none ha...

    Authors: Mats Gulliksson, Gunilla Burell, Lennart Lundin, Henrik Toss and Kurt Svärdsudd

    Citation: BMC Cardiovascular Disorders 2007 7:36

    Content type: Research article

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  48. Studies have suggested that the prevention and treatment of coronary heart disease may not have been as effective in women as in men. Therefore, we aimed to examine whether the incidence, attack rate and morta...

    Authors: Hanna-Riikka Lehto, Seppo Lehto, Aki S Havulinna, Matti Ketonen, Aapo Lehtonen, Y Antero Kesäniemi, Juhani Airaksinen and Veikko Salomaa

    Citation: BMC Cardiovascular Disorders 2007 7:35

    Content type: Research article

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  50. Little is known about the impact of severity of hypertension on the association of genes with high blood pressure, which may cause the inconsistently reported associations of peroxisome proliferator-activated ...

    Authors: Gaoqiang Xie, Dongshuang Guo, Ying Li, Shengying Liang and Yangfeng Wu

    Citation: BMC Cardiovascular Disorders 2007 7:33

    Content type: Research article

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