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Structural Diseases, Heart Failure & Congenital

This section concerns all aspects of structural cardiac diseases, heart failure and congenital disorders, including cardiomyopathies, inherited conditions and septal defects. The section considers articles concerning the prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. The primitive neuroectodermal tumors (PNETs) are a family of highly malignant tumors with a multidirectional differential potential. The tumors are characterized by aggressive small round tumor cells that orig...

    Authors: Jingjing Wang, Jing Li, Xiao Zhang, Xiaobo Zhang and Yueyong Xiao

    Citation: BMC Cardiovascular Disorders 2021 21:305

    Content type: Case report

    Published on:

  2. Despite significant progress in surgical treatment of hypoplastic left heart syndrome (HLHS), its mortality and morbidity are still high. Little is known about the molecular abnormalities of the syndrome. In t...

    Authors: Xuelan Liu, Honglei Shang, Bin Li, Liyun Zhao, Ying Hua, Kaiyuan Wu, Manman Hu and Taibing Fan

    Citation: BMC Cardiovascular Disorders 2021 21:300

    Content type: Research article

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  3. Although systemic lupus erythematosus (SLE) can affect the cardiovascular system in many ways with diverse presentations, a severe cardiogenic shock secondary to SLE myocarditis is infrequently described in th...

    Authors: Jaydeep J. Raval, Christina Rodriguez Ruiz, James Heywood and Jason J. Weiner

    Citation: BMC Cardiovascular Disorders 2021 21:294

    Content type: Case report

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  4. Cancer associated thrombosis is recognized. However, pulmonary embolism (PE) from testicular cancer is rarely reported. Right ventricular (RV) function and PE are closely related. The RV cannot cope with a sud...

    Authors: Khaled Elenizi, Rasha Alharthi and Michel Galinier

    Citation: BMC Cardiovascular Disorders 2021 21:260

    Content type: Case report

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  5. The study analyzes changes in lung function, pulmonary pressure and diffusing capacity of the lung in patients with mitral valve regurgitation (MR) treated by MitraClip implantation.

    Authors: Lucie Kretzler, Stephan Große, Stephan Wiedemann, Carsten Wunderlich, Chris Nowak, Christian Riedel, Tomáš Sieger and Steffen Schoen

    Citation: BMC Cardiovascular Disorders 2021 21:235

    Content type: Research article

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  6. 8–28% of patients infected with COVID-19 have evidence of cardiac injury, and this is associated with an adverse prognosis. The cardiovascular mechanisms of injury are poorly understood and speculative. We aim...

    Authors: Shirjel R. Alam, Anoop S. V. Shah, Kevin O. Ombati, Edward Nganga, Samuel Gitau, Khalid Makhdomi, Michael H. Chung and Sudhir Vinayak

    Citation: BMC Cardiovascular Disorders 2021 21:234

    Content type: Study protocol

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  7. Diabetes mellitus-related cardiomyopathy (DMCMP), defined as left ventricular (LV) dysfunction caused by hyperglycemia in the absence of coronary artery disease, leads to heart failure (HF). Previous studies h...

    Authors: Satoshi Oka, Takahiko Kai, Katsuomi Hoshino, Kazunori Watanabe, Jun Nakamura, Makoto Abe and Akinori Watanabe

    Citation: BMC Cardiovascular Disorders 2021 21:217

    Content type: Research article

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  8. Catecholamine excess arising from pheochromocytomas and paragangliomas (PPGLs) can cause a wide spectrum of cardiac manifestations, including acute cardiac complications (ACCs) and subclinical myocardial injur...

    Authors: Jing Zhou, He Xuan, Yunxiang Miao, Junting Hu and Yunlang Dai

    Citation: BMC Cardiovascular Disorders 2021 21:203

    Content type: Research article

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  9. Impact of recurrent pericarditis (RP) on patient health-related quality of life (HRQoL) was evaluated through qualitative patient interviews and as an exploratory endpoint in a Phase 2 trial evaluating the eff...

    Authors: David Lin, Allan Klein, David Cella, Anna Beutler, Fang Fang, Matt Magestro, Paul Cremer, Martin M. LeWinter, Sushil Allen Luis, Antonio Abbate, Andrew Ertel, Leighann Litcher-Kelly, Brittany Klooster and John F. Paolini

    Citation: BMC Cardiovascular Disorders 2021 21:201

    Content type: Research article

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  10. Coronary artery fistula (CAF) is a rare congenital anomaly with a challenging scenario in children. This study reports our experience in transcatheter closure of CAF with Nit-Occlude PDA coil and midterm clini...

    Authors: Hamid Amoozgar, Mohammad Reza Edraki, Amir Naghshzan, Nima Mehdizadegan, Hamid Mohammadi, Gholamhossein Ajami and Ahmad Ali Amirghofran

    Citation: BMC Cardiovascular Disorders 2021 21:192

    Content type: Research article

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  11. Resuscitation using a percutaneous mechanical circulatory support device (iCPR) improves survival after cardiac arrest (CA). We hypothesized that the addition of inhaled nitric oxide (iNO) during iCPR might pr...

    Authors: Christoph Nix, Rashad Zayat, Andreas Ebeling, Andreas Goetzenich, Uma Chandrasekaran, Rolf Rossaint, Nima Hatam and Matthias Derwall

    Citation: BMC Cardiovascular Disorders 2021 21:189

    Content type: Research article

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  12. Prenatal diagnosis of coarctation of the aorta (CoA) is challenging for most examiners. The malformation often occurs at the aortic isthmus, which is a short segment between the origin of the left subclavian a...

    Authors: Yu Wang, Caixia Liu, Ying Zhang and Meilian Wang

    Citation: BMC Cardiovascular Disorders 2021 21:176

    Content type: Case report

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  13. Autopsies regularly aim to clarify the cause of death; however, relatives may directly benefit from autopsy results in the setting of heritable traits (“mortui vivos docent”).

    Authors: Benno Hartung, Anne Tank, Sven Dittmann, Stefanie Ritz-Timme and Eric Schulze-Bahr

    Citation: BMC Cardiovascular Disorders 2021 21:174

    Content type: Case report

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  14. The primary aim was to observe the predictive value of P-wave ECG index and left atrial appendage volume (LLAV) for atrial fibrillation recurrence after first radiofrequency catheter ablation.

    Authors: Ruibin Li, Xiaohong Yang, Min Jia, Dong Wang, Xiaoran Cui, Long Bai, Lei Zhao and Jidong Zhang

    Citation: BMC Cardiovascular Disorders 2021 21:164

    Content type: Research article

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  15. The study evaluated the cost of baroreflex activation therapy plus guideline directed therapy (BAT + GDT) compared to GDT alone for HF patients with reduced ejection fraction and New York Heart Association Cla...

    Authors: John Bisognano, John E. Schneider, Shawn Davies, Robert L. Ohsfeldt, Elizabeth Galle, Ivana Stojanovic, Thomas F. Deering, JoAnn Lindenfeld and Michael R. Zile

    Citation: BMC Cardiovascular Disorders 2021 21:155

    Content type: Research article

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  16. Appropriate use criteria (AUC) have been developed in response to growth in cardiac imaging utilization and concern regarding associated costs. Cardiac computed tomography angiography (CCTA) has emerged as an ...

    Authors: Michael Hammer, Muhtashim Mian, Levi Elhadad, Mary Li and Idan Roifman

    Citation: BMC Cardiovascular Disorders 2021 21:154

    Content type: Research article

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  17. Cardiac myxomas (CMs) and thrombi are associated with high morbidity and mortality. These two conditions need totally different treatments. However, they are difficult to distinguish using naked eye. In clinic...

    Authors: Wen-lei Qian, Yu Jiang, Xi Liu, Ying-kun Guo, Yuan Li, Xin Tang and Zhi-gang Yang

    Citation: BMC Cardiovascular Disorders 2021 21:152

    Content type: Research article

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  18. Sudden cardiac deaths are twice more frequent in diabetic patients with cardiac autonomic neuropathy. Sudden cardiac death etiologies remain unclear and no recommendations are made to identify factors associat...

    Authors: Louis Schubert, Suzanne Laroche, Agnès Hartemann, Olivier Bourron and Franck Phan

    Citation: BMC Cardiovascular Disorders 2021 21:140

    Content type: Case report

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  19. The research into the recurrence of cough variant asthma (CVA) in congenital heart disease (CHD) are few in number. The purpose of this study is to investigate the effect of CHD on the risk of the recurrence o...

    Authors: B. W. Feng, C. Y. He, X. Q. Liu, Y. S. Chen and S. R. He

    Citation: BMC Cardiovascular Disorders 2021 21:130

    Content type: Research article

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  20. Liver and renal function evaluated by the model for end-stage liver disease (MELD) score, the MELD excluding the international normalized ratio (MELD_XI) score and the MELD including sodium (MELD_sodium) score...

    Authors: Shengen Liao, Xinyi Lu, Iokfai Cheang, Xu Zhu, Ting Yin, Wenming Yao, Haifeng Zhang and Xinli Li

    Citation: BMC Cardiovascular Disorders 2021 21:128

    Content type: Research article

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  21. Genetic testing in hypertrophic cardiomyopathy (HCM) is a published guideline-based recommendation. The diagnostic yield of genetic testing and corresponding HCM-associated genes have been largely documented b...

    Authors: Julie Hathaway, Krista Heliö, Inka Saarinen, Jonna Tallila, Eija H. Seppälä, Sari Tuupanen, Hannu Turpeinen, Tiia Kangas-Kontio, Jennifer Schleit, Johanna Tommiska, Ville Kytölä, Miko Valori, Mikko Muona, Johanna Sistonen, Massimiliano Gentile, Pertteli Salmenperä…

    Citation: BMC Cardiovascular Disorders 2021 21:126

    Content type: Research article

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  22. Thyroid storm (TS) is a rare but potentially life-threatening sequelae of untreated or undertreated hyperthyroidism. While TS frequently causes high-output heart failure, low-output heart failure related to di...

    Authors: Hiroyuki Yamamoto, Satoshi Monno, Keiko Ohta-Ogo, Hatsue Ishibashi-Ueda and Toru Hashimoto

    Citation: BMC Cardiovascular Disorders 2021 21:124

    Content type: Case report

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  23. Chagas disease is a pathogenic parasitic infection with approximately 8 million cases worldwide and greater than 300,000 cases in the United States (U.S.). Chagas disease can lead to chronic cardiomyopathy and...

    Authors: Sanchi Malhotra, Imran Masood, Noberto Giglio, Jay D. Pruetz and Pia S. Pannaraj

    Citation: BMC Cardiovascular Disorders 2021 21:116

    Content type: Research article

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  24. Obtaining vascular access can be challenging during resuscitation following cardiac arrest, and it is particularly difficult and time-consuming in paediatric patients. We aimed to compare the efficacy of high-...

    Authors: Daesung Lim, Soo Hoon Lee, Dong Hoon Kim, Changwoo Kang, Jin Hee Jeong and Sang Bong Lee

    Citation: BMC Cardiovascular Disorders 2021 21:113

    Content type: Research article

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  25. The natural history of patients with moderate aortic stenosis (AS) is poorly understood. We aimed to determine the long-term outcomes of patients with moderate AS.

    Authors: Yu Du, Mario Gössl, Santiago Garcia, Maurice Enriquez-Sarano, Joao L. Cavalcante, Richard Bae, Go Hashimoto, Miho Fukui, Bernardo Lopes, Aisha Ahmed, Christian Schmidt, Larissa Stanberry, Ross Garberich, Steven M. Bradley, Robert Steffen and Paul Sorajja

    Citation: BMC Cardiovascular Disorders 2021 21:108

    Content type: Research article

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  26. Conventional risk factors for sudden cardiac death (SCD) justify primary prevention through implantable cardioverter-defibrillator (ICD) implantation in hypertrophic cardiomyopathy (HCM) patients. However, the...

    Authors: Kyoichiro Yazaki, Atsushi Suzuki, Tsuyoshi Shiga, Yuichiro Minami, Kotaro Arai, Kyomi Ashihara, Morio Shoda and Nobuhisa Hagiwara

    Citation: BMC Cardiovascular Disorders 2021 21:106

    Content type: Research article

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  27. Studies have demonstrated that heart failure (HF) patients who receive direct pharmacist input as part of multidisciplinary care have better clinical outcomes. This study evaluated/compared the difference in p...

    Authors: Daya Ram Parajuli, Sepehr Shakib, Joanne Eng-Frost, Ross A. McKinnon, Gillian E. Caughey and Dean Whitehead

    Citation: BMC Cardiovascular Disorders 2021 21:104

    Content type: Research article

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  28. Inflammation is involved in the progression of degenerative valvular heart disease (DVHD). microRNA-222 (miR-222) contributes to inflammation-mediated vascular remodeling, but its involvement in DVHD in relati...

    Authors: Hualan Zhou, Sen Lin, Xia Li, Dianxuan Guo, Yun Wang and Youdong Hu

    Citation: BMC Cardiovascular Disorders 2021 21:98

    Content type: Research article

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  29. Sevoflurane postconditioning (SevP) effectively relieves myocardial ischemia/reperfusion (I/R) injury but performs poorly in the diabetic myocardium. Previous studies have revealed the important role of increa...

    Authors: Jing Yu, Jiandong He, Wenqu Yang, Xiang Wang, Gaoxiang Shi, Yinglei Duan, Hui Wang and Chongfang Han

    Citation: BMC Cardiovascular Disorders 2021 21:96

    Content type: Research article

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  30. Necrotizing autoimmune myopathy (NAM) is pathologically characterized by myofiber necrosis and regeneration with paucity or absence of inflammatory cells in muscle biopsy. Two autoantibodies, namely anti-signa...

    Authors: Xue Ma, Li Xu, Yue Li and Bitao Bu

    Citation: BMC Cardiovascular Disorders 2021 21:88

    Content type: Case report

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  31. Myocardial iron overload in patients with thalassemia major (TM) is one of the most important complications. The purpose of the study was to identify advanced echocardiography parameters for early identificati...

    Authors: Michael J. Bonios, Epameinontas Fountas, Polyxeni Delaporta, Stamatis Kyrzopoulos, Antonis Kattamis, Stamatis N. Adamopoulos and Dimitris Tsiapras

    Citation: BMC Cardiovascular Disorders 2021 21:81

    Content type: Research article

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  32. This study aimed to determine the left ventricular (LV) systolic function in patients on maintenance hemodialysis (MHD) using the myocardial work (MW) technique and investigate the clinical value of the MW tec...

    Authors: Chang Liu, Yi-Ping Feng, Zi-Ning Yan, Li Fan, Yi-Fei Rui and Ling Cui

    Citation: BMC Cardiovascular Disorders 2021 21:76

    Content type: Research article

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  33. The minimal clinically important difference (MCID) of a patient-reported outcome (PRO) represents the threshold value of the change in the score for that PRO. It is deemed to have an important implication in c...

    Authors: Jing Tian, Jinghua Zhao, Qing Zhang, Jia Ren, Linai Han, Jing Li, Yanbo Zhang and Qinghua Han

    Citation: BMC Cardiovascular Disorders 2021 21:58

    Content type: Research article

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  34. The absence of a pulmonary artery is a rare congenital anomaly that occurs isolated or with other congenital cardiac disorders, particularly tetralogy of Fallot (TOF); meanwhile, a hidden pulmonary artery migh...

    Authors: Mohammadreza Edraki, Bahram Ghasemzadeh, Kambiz Keshavarz, Ahmadali Amirghofran, Hamid Mohammadi, Zahra Kheirandish, Hamid Amoozgar, Elahe Nirooei, Gholamhossein Ajami, Nima Mehdizadegan, Amir Naghshzan, Farah Peiravian, Sirous Cheriki and Mohammad Javad Nobahkti

    Citation: BMC Cardiovascular Disorders 2021 21:56

    Content type: Research article

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  35. Berry syndrome, a rare combination of cardiac anomalies, consists of aortopulmonary window (APW); aortic origin of the right pulmonary artery; interrupted aortic arch (IAA) or hypoplastic aortic arch or coarct...

    Authors: Wen-jing Bi, Yang-jie Xiao, Yue-jia Liu, Yang Hou and Wei-dong Ren

    Citation: BMC Cardiovascular Disorders 2021 21:15

    Content type: Case report

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  36. The incompetent bicuspid aortic valve (BAV) can be replaced or repaired using various surgical techniques. This study sought to assess the efficacy of external annuloplasty and postoperative reverse remodellin...

    Authors: Marek J. Jasinski, Karol Miszalski-Jamka, Kinga Kosiorowska, Radoslaw Gocol, Izabella Wenzel-Jasinska, Grzegorz Bielicki, Mikolaj Berezowski, Marceli Lukaszewski, Andrzej Kansy and Marek A. Deja

    Citation: BMC Cardiovascular Disorders 2021 21:13

    Content type: Research article

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    The Correction to this article has been published in BMC Cardiovascular Disorders 2021 21:89

  37. Although most cases of atrial septal defect (ASD) are sporadic, familial cases have been reported, which may be caused by mutation of transcription factor GATA binding protein 4 (GATA4). Herein we combined whole-...

    Authors: Haisong Bu, Guowen Sun, Yun Zhu, Yifeng Yang, Zhiping Tan, Tianli Zhao and Shijun Hu

    Citation: BMC Cardiovascular Disorders 2021 21:12

    Content type: Research article

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  38. We aimed to use the Medical Information Mart for Intensive Care III database to build a nomogram to identify 30-day mortality risk of deep vein thrombosis (DVT) patients in intensive care unit (ICU).

    Authors: Runnan Shen, Ming Gao, Yangu Tao, Qinchang Chen, Guitao Wu, Xushun Guo, Zuqi Xia, Guochang You, Zilin Hong and Kai Huang

    Citation: BMC Cardiovascular Disorders 2021 21:11

    Content type: Research article

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  39. Cardiac vasculitis is recognized as a heterogeneous disease process with a wide spectrum of manifestations including pericarditis, myocarditis, valvular heart disease and less frequently, coronary artery vascu...

    Authors: Shaun Khanna, Kartheek Garikapati, Daniel S. L. Goh, Kenneth Cho, Phillip Lo, Mohan V. Bhojaraja and Surjit Tarafdar

    Citation: BMC Cardiovascular Disorders 2021 21:7

    Content type: Review

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  40. Inflammatory cells infiltrate into the ischemic and hypoxic myocardial tissue after myocardial infarction. B cells gather at the site of myocardial injury and secrete cytokines to regulate immune inflammation ...

    Authors: Fanrui Mo, Ying Luo, Yuluan Yan, Juan Li, Shayi Lai and Weifeng Wu

    Citation: BMC Cardiovascular Disorders 2021 21:5

    Content type: Research article

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  41. Calcific aortic valve disease (CAVD) pathophysiology is a complex, multistage process, usually diagnosed at advanced stages after significant anatomical and hemodynamic changes in the valve. Early detection of...

    Authors: Ishita Tandon, Shelby Johns, Alan Woessner, Jessica Perez, Delaney Cross, Asya Ozkizilcik, Timothy J. Muldoon, Srikanth Vallurupalli, Muralidhar Padala, Kyle P. Quinn and Kartik Balachandran

    Citation: BMC Cardiovascular Disorders 2020 20:521

    Content type: Research article

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  42. Eosinophilic myocarditis (EM) is a rare form of myocarditis. Clinical presentation is various, includes cardiogenic shock and can often be fatal. Diagnosis is based on myocardial eosinophilic infiltration in e...

    Authors: Mintje Bohné, Da-Un Chung, Eike Tigges, Hendrick van der Schalk, Daniela Waddell, Niklas Schenker, Stephan Willems, Karin Klingel, Dietmar Kivelitz and Edda Bahlmann

    Citation: BMC Cardiovascular Disorders 2020 20:519

    Content type: Case report

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  43. Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disease that affects approximately one in 500 people. HCM is a recognized genetic disorder most often caused by mutations involving...

    Authors: Lazar Velicki, Djordje G. Jakovljevic, Andrej Preveden, Miodrag Golubovic, Marija Bjelobrk, Aleksandra Ilic, Snezana Stojsic, Fausto Barlocco, Maria Tafelmeier, Nduka Okwose, Milorad Tesic, Paul Brennan, Dejana Popovic, Arsen Ristic, Guy A. MacGowan, Nenad Filipovic…

    Citation: BMC Cardiovascular Disorders 2020 20:516

    Content type: Research article

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  44. Patients with Heart Failure (HF) show impaired functional capacities which have been related to their prognosis. Moreover, physical functional performance in functional tests has also been related to the progn...

    Authors: Iván José Fuentes-Abolafio, Brendon Stubbs, Luis Miguel Pérez-Belmonte, María Rosa Bernal-López, Ricardo Gómez-Huelgas and Antonio Ignacio Cuesta-Vargas

    Citation: BMC Cardiovascular Disorders 2020 20:512

    Content type: Research article

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  45. Data on clinical characteristics of acute decompensated heart failure (ADHF) in Malaysia especially in East Malaysia is lacking.

    Authors: Hwei Sung Ling, Bui Khiong Chung, Pin Fen Chua, Kai Xin Gan, Wai Leng Ho, Elora Yoke Ling Ong, Cindy Hui San Kueh, Yie Ping Chin and Alan Yean Yip Fong

    Citation: BMC Cardiovascular Disorders 2020 20:511

    Content type: Research article

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  46. The aim of present study was to examine the preoperative prevalence and distribution of impaired left ventricular global longitudinal strain (LVGLS) in elderly patients with symptomatic aortic stenosis (AS) un...

    Authors: Jonas Agerlund Povlsen, Vibeke Guldbrand Rasmussen, Henrik Vase, Kaare Troels Jensen, Christian Juhl Terkelsen, Evald Høj Christiansen, Mariann Tang, Anders Lehmann Dahl Pedersen and Steen Hvitfeldt Poulsen

    Citation: BMC Cardiovascular Disorders 2020 20:506

    Content type: Research article

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  1. Aortic stiffness is an independent predictor of cardiovascular (CV) events and mortality. However, no data exists for the prognosis of combined aortic stiffness and myocardial ischemia. Using cardiac magnetic ...

    Authors: Yodying Kaolawanich and Thananya Boonyasirinant

    Citation: BMC Cardiovascular Disorders 2020 20:287

    Content type: Research article

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  2. Management of warfarin-associated major haemorrhage in prosthetic valve diseases is difficult as there is a fine line between haemorrhage and thrombosis. An individual’s propensity towards thrombosis, such as ...

    Authors: Mustafa Oguz, Ahmet Ayaz and Mehmet Emin Adin

    Citation: BMC Cardiovascular Disorders 2020 20:286

    Content type: Case report

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  3. Underweight or obese status influences the prognosis of atrial fibrillation (AF). However, the association between stratification of body mass index (BMI) and in-hospital outcomes in patients with AF, remains ...

    Authors: Fuxue Deng, Yan Zhang, Qiang Zhao, Yangyang Deng, Shanshan Gao, Lisha Zhang, Mengya Dong, Zuyi Yuan and Xinjun Lei

    Citation: BMC Cardiovascular Disorders 2020 20:270

    Content type: Research article

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  4. Peripartum cardiomyopathy (PPCM) is life-threatening heart disease. However, the causes and pathogenesis of PPCM remain unclear. Previous studies found that β1 adrenoceptor antibodies (β1AA) had possible invol...

    Authors: Linying Shi, Jia Liu, Yuan Zhang, Mulei Chen and Jiamei Liu

    Citation: BMC Cardiovascular Disorders 2020 20:269

    Content type: Research article

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  5. Cardiovascular disease is second only to cancer recurrence as a determinant of lifespan in cancer survivors, and cancer therapy-related cardiac dysfunction is a clinically important risk factor. We aim to inve...

    Authors: Yoo Jin Hong, Gun Min Kim, Kyunghwa Han, Pan Ki Kim, Su An Lee, Eunkyung An, Ji Yeon Lee, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Min Jung Kim and Byoung Wook Choi

    Citation: BMC Cardiovascular Disorders 2020 20:264

    Content type: Study protocol

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  6. The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied. We aimed to assess whether concurrent aspirin an...

    Authors: Ahmad Said, Scott Keeney, Marsel Matka, Adam Hafeez, Julie George and Alexandra Halalau

    Citation: BMC Cardiovascular Disorders 2020 20:263

    Content type: Research article

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  7. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a potential biomarker for monitoring the status of heart failure. However, the optimal monitoring interval of NT-proBNP is unknown. This study sought to...

    Authors: Zhehao Dai, Taku Asano, Osamu Takahashi, Nobuyuki Komiyama and Sachiko Ohde

    Citation: BMC Cardiovascular Disorders 2020 20:262

    Content type: Research article

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  8. One out of seven patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) may be affected by transthyretin cardiac amyloidosis (ATTR-CA), mostly presenting with low-fl...

    Authors: Guglielmo Gallone, Federico Landra, Fabrizio D’Ascenzo, Federico Conrotto, Roberta Casoni, Francesco Bruno, Pierluigi Omedè, Gianluca Alunni, Alessandro Andreis, Alessandro Vairo, Mauro Giorgi, Antonella Fava and Gaetano Maria De Ferrari

    Citation: BMC Cardiovascular Disorders 2020 20:261

    Content type: Case report

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  9. Heart failure is one of leading cause of death worldwide. However, the transcriptional profiling of heart failure is unclear. Moreover, the signaling pathways and transcription factors involving the heart fail...

    Authors: Haiwei Wang, Xinrui Wang, Liangpu Xu and Hua Cao

    Citation: BMC Cardiovascular Disorders 2020 20:250

    Content type: Research article

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  10. Mean platelet volume (MPV) has been identified as an individual risk factor for stroke and thrombosis. Concurrently, ischaemic stroke caused by nonvalvular atrial fibrillation (AF) has attracted increasing att...

    Authors: Meifang Zheng, Shean Chen, Ye Zhu and Xiang Gu

    Citation: BMC Cardiovascular Disorders 2020 20:241

    Content type: Research article

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  11. May-Thurner syndrome (MTS) or Cockett’s syndrome is a rare clinical syndrome, which refers to the compression of the left common iliac vein (LCIV) by right common iliac artery and vertebral body. Complications...

    Authors: Yan Meng, Hao Qin, Qiang Ma, Junbo Zhang, Bo Zhang, Honggang Pang, Qian Yin and Hongyan Tian

    Citation: BMC Cardiovascular Disorders 2020 20:233

    Content type: Case report

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  12. Children with congenital heart disease (CHD) have an elevated risk of future cardiovascular disease but the underlying mechanisms are unclear. Abdominal obesity (measured as waist circumference) is a risk fact...

    Authors: Erin Barbour-Tuck, Natasha G. Boyes, Corey R. Tomczak, Dana S. Lahti, Chantelle L. Baril, Charissa Pockett, Shonah Runalls, Ashok Kakadekar, Scott Pharis, Timothy J. Bradley, Kristi D. Wright and Marta C. Erlandson

    Citation: BMC Cardiovascular Disorders 2020 20:231

    Content type: Research article

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  13. To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to an...

    Authors: Tian-Yuan Xiong, Chang Liu, Yan-Biao Liao, Wen Zheng, Yi-Jian Li, Xi Li, Yuanweixiang Ou, Zi-Jie Wang, Xi Wang, Chang-Ming Li, Zhen-Gang Zhao, Yuan Feng, Xiao-Jing Liu and Mao Chen

    Citation: BMC Cardiovascular Disorders 2020 20:229

    Content type: Research article

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  14. Inflammation and skeletal muscle wasting often coexist in elderly populations, but few studies have examined their relationship in elderly heart failure (HF) patients. This study examined the relationship betw...

    Authors: Masayuki Koshikawa, Masahide Harada, Shunsuke Noyama, Ken Kiyono, Yuji Motoike, Yoshihiro Nomura, Asuka Nishimura, Hideo Izawa, Eiichi Watanabe and Yukio Ozaki

    Citation: BMC Cardiovascular Disorders 2020 20:228

    Content type: Research article

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  15. Although hospital readmission for heart failure (HF) is an issue for both men and women, little is known about differences in readmission rates by sex. Consequently, strategies to optimize readmission reductio...

    Authors: Amy Hoang-Kim, Camilla Parpia, Cassandra Freitas, Peter C. Austin, Heather J. Ross, Harindra C. Wijeysundera, Karen Tu, Susanna Mak, Michael E. Farkouh, Louise Y. Sun, Michael J. Schull, Robin Mason, Douglas S. Lee and Paula A. Rochon

    Citation: BMC Cardiovascular Disorders 2020 20:223

    Content type: Research article

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  16. Atrial fibrillation (AF), one of the most common comorbidities of heart failure (HF), is associated with worse long-term prognosis in HF patients receiving cardiac resynchronization therapy (CRT). However, the...

    Authors: Minsi Cai, Wei Hua, Nixiao Zhang, Shengwen Yang, Yiran Hu, Min Gu, Hongxia Niu and Shu Zhang

    Citation: BMC Cardiovascular Disorders 2020 20:221

    Content type: Research article

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  17. Atrioesophageal fistula (AEF) is the most fatal complication associated with catheter ablation for atrial fibrillation and cannot be easily detected when thoracic contrast-enhanced computed tomography (CT) is ...

    Authors: Bing Rong, Xiquan Zhang, Hui Tian, Hongyu Zhang, Ning Zhong and Jingquan Zhong

    Citation: BMC Cardiovascular Disorders 2020 20:219

    Content type: Case report

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  18. Epicardial adipose tissue (EAT) remodeling and adipocytokines are associated with structural remodeling in atrial fibrillation (AF). However, the role of omentin-1, a novel adipocytokine, in structural remodel...

    Authors: Yubin Chen, Fen Liu, Fei Han, Lizhi Lv, Can-e Tang, Zhongshang Xie and Fanyan Luo

    Citation: BMC Cardiovascular Disorders 2020 20:214

    Content type: Research article

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  19. Right free wall accessory pathways (AP) are difficult to treat with catheter ablation as ablation catheter (AC) instability at the tricuspid annulus often precludes successful procedure.

    Authors: Matevž Jan, Tine Prolič Kalinšek, Jernej Štublar, Matija Jelenc, Andrej Pernat, David Žižek and Nikola Lakič

    Citation: BMC Cardiovascular Disorders 2020 20:210

    Content type: Research article

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  20. In recent years, the field of cardio-oncology has grown worldwide, bringing benefits to cancer patients in terms of survival and quality of life. This study reports the experience of a pioneer cardio-oncology ...

    Authors: Isabela B. S. da S. Costa, Cristina S. Bittar, Silvia M. R. Fonseca, Carolina M. P. D. e Silva, Marilia H. H. dos Santos Rehder, Stéphanie I. Rizk, Cecilia B. B. V. Cruz, Clara S. Figueiredo, Fernanda T. de A. Andrade, Ludmila de A. Barberino, Fernanda A. de S. Costa, Letticya P. Machado, Thalita B. González, Marcel P. C. Almeida, Julia T. Fukushima, Roberto Kalil Filho…

    Citation: BMC Cardiovascular Disorders 2020 20:206

    Content type: Research article

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  21. Non-ischemic cardiomyopathy (NICM) has been associated with a better left ventricle reverse remodeling response and improved clinical outcomes after cardiac resynchronization therapy (CRT). The aims of our stu...

    Authors: Shengwen Yang, Zhimin Liu, Yiran Hu, Ran Jing, Min Gu, Hongxia Niu, Ligang Ding, Anlu Xing, Shu Zhang and Wei Hua

    Citation: BMC Cardiovascular Disorders 2020 20:205

    Content type: Research article

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  22. Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liv...

    Authors: Jae-Hyung Roh, Jae-Hyeong Park, Hanbyul Lee, Yong-Hoon Yoon, Minsu Kim, Yong-Giun Kim, Gyung-Min Park, Jae-Hwan Lee and In-Whan Seong

    Citation: BMC Cardiovascular Disorders 2020 20:204

    Content type: Research article

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  23. Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intoler...

    Authors: Jasmina Medic Spahic, Fabrizio Ricci, Nay Aung, Erik Hallengren, Jonas Axelsson, Viktor Hamrefors, Olle Melander, Richard Sutton and Artur Fedorowski

    Citation: BMC Cardiovascular Disorders 2020 20:190

    Content type: Research article

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  24. Gestational diabetes mellitus (GDM) is the most common metabolic disorder that can occur during pregnancy and is associated with a long-term risk of both maternal and neonatal comorbidities. This study aimed t...

    Authors: Jing Liu, Guang Song, Tao Meng and Ge Zhao

    Citation: BMC Cardiovascular Disorders 2020 20:184

    Content type: Research article

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  25. Heart failure is associated with ventricular dyssynchrony and energetic inefficiency, which can be alleviated by cardiac resynchronization therapy (CRT) with approximately one-third of non-response rate. Thus ...

    Authors: Xue Gong, Zhonghan Sun, Zheyong Huang, Qian Zhou, Ziqing Yu, Xueying Chen, Wenqi Shao, Yan Zheng, Yixiu Liang, Shengmei Qin, Yangang Su and Junbo Ge

    Citation: BMC Cardiovascular Disorders 2020 20:178

    Content type: Research article

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  26. Human epididymis protein 4 (HE4) was proved to be a novel biomarker for left heart failure. The purpose of this exploratory study was to evaluate the role of HE4 in patients with idiopathic pulmonary arterial ...

    Authors: Qi Jin, Yi Tang, Zhihong Liu, Wenlin Xie, Qin Luo, Zhihui Zhao, Qing Zhao, Zhiwei Huang, Xue Yu, Lu Yan, Changming Xiong, Xinhai Ni and Yinkun Yan

    Citation: BMC Cardiovascular Disorders 2020 20:175

    Content type: Research article

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  27. Insertable cardiac monitors are utilized for the diagnosis of arrhythmias and traditionally have been inserted within hospitals. Recent code updates allow for reimbursement of office-based insertions; however,...

    Authors: Khaled Awad, Raul Weiss, Asim Yunus, Jon M. Bittrick, Rajasekhar Nekkanti, Mahmoud Houmsse, Toshimasa Okabe, Teagan Adamson, Crystal Miller and Abdul K. Alawwa

    Citation: BMC Cardiovascular Disorders 2020 20:171

    Content type: Research article

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  28. Catheter ablation (CA) has emerged as an effective treatment for symptomatic atrial fibrillation (AF). However practice patterns and patient factors associated with referral for CA within the first 12 months a...

    Authors: Robert N. D’Angelo, Rahul Khanna, Robert W. Yeh, Laura Goldstein, Iftekhar Kalsekar, Stephen Marcello, Patricia Tung and Peter J. Zimetbaum

    Citation: BMC Cardiovascular Disorders 2020 20:161

    Content type: Research article

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  29. We studied the course of plasma concentrations of 4 cardiovascular biomarkers: natriuretic peptides (BNP, NT-proBNP; mid-regional (MR) pro-atrial NP); and soluble endothelial CD146 (sCD146), in patients with s...

    Authors: Marc Badoz, Mattia Arrigo, Anne-Claire Mogenet, Malha Sadoune, Nicolas Meneveau, Alexandre Mebazaa and Marie-France Seronde

    Citation: BMC Cardiovascular Disorders 2020 20:157

    Content type: Research article

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  30. Danon disease (OMIM 300257) is an X-linked lysosomal storage disorder, characterized by hypertrophic cardiomyopathy (HCM), skeletal myopathy, variable intellectual disability, and other minor clinical features.

    Authors: Valeria Novelli, Antonio Bisignani, Gemma Pelargonio, Guido Primiano, Maria Lucia Narducci, Vincenzo Palmieri, Francesco Danilo Tiziano, Paolo Zeppilli, Serenella Servidei, Filippo Crea and Maurizio Genuardi

    Citation: BMC Cardiovascular Disorders 2020 20:156

    Content type: Case report

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  31. This study aimed to determine whether a focused 2-day cardiac ultrasound training course could enable physicians to obtain and interpret focused cardiac ultrasound (FCU) images from critically ill patients.

    Authors: Hongmin Zhang, Wei He, Hui Lian, Xiukai Chen, Xiaoting Wang, Yangong Chao and Dawei Liu

    Citation: BMC Cardiovascular Disorders 2020 20:151

    Content type: Research article

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  32. The incidence of CHD is the highest among birth defects and is increasing year to year. CHD seriously harms the health of infants and young children and presents a large economic burden to families and society...

    Authors: Lin Na, Bai Q, Zhao Xiumei, Zhuang Lingzi, He Deqin, Zhuang Xuanxuan, Guo Huanhuan, Lin Yuan and Chen Xiujuan

    Citation: BMC Cardiovascular Disorders 2020 20:139

    Content type: Research article

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  33. Hypoplastic left heart syndrome (HLHS) is a rare but devastating congenital heart defect (CHD) accounting for 25% of all infant deaths due to a CHD. The etiology of HLHS remains elusive, but there is increasin...

    Authors: Andrew Cheng, Whitney Neufeld-Kaiser, Peter H. Byers and Yajuan J. Liu

    Citation: BMC Cardiovascular Disorders 2020 20:137

    Content type: Case report

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  34. The subcutaneous implantable cardioverter defibrillator (S-ICD) is an alternative to the transvenous implantable cardioverter defibrillator for the prevention of sudden cardiac death. Here, we report a rare ca...

    Authors: Yasuhisa Nakao, Kazuyoshi Suenari, Kohei Yamashiro, Hiroshi Nakagawa and Nobuo Shiode

    Citation: BMC Cardiovascular Disorders 2020 20:134

    Content type: Case report

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  35. Left ventricular reverse remodeling (LVRR) has been detected in non-ischemic dilated cardiomyopathy (NIDCM) patients following optimal treatment. However, its prediction with only conventional modalities is of...

    Authors: Togo Iwahana, Sho Okada, Masato Kanda, Motohiko Oshima, Atsushi Iwama, Goro Matsumiya and Yoshio Kobayashi

    Citation: BMC Cardiovascular Disorders 2020 20:116

    Content type: Research article

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  36. Patients with coronary chronic total occlusion (CTO) require effective antiplatelet therapy after percutaneous coronary intervention (PCI). Ticagrelor has more pronounced platelet inhibition than clopidogrel. ...

    Authors: Yong Wang, Hong-wei Zhao, Cheng-fu Wang, Xiao-jiao Zhang, Jie Tao, Chun-sheng Cui, Qing-kun Meng, Yu Zhu, De-feng Luo, Ai-jie Hou and Bo Luan

    Citation: BMC Cardiovascular Disorders 2020 20:109

    Content type: Research article

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  37. In a real-world setting, the effect of pulse rate measured at the time of diagnosis and serially during follow-up and management, on outcomes in heart failure with reduced ejection fraction (HFrEF), has not be...

    Authors: Katherine E. Kurgansky, Petra Schubert, Rachel Parker, Luc Djousse, Jerome B. Riebman, David R. Gagnon and Jacob Joseph

    Citation: BMC Cardiovascular Disorders 2020 20:92

    Content type: Research article

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  38. Gigantic left atrium is defined in the current literature as an excessive dilatation of the left atrium above 65mm. Chronic mitral valve disease is associated with the development of thrombus in the left atriu...

    Authors: Lucia Masarova, Jan Novak, Martin Pesl, Jiri Ondrasek, Jiri Semenka, Eva Simarova and Roman Panovsky

    Citation: BMC Cardiovascular Disorders 2020 20:86

    Content type: Case report

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  39. Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly which has potential for spontaneous rupture into other cardiac chambers or the pericardial space (depending on its location). A ruptured SVA has a ver...

    Authors: Ata Doost, Julie-Ann Craig and Siang Yong Soh

    Citation: BMC Cardiovascular Disorders 2020 20:84

    Content type: Case report

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  40. Tanshinone IIA (TS IIA), a multi-pharmaceutical compound from traditional Chinese herb, is effective for treatment of atherothrombosis. However, the underlying mechanisms of TS IIA-mediated anti-platelet activ...

    Authors: Hua Wang, Lin Zhong, Shaohua Mi, Nianpeng Song, Wei Zhang and Ming Zhong

    Citation: BMC Cardiovascular Disorders 2020 20:81

    Content type: Research article

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  41. Contrast-induced encephalopathy (CIE) is a rare complication of cardiac catheterization; clinical manifestations include cortical blindness, seizures and focal neurological deficits. In general, recurrent epil...

    Authors: Pingping Lei, Weiping He, Quan Shi, Meiying Sun and Zhigang Sun

    Citation: BMC Cardiovascular Disorders 2020 20:79

    Content type: Case report

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  42. Percutaneous closure (LAAC) of the left atrial appendage (LAA) is an efficacious preventive procedure for patients with non-valvular atrial fibrillation (NVAF) and considerable bleeding risk. We sought to syst...

    Authors: Muhammad Ali, Angelos G. Rigopoulos, Mammad Mammadov, Abdelrahman Torky, Andrea Auer, Marios Matiakis, Elena Abate, Constantinos Bakogiannis, Stergios Tzikas, Boris Bigalke, Daniel Sedding and Michel Noutsias

    Citation: BMC Cardiovascular Disorders 2020 20:78

    Content type: Review

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  43. Arrhythmogenic cardiomyopathy (AC) is one of the leading causes for sudden cardiac death (SCD). Recent studies have identified mutations in cardiac desmosomes as key players in the pathogenesis of AC. However,...

    Authors: Xiaoping Lin, Yuankun Ma, Zhejun Cai, Qiyuan Wang, Lihua Wang, Zhaoxia Huo, Dan Hu, Jian’an Wang and Meixiang Xiang

    Citation: BMC Cardiovascular Disorders 2020 20:74

    Content type: Research article

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  44. Cardiac tamponade is a rare but serious complication of Takotsubo cardiomyopathy (TC). Two cases of cardiac tamponade subsequent to TC have been reported. The pericardial effusion in these cases was hemorrhagi...

    Authors: Yuta Nagamori, Takuto Hamaoka, Hisayoshi Murai, Shinichiro Takashima, Takeshi Kato, Soichiro Usui, Kenji Sakata, Hiroshi Furusho, Masaaki Kawashiri and Masayuki Takamura

    Citation: BMC Cardiovascular Disorders 2020 20:67

    Content type: Case report

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  45. Autophagy plays a crucial role in the pathological process of cardiovascular diseases. However, little is known about the pathological mechanism underlying autophagy regulation in dilated cardiomyopathy (DCM).

    Authors: Bo Jin, Haiming Shi, Jun Zhu, Bangwei Wu and Quzhen Geshang

    Citation: BMC Cardiovascular Disorders 2020 20:56

    Content type: Research article

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