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Non-coronary artery cardiac disease

Section edited by Michel Noutsias

This section concerns all aspects of non-coronary artery cardiac disease including but not limited to: arrhythmias, congenital cardiac disease and cardiomyopathies. The section considers articles concerning the prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. The optimal duration of oral anticoagulant therapy for patients with venous thromboembolism (VTE) remains highly uncertain in clinical practice. It is essential to accurately assess the effect of anticoagulant...

    Authors: Wei Wang, Yang Su, Chunyan Wu, Yuxi Sun, Neng Dai, Wei Chen, Jie Zhang, Yawei Xu, Ralph G. Brindis, Dachun Xu and Jue Li

    Citation: BMC Cardiovascular Disorders 2020 20:53

    Content type: Research article

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  2. The etiology of Takayasu arteritis (TA) is unknown; however, a possible relationship between streptococcal infection and TA has been proposed. This study aimed to identify the clinical features and cardiac val...

    Authors: Lili Pan, Juan Du, Junming Zhu, Zhiyu Qiao, Yanlong Ren, Xinsheng Huang, Shichao Guo and Na Gao

    Citation: BMC Cardiovascular Disorders 2020 20:52

    Content type: Research article

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  3. Aortic valve regurgitation (AR) results in left ventricle (LV) volume overload (VO) leading to its dilation and hypertrophy (H). We study a rat model of severe AR induced by puncturing one or two leaflets usin...

    Authors: Elisabeth Walsh-Wilkinson, Marie-Claude Drolet, Marie Arsenault and Jacques Couet

    Citation: BMC Cardiovascular Disorders 2020 20:51

    Content type: Research article

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  4. Previous studies demonstrated impaired lipid metabolism and augmented aerobic glycolysis in AF. The authors aimed to investigate whether the use of metformin, an AMPK activator, could reverse this metabolic re...

    Authors: Yaozhong Liu, Fan Bai, Na Liu, Baojian Zhang, Fen Qin, Tao Tu, Biao Li, Jiayi Li, Yingxu Ma, Feifan Ouyang and Qiming Liu

    Citation: BMC Cardiovascular Disorders 2020 20:50

    Content type: Research article

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  5. Three-dimensional electroanatomic mapping systems have demonstrated a significant reduction in radiation exposure during radiofrequency catheter ablation procedures. We aimed to investigate the safety, feasibi...

    Authors: Guangzhi Chen, Yan Wang, Riccardo Proietti, Xunzhang Wang, Feifan Ouyang, Chang Sheng Ma, Rong Hui Yu, Chunxia Zhao, Kezhong Ma, Jie Qiu, Qigong Liu and Dao Wen Wang

    Citation: BMC Cardiovascular Disorders 2020 20:48

    Content type: Research article

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  6. Cardiac surgery for prosthetic valve endocarditis (PVE) is associated with substantial mortality. We aimed to analyze 30-day and 1-year outcome in patients undergoing surgery for PVE and sought to identify pre...

    Authors: Carolyn Weber, Parwis B. Rahmanian, Melanie Nitsche, Asmae Gassa, Kaveh Eghbalzadeh, Stefanie Hamacher, Julia Merkle, Antje-Christin Deppe, Anton Sabashnikov, Elmar W. Kuhn, Oliver J. Liakopoulos and Thorsten Wahlers

    Citation: BMC Cardiovascular Disorders 2020 20:47

    Content type: Research article

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  7. The current diagnostic methods and treatments still fail to lower the incidence of anthracycline-induced cardiotoxicity effectively. In this study, we aimed to (1) analyze the cardiotoxicity-related genes afte...

    Authors: Wang Yadi, Chen Shurui, Zhang Tong, Chen Suxian, Tong Qing and He Dongning

    Citation: BMC Cardiovascular Disorders 2020 20:43

    Content type: Research article

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  8. We evaluated adherence to dosing criteria for patients with atrial fibrillation (AF) taking dabigatran or rivaroxaban and the impact of off-label dosing on thromboembolic and bleeding risk.

    Authors: Alexandros Briasoulis, Yubo Gao, Chakradhari Inampudi, Paulino Alvarez, Rabea Asleh, Elizabeth Chrischilles, Enrique C. Leira and Mary Vaughan-Sarrazin

    Citation: BMC Cardiovascular Disorders 2020 20:42

    Content type: Research article

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  9. Although mineral metabolism disorder influences cardiac valvular calcification (CVC), few previous studies have examined the effects of non-calcium-containing and calcium-containing phosphate binders on CVC in...

    Authors: Kentaro Watanabe, Hideki Fujii, Keiji Kono, Shunsuke Goto and Shinichi Nishi

    Citation: BMC Cardiovascular Disorders 2020 20:39

    Content type: Research article

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  10. Atrial fibrillation with symptomatic bradycardia, higher grade atrioventricular block, and sinus node disease are all common indications for permanent pacemaker implantation. The most frequent causes of sinus ...

    Authors: Jörg Reifart, Marlene Tschernatsch, Christian W. Hamm, Johannes Sperzel and Andreas Hain

    Citation: BMC Cardiovascular Disorders 2020 20:30

    Content type: Case report

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  11. The gut microbiome plays an important role in various cardiovascular diseases, such as atherosclerosis and hypertension, which are associated with abdominal aortic aneurysms (AAAs).

    Authors: Jiahe Xie, Weiling Lu, Lintao Zhong, Yuhua Hu, Qingrui Li, Rongming Ding, Zhonggao Zhong, Ziyou Liu, Hai Xiao, Dongming Xie, Guofu Zheng, Bo Ye, Yiming Zhong and Zuheng Liu

    Citation: BMC Cardiovascular Disorders 2020 20:32

    Content type: Research article

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  12. Evidence-based recommendations about anticoagulation in acute type B aortic dissection (TBAD) are completely missing, but there is a diffuse conviction that it could prevent the healing process of the dissecte...

    Authors: Pier Paolo Bocchino, Ovidio De Filippo, Francesco Piroli, Paolo Scacciatella, Massimo Imazio, Fabrizio D’Ascenzo and Gaetano Maria De Ferrari

    Citation: BMC Cardiovascular Disorders 2020 20:29

    Content type: Case report

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  13. TAB2 is an activator of MAP 3 K7/TAK1, which is required for the IL-1 induced signal pathway. Microdeletions encompassing TAB2 have been detected in various patients with congenital heart defects (CHD), indicatin...

    Authors: Jia Chen, Huizhen Yuan, Kang Xie, Xinrong Wang, Linglong Tan, Yongyi Zou, Yan Yang, Lu Pan, Junfang Xiao, Ge Chen and Yanqiu Liu

    Citation: BMC Cardiovascular Disorders 2020 20:27

    Content type: Case report

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  14. Sarcoidosis is a systemic granulomatous disease that may affect the myocardium. This study evaluated the diagnostic and prognostic value of 2-dimensional speckle tracking echocardiography in cardiac sarcoidosi...

    Authors: Cristina Di Stefano, Giulia Bruno, Maria C. Arciniegas Calle, Gayatri A. Acharya, Lynn M. Fussner, Patompong Ungprasert, Leslie T. Cooper Jr, Lori A. Blauwet, Jay H. Ryu, Patricia A. Pellikka, Eva M. Carmona Porquera and Hector R. Villarraga

    Citation: BMC Cardiovascular Disorders 2020 20:21

    Content type: Research article

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  15. Acute heart failure is a rapid onset of new or worsening of signs and symptoms of heart failure that requires hospitalization or a visit to the emergency department. The aim of this study was to evaluate treat...

    Authors: Mulubirhan Tirfe, Teshome Nedi, Desalew Mekonnen and Alemseged Beyene Berha

    Citation: BMC Cardiovascular Disorders 2020 20:16

    Content type: Research article

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  16. Both acute myocardial infarction and acute pulmonary embolism are distinct medical urgencies while they may conincide. Leriche’s syndrome is a relatively rare aortoiliac occlusive disease characterized by clau...

    Authors: Xuanqi An, Rui Fu, Zhihui Zhao, Xinhai Ni, Changming Xiong, Xiansheng Cheng and Zhihong Liu

    Citation: BMC Cardiovascular Disorders 2020 20:26

    Content type: Case report

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  17. Cardiorenal syndrome (CRS) is a group of pathophysiological disorders affecting heart and kidneys.

    Authors: E. Hryniewiecka, T. Hryniewiecki, J. Różański, T. Pilecki, R. Zagożdżon, T. Orłowski, M. Gołębiowski, L. Pączek, K. Mucha and B. Foroncewicz

    Citation: BMC Cardiovascular Disorders 2020 20:20

    Content type: Case report

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  18. It has been reported that oral anticoagulation (OAC) is underused among Chinese patients with non-valvular atrial fibrillation (NVAF). Non-vitamin K antagonist oral anticoagulants (NOAC) have been recommended ...

    Authors: Ting Liu, Hui-li Yang, Lan Gu, Jie Hui, Ojo Omorogieva, Meng-xiao Ren and Xiao-hua Wang

    Citation: BMC Cardiovascular Disorders 2020 20:22

    Content type: Research article

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  19. End-stage renal disease (ESRD) patients are at high cardiovascular risk, and myocardial fibrosis (MF) accounts for most of their cardiac events. The purpose of this study is to investigate the prognostic value...

    Authors: Hua-yan Xu, Zhi-gang Yang, Yi Zhang, Wan-lin Peng, Chun-chao Xia, Zhen-lin Li, Yong He, Rong Xu, Li Rao, Ying Peng, Yu-ming Li, Hong-ling Gao and Ying-kun Guo

    Citation: BMC Cardiovascular Disorders 2020 20:12

    Content type: Research article

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  20. Preclinical studies indicate iron deficiency (ID) plays an important role in cardiac remodelling. However, the relationship between ID and cardiac remodelling remains unknown in clinical setting. This retrospe...

    Authors: Yan Chen, Jing Wan, Haidan Xia, Ya Li, Yufeng Xu, Haiyan Lin and Hassah Iftikhar

    Citation: BMC Cardiovascular Disorders 2020 20:4

    Content type: Research article

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  21. Chymase is the major angiotensin II (Ang II)-forming enzyme in cardiovascular tissue, with an important role in atrial remodeling. This study aimed to examine the association between chymase 1 gene (CMA1) polymor...

    Authors: Dongchen Zhou, Yuewei Chen, Jiaxin Wu, Jiabo Shen, Yushan Shang, Liangrong Zheng and Xudong Xie

    Citation: BMC Cardiovascular Disorders 2019 19:321

    Content type: Research article

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  22. Non-cardiac surgery for hypertrophic obstructive cardiomyopathy (HOCM) is considered to require meticulous perioperative care. β-blockers are considered the first-line drugs for patients with HOCM, and they pl...

    Authors: Yoichi Imori, Hitoshi Takano, Hiroshi Mase, Junya Matsuda, Hideto Sangen, Yuki Izumi, Yukichi Tokita, Takeshi Yamamoto and Wataru Shimizu

    Citation: BMC Cardiovascular Disorders 2019 19:316

    Content type: Research article

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  23. Transesophageal echocardiography may be used to assess pulmonary veins for atrial fibrillation ablation. No study focused on the role of transthoracic echocardiography (TTE) in evaluating the diameter and anat...

    Authors: Qing-Qing Dong, Wen-Yi Yang, Ya-Ping Sun, Qian Zhang, Guang Chu, Gen-Qing Zhou, Gang Chen, Song-Wen Chen, Shao-Wen Liu and Fang Wang

    Citation: BMC Cardiovascular Disorders 2019 19:315

    Content type: Research article

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  24. Whipple’s disease is a clinically relevant multi-system disorder that is often undiagnosed given its elusive nature. We present an atypical case of Whipple’s disease involving pan-valvular endocarditis and con...

    Authors: Christina S. Thornton, Yinong Wang, Martin Köebel, Kathryn Bernard, Tamara Burdz, Andrew Maitland, Jose G. Ferraz, Paul L. Beck and Andre Ferland

    Citation: BMC Cardiovascular Disorders 2019 19:312

    Content type: Case report

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  25. The most significant manifestation of heart failure is exercise intolerance. This systematic review and meta-analysis was performed to investigate whether dipeptidyl peptidase-4 (DPP-4) inhibitors or glucagon-lik...

    Authors: Chengcong Chen, Ying Huang, Yongmei Zeng, Xiyan Lu and Guoqing Dong

    Citation: BMC Cardiovascular Disorders 2019 19:311

    Content type: Research article

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  26. The optimal level of heart rate (HR) control in patients with atrial fibrillation (AF) is unknown. To assess the effect of rate control on cardiopulmonary exercise capacity and quality of life (QoL) in permane...

    Authors: Fei She, Yuan Ma, Yi Li, Lei Li, Weixian Xu, Hongyan Wang and Ming Cui

    Citation: BMC Cardiovascular Disorders 2019 19:308

    Content type: Research article

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  27. Calcific aortic valve disease (CAVD) is an atheroinflammatory process; finally it leads to progressive calcification of the valve. There is no effective pharmacological treatment for CAVD and many of the under...

    Authors: Jonna Weisell, Pauli Ohukainen, Juha Näpänkangas, Steffen Ohlmeier, Ulrich Bergmann, Tuomas Peltonen, Panu Taskinen, Heikki Ruskoaho and Jaana Rysä

    Citation: BMC Cardiovascular Disorders 2019 19:306

    Content type: Research article

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  28. Endomyocardial fibrosis (EMF) represents the most common cause of restrictive cardiomyopathy worldwide. Despite a high prevalence in tropical regions, it occasionally occurs in patients who have never visited ...

    Authors: Gernot Wagner, Markus Haumer, Gerhard Poelzl, Dominik Wiedemann, Andreas Kliegel, Robert Ullrich, Gerald Gartlehner, Andreas Zuckermann, Ludwig Müller, Harald Mayr and Deddo Moertl

    Citation: BMC Cardiovascular Disorders 2019 19:302

    Content type: Case report

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  29. The optimal dosage for cryoablation of atrial fibrillation (Cryo-AF) is still unknown. To evaluate the efficacy of an individualized freeze duration, we compared the clinical outcome of patients treated with a...

    Authors: Jun Ding, Jing Xu, Wei Ma, Bingwei Chen, Peigen Yang, Yu Qi, Shan Sun and Aijuan Cheng

    Citation: BMC Cardiovascular Disorders 2019 19:299

    Content type: Research article

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  30. Patients with some mutations in the lamin A/C (LMNA) gene are characterized by the presence of dilated cardiomyopathy (DCM), conduction abnormalities, ventricular tachyarrhythmias (VT), and sudden cardiac death (...

    Authors: Tetsuro Yokokawa, Shohei Ichimura, Naoko Hijioka, Takashi Kaneshiro, Akiomi Yoshihisa, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Osamu Suzuki, Seiko Ohno, Takeshi Aiba, Hiroshi Ohtani and Yasuchika Takeishi

    Citation: BMC Cardiovascular Disorders 2019 19:298

    Content type: Case report

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  31. Late gadolinium enhancement (LGE) using cardiac magnetic resonance (CMR) characterizes myocardial disease and predicts an adverse cardiovascular (CV) prognosis. Myocardial abnormalities, are present in early c...

    Authors: Anna M. Price, Manvir K. Hayer, Ravi Vijapurapu, Saad A. Fyyaz, William E. Moody, Charles J. Ferro, Jonathan N. Townend, Richard P. Steeds and Nicola C. Edwards

    Citation: BMC Cardiovascular Disorders 2019 19:295

    Content type: Research article

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  32. Patients after aortic coarctation (CoA) repair show impaired aortic bioelasticity and altered left ventricular (LV) mechanics, predisposing diastolic dysfunction. Our purpose was to assess aortic bioelasticity...

    Authors: Theresa Pieper, Heiner Latus, Dietmar Schranz, Joachim Kreuder, Bettina Reich, Kerstin Gummel, Helge Hudel and Inga Voges

    Citation: BMC Cardiovascular Disorders 2019 19:286

    Content type: Research article

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  33. Advanced echocardiography techniques such as speckle tracking imaging are sensitive diagnostic tools frequently used in various clinical and scientific scenarios. Importantly, imperfect reproducibility and dep...

    Authors: Kai O. Hensel

    Citation: BMC Cardiovascular Disorders 2019 19:281

    Content type: Commentary

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  34. Diabetes mellitus (DM) has been demonstrated to be a strong risk factor for development and perpetuation of atrial fibrillation (AF). However, how DM and glycemic control affect the pathogenesis of AF has not ...

    Authors: Qing Wang, Jing Wang, Pei Wang, Liaoyuan Wang, Lanting Jia, Xinyu Ling, Wang Xi, Jie Min, Hua Shen, Jian Xiao, Jinxiang Yuan and Zhinong Wang

    Citation: BMC Cardiovascular Disorders 2019 19:278

    Content type: Research article

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  35. Evidences regarding the associations between maternal upper respiratory tract infection/influenza during pregnancy and the risk of congenital heart disease (CHD) is still controversial. This study was specific...

    Authors: Y. Q. Xia, K. N. Zhao, A. D. Zhao, J. Z. Zhu, H. F. Hong, Y. L. Wang and S. H. Li

    Citation: BMC Cardiovascular Disorders 2019 19:277

    Content type: Research article

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  36. Several studies have reported on atrial fibrillation (AF) outcomes, including thromboembolism in patients with paroxysmal and non-paroxysmal AF; however the findings still remain controversial on whether risks...

    Authors: Ying Wang, Chang-Sheng Ma, Xin Du, Liu He, Jie Li, Guo-Hong Wang, Dan Wen, Jian-Zeng Dong, Jian-Hong Pan and Gregory Y. H. Lip

    Citation: BMC Cardiovascular Disorders 2019 19:283

    Content type: Research article

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  37. Left ventricular global longitudinal strain (GLS) with cardiovascular magnetic resonance (CMR) is an important prognostic biomarker. Its everyday clinical use is limited due to methodological and postprocessin...

    Authors: Robert Heinke, Faraz Pathan, Melanie Le, Tommaso D’Angelo, Lea Winau, Christophe Arendt, Thomas J. Vogl, Andreas Zeiher, Eike Nagel and Valentina O. Puntmann

    Citation: BMC Cardiovascular Disorders 2019 19:267

    Content type: Research article

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  38. High risk of embolic events exists in both patients with chronic atrial fibrillation (AF) and patients in the perioperative period of ablation (effective treatment for AF). Therefore, anticoagulant therapy is ...

    Authors: Jian Yang, Xuan Zhang, Xi-ying Wang, Chi Zhang, Song-zan Chen and Shen-Jiang Hu

    Citation: BMC Cardiovascular Disorders 2019 19:261

    Content type: Research article

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  39. Depression is associated with increased mortality and poor prognosis in patients with cardiovascular disease (CVD). However, little is known about the patient characteristics associated with new onset post hea...

    Authors: Serdar Sever, Patrick Doherty, Alexander Stephen Harrison and Su Golder

    Citation: BMC Cardiovascular Disorders 2019 19:256

    Content type: Research article

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  40. The PhysioHeart™ is a mature acute platform, based isolated slaughterhouse hearts and able to validate cardiac devices and techniques in working mode. Despite perfusion, myocardial edema and time-dependent fun...

    Authors: Benjamin Kappler, Carlos A. Ledezma, Sjoerd van Tuijl, Veronique Meijborg, Bastiaan J. Boukens, Bülent Ergin, P. J. Tan, Marco Stijnen, Can Ince, Vanessa Díaz-Zuccarini and Bas A. J. M. de Mol

    Citation: BMC Cardiovascular Disorders 2019 19:254

    Content type: Research article

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  41. Pulmonary embolism (PE) is associated to high mortality rate worldwide. However, the diagnosis of PE often results inaccurate. Many cases of PE are incorrectly diagnosed or missed and they are often associated...

    Authors: Gelsomina Mansueto, Dario Costa, Emanuele Capasso, Federica Varavallo, Giuseppina Brunitto, Rosanna Caserta, Salvatore Esposito, Massimo Niola, Celestino Sardu, Raffaele Marfella, Claudio Napoli and Mariano Paternoster

    Citation: BMC Cardiovascular Disorders 2019 19:250

    Content type: Research article

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  42. Conventional pharmacologic therapies aim to reduce fluid overload in advanced heart failure (HF) represented by intravenous (IV) loop diuretics (LDs) have sometimes not so efficacious and been reported to have...

    Authors: Ying Yang, Chao Shen, Jiangting Lu, Fen Xu, Jinshan Tong, Jiangfen Jiang and Guosheng Fu

    Citation: BMC Cardiovascular Disorders 2019 19:249

    Content type: Study protocol

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  43. The leading cause of mortality of thalassemia major patients is iron overload cardiomyopathy. Early diagnosis with searching for left ventricular diastolic dysfunction before the systolic dysfunction ensued mi...

    Authors: Benjaporn Chinprateep, Nithima Ratanasit, Yodying Kaolawanich, Khemajira Karaketklang, Pairash Saiviroonporn, Vip Viprakasit and Rungroj Krittayaphong

    Citation: BMC Cardiovascular Disorders 2019 19:245

    Content type: Research article

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  44. Care coordination between general practitioners (GPs) and cardiovascular specialists is expected to play a key role in establishing appropriate oral anticoagulant (OAC) treatment in atrial fibrillation (AF) pa...

    Authors: Fumiko Ono, Sayako Akiyama, Akifumi Suzuki, Yoshinobu Ikeda, Akira Takahashi, Hitoshi Matsuoka, Masahiro Sasaki, Tomonori Okamura and Nariaki Yoshihara

    Citation: BMC Cardiovascular Disorders 2019 19:235

    Content type: Research article

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  45. Ventricular arrhythmias (VAs) arising from the origin above pulmonary valve lack comprehensive investigation. This study aimed to disclose the characteristics and radiofrequency catheter ablation (RFCA) outcom...

    Authors: Jin Li, Cheng Zheng, Zhi-Rui Liu, Jun Ma, Ge Jin, Wei-Qian Lin, Yao-Yao Wang and Jia-Feng Lin

    Citation: BMC Cardiovascular Disorders 2019 19:233

    Content type: Research article

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  46. Because of previous ventricular arrhythmia (VA) episodes, patients with implantable cardioverter-defibrillator (ICD) for secondary prevention (SP) are generally considered to have a higher burden of VAs than p...

    Authors: You Zhou, Shuang Zhao, Keping Chen, Wei Hua, Yangang Su, Silin Chen, Zhaoguang Liang, Wei Xu and Shu Zhang

    Citation: BMC Cardiovascular Disorders 2019 19:230

    Content type: Research article

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  47. Transcatheter closure of perimembranous ventricular septal defects is one of the greatest challenges in interventional cardiology. Short- and midium-term follow-up data for large samples are limited. This repo...

    Authors: Hao Li, Youyang Shi, Songyue Zhang, Yue Ren, Xing Rong, Zhenquan Wang, Tianhe Xia, Tingting Wu, Haitang Xu, Yaoyao Yan, Yi Zhan, Maoping Chu and Rongzhou Wu

    Citation: BMC Cardiovascular Disorders 2019 19:222

    Content type: Research article

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  48. Patients with reduced ejection fraction have high rates of mortality and readmission after hospitalization for heart failure. In Taiwan, heart failure disease management programs (HFDMPs) have proven effective...

    Authors: Shyh-Ming Chen, Yen-Nan Fang, Lin-Yi Wang, Ming-Kung Wu, Po-Jui Wu, Tsung-Hsun Yang, Yung-Lung Chen and Chi-Ling Hang

    Citation: BMC Cardiovascular Disorders 2019 19:220

    Content type: Research article

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  49. Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intens...

    Authors: Dawud Abawi, Alessandro Faragli, Michael Schwarzl, Martin Manninger, David Zweiker, Karl-Patrik Kresoja, Jochen Verderber, Birgit Zirngast, Heinrich Maechler, Paul Steendijk, Burkert Pieske, Heiner Post and Alessio Alogna

    Citation: BMC Cardiovascular Disorders 2019 19:217

    Content type: Research article

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