Skip to main content


Non-coronary artery cardiac disease

Section edited by Michel Noutsias

This section concerns all aspects of non-coronary artery cardiac disease including but not limited to: arrhythmias, congenital cardiac disease and cardiomyopathies. The section considers articles concerning the prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

Page 1 of 8

  1. Content type: Research article

    Non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) have substantially improved anticoagulation therapy for prevention of stroke and systemic embolism in patients with atrial fibrillation (AF). The avai...

    Authors: Raffaele De Caterina, Peter Kelly, Pedro Monteiro, Jean Claude Deharo, Carlo de Asmundis, Esteban López-de-Sá, Thomas W. Weiss, Johannes Waltenberger, Jan Steffel, Joris R. de Groot, Pierre Levy, Ameet Bakhai, Wolfgang Zierhut, Petra Laeis, Michael Kerschnitzki, Paul-Egbert Reimitz…

    Citation: BMC Cardiovascular Disorders 2019 19:165

    Published on:

  2. Content type: Research article

    Atrial fibrillation (AF) and related atrial tachyarrhythmias (AT), including type I atrial flutter (AFL) are frequently observed in patients with pulmonary hypertension (PH). Their relationship to hemodynamic ...

    Authors: Zdenka Fingrova, Stepan Havranek, David Ambroz, Pavel Jansa and Ales Linhart

    Citation: BMC Cardiovascular Disorders 2019 19:157

    Published on:

  3. Content type: Case report

    Continuous-flow left ventricular assist devices (LVADs) improve survival and morbidity in patients with stage D heart failure. Management of LVADs for longer durations is necessary in some clinical settings, a...

    Authors: Chie Bujo, Eisuke Amiya, Masaru Hatano, Masaki Tsuji, Hisataka Maki, Yumiko Hosoya, Emi Fujii, Tatsuya Kamon, Toshiya Kojima, Kan Nawata, Osamu Kinoshita, Mitsutoshi Kimura, Minoru Ono and Issei Komuro

    Citation: BMC Cardiovascular Disorders 2019 19:151

    Published on:

  4. Content type: Research article

    Little is known about the ICD performance using enhanced detection algorithms in unselected, non-trial patients. Performance of recent generation ICD equipped with SmartShock™ technology (SST) for detection an...

    Authors: François Regoli, Denis Graf, Beat Schaer, Firat Duru, Peter Ammann, Lorenza Mangoni di S. Stefano, Barbara Naegli, Haran Burri, Rainer Zbinden, Nazmi Krasniqi and Martin Fromer

    Citation: BMC Cardiovascular Disorders 2019 19:146

    Published on:

  5. Content type: Research article

    Clinical trials have demonstrated that direct oral anticoagulants (DOACs) are at least non-inferior to warfarin in reducing the risk of stroke/systemic embolism (SE) among patients with non-valvular atrial fib...

    Authors: Kiran Gupta, Jeffrey Trocio, Allison Keshishian, Qisu Zhang, Oluwaseyi Dina, Jack Mardekian, Anagha Nadkarni and Thomas C Shank

    Citation: BMC Cardiovascular Disorders 2019 19:142

    Published on:

  6. Content type: Research article

    Catheter ablation (CA) and left atrial appendage closure (LAAC) have been combined into a novel one-stop procedure for patients with atrial fibrillation (AF). However, postoperative complications are relativel...

    Authors: Zhonglin Han, Xiang Wu, Zheng Chen, Wengqing Ji, Xuehua Liu, Yu Liu, Wencheng Di, Xiaohong Li, Hongsong Yu, Xinlin Zhang, Biao Xu, Rong Fang Lan and Wei Xu

    Citation: BMC Cardiovascular Disorders 2019 19:138

    Published on:

  7. Content type: Technical advance

    Historically, the majority of insertable cardiac monitor (ICM) procedures were performed in the cardiac catheterization (cath) lab, electrophysiology (EP) lab, or operating room (OR). The miniaturization of IC...

    Authors: Prashanthan Sanders, Christopher Piorkowski, Johannes A. Kragten, Grahame K. Goode, Satish R. Raj, Trang Dinh, M. Rizwan Sohail, Rishi Anand, Angel Moya-Mitjans, Noreli Franco, Kurt Stromberg and John D. Rogers

    Citation: BMC Cardiovascular Disorders 2019 19:132

    Published on:

  8. Content type: Research article

    Gamma-glutamyltransferase (GGT) is a new predictor of cardiovascular diseases. In this study, we aimed to determine its association with ventricular arrhythmias (VAs) in implantable cardioverter-defibrillator ...

    Authors: You Zhou, Shuang Zhao, Keping Chen, Wei Hua and Shu Zhang

    Citation: BMC Cardiovascular Disorders 2019 19:129

    Published on:

  9. Content type: Research article

    Loop diuretics are recommended by clinical practice guidelines to treat volume overload in acute decompensated heart failure (ADHF). The effectiveness of switching furosemide to torsemide versus optimizing the...

    Authors: Alaa Rahhal, Mohamed Omar Saad, Kawthar Tawengi, Abed Al Raouf Assi, Masa Habra and Dalia Ahmed

    Citation: BMC Cardiovascular Disorders 2019 19:127

    Published on:

  10. Content type: Research article

    Information on the role of intermittent fasting (IF) on pathologic cardiac remodeling is scarce. We compared the effects of IF before and after myocardial infarction (MI) on rat cardiac remodeling and survival.

    Authors: K. Okoshi, M. D. M. Cezar, M. A. M. Polin, J. R. Paladino Jr, P. F. Martinez, S. A. Oliveira Jr, A. R. R. Lima, R. L. Damatto, S. A. R. Paiva, L. A. M. Zornoff and M. P. Okoshi

    Citation: BMC Cardiovascular Disorders 2019 19:126

    Published on:

  11. Content type: Research article

    Postoperative atrial fibrillation (POAF) is a common complication in patients with obstructive hypertrophic cardiomyopathy (HOCM) who undergo surgical myectomy. POAF is associated with poor outcome. The role o...

    Authors: Changpeng Song, Shengwei Wang, Ying Guo, Xinxin Zheng, Jie Lu, Xiaonan Fang, Shuiyun Wang and Xiaohong Huang

    Citation: BMC Cardiovascular Disorders 2019 19:122

    Published on:

  12. Content type: Study protocol

    Atrial fibrillation (AF) is caused by different mechanisms but current treatment strategies do not target these mechanisms. Stratified therapy based on mechanistic drivers and biomarkers of AF have the potenti...

    Authors: Winnie Chua, Christina L. Easter, Eduard Guasch, Alice Sitch, Barbara Casadei, Harry J. G. M. Crijns, Doreen Haase, Stéphane Hatem, Stefan Kääb, Lluis Mont, Ulrich Schotten, Moritz F. Sinner, Karla Hemming, Jonathan J. Deeks, Paulus Kirchhof and Larissa Fabritz

    Citation: BMC Cardiovascular Disorders 2019 19:120

    Published on:

  13. Content type: Research article

    In recent years, studies have indicated that vitamin D [25(OH)D3] and other calcium-phosphate (Ca-P) metabolism parameters and their disturbances might be potential new factors that may influence health-related q...

    Authors: Olga Mozenska, Jacek Bil, Agnieszka Segiet and Dariusz A. Kosior

    Citation: BMC Cardiovascular Disorders 2019 19:116

    Published on:

  14. Content type: Research article

    Peripartum cardiomyopathy (PPCM) is a rare but potentially life-threatening complication of pregnancy. There is limited data regarding the predictors of persistent left ventricular (LV) systolic dysfunction. R...

    Authors: Firdevs Aysenur Ekizler and Serkan Cay

    Citation: BMC Cardiovascular Disorders 2019 19:114

    Published on:

  15. Content type: Research article

    Impaired renal function increases the bleeding risk, leading to a conservative prescription and frequent discontinuation of oral anticoagulation in atrial fibrillation patients with chronic kidney disease (CKD...

    Authors: Blerim Luani, Conrad Genz, Joerg Herold, Andreas Mitrasch, Julius Mitusch, Marcus Wiemer, Alexander Schmeißer, Rüdiger C. Braun-Dullaeus and Thomas Rauwolf

    Citation: BMC Cardiovascular Disorders 2019 19:112

    Published on:

  16. Content type: Research article

    The function of deiodinases – selenoproteins converting thyroid hormones may be disturbed by oxidative stress accompanying heart failure. Selenium (Se) may be used by glutathione peroxidase, leading to a lack ...

    Authors: Magdalena Fraczek-Jucha, Katarzyna Zbierska-Rubinkiewicz, Małgorzata Kabat, Krzysztof Plens, Radoslaw Rychlak, Jadwiga Nessler and Andrzej Gackowski

    Citation: BMC Cardiovascular Disorders 2019 19:105

    Published on:

    The Correction to this article has been published in BMC Cardiovascular Disorders 2019 19:133

  17. Content type: Review

    Arrhythmic sudden cardiac death (SCD) represents a major worldwide public health problem accounting for 15–20% of deaths. Risk stratification to identify patients at risk of SCD is crucial in order to implemen...

    Authors: C. Balla, F. Vitali, A. Brieda, F. Gualandi, A. Ferlini, M. Bertini and R. Ferrari

    Citation: BMC Cardiovascular Disorders 2019 19:104

    Published on:

  18. Content type: Case report

    Pulmonary embolism (PE) is a fatal condition, with a subsequent variety of complications. Although rare, the ensuing presentation of atrial fibrillation (AF) secondary to PE is evident in the literature. Howev...

    Authors: Mohammad A. Abdulsalam, Mohammed N. Elganainy and Ahmad J. Abdulsalam

    Citation: BMC Cardiovascular Disorders 2019 19:101

    Published on:

  19. Content type: Research article

    Persistent left superior vena cava (PLSVC) is a rare congenital vascular anomaly. Permanent pacemaker implantation (PPI) in patients with PLSVC can be challenging because of the venous anomalies. We reported a...

    Authors: Teng Li, Qiong Xu, Hong-tao Liao, Dimitrios Asvestas, Konstantinos P. Letsas and Yifu Li

    Citation: BMC Cardiovascular Disorders 2019 19:100

    Published on:

  20. Content type: Research article

    Heart failure (HF) is a common clinical syndrome, particularly in older people, and symptoms can develop gradually. The aim of this study was to explore the role of informal carers in the HF diagnostic process.

    Authors: Frances Bell-Davies, Clare Goyder, Nicola Gale, F. D. Richard Hobbs and Clare J. Taylor

    Citation: BMC Cardiovascular Disorders 2019 19:92

    Published on:

  21. Content type: Research article

    The ECG characteristics of the distal coronary venous system ventricular arrhythmias (VAs) share common features with VAs arising from the aortic cusps or the endocardial left ventricular outflow tract (LVOT) ...

    Authors: Teng Li, Qiong Xu, Xian-zhang Zhan, Yu-mei Xue, Hong-tao Liao, Yi-fu Li, Konstantinos P. Letsas and Shu-lin Wu

    Citation: BMC Cardiovascular Disorders 2019 19:90

    Published on:

  22. Content type: Research article

    In atrial fibrillation (AF), there are known sex and sociodemographic disparities in clinical outcomes such as stroke. We investigate whether disparities also exist with respect to patient-reported outcomes. W...

    Authors: Kelly T. Gleason, Cheryl R. Dennison Himmelfarb, Daniel E. Ford, Harold Lehmann, Laura Samuel, Hae Ra Han, Sandeep K. Jain, Gerald V. Naccarelli, Vikas Aggarwal and Saman Nazarian

    Citation: BMC Cardiovascular Disorders 2019 19:85

    Published on:

  23. Content type: Research article

    Subclinical thyroid dysfunction whose typical patterns include subclinical hypothyroidism and subclinical hyperthyroidism, has been indicated to be associated with an increased risk of heart failure (HF). Howe...

    Authors: Guodong Yang, Ya Wang, Aiqun Ma and Tingzhong Wang

    Citation: BMC Cardiovascular Disorders 2019 19:83

    Published on:

  24. Content type: Research article

    The impact of cerebral microbleeds on the safety of antithrombotic therapy has recently received considerable attention. We investigated the safety of antithrombotic therapy in patients with cerebral microblee...

    Authors: Jiayu Wang, Jia Zhang, Yuan Shen and Xiaowei Xu

    Citation: BMC Cardiovascular Disorders 2019 19:77

    Published on:

  25. Content type: Research article

    Myocardial flow reserve (MFR, stress/rest myocardial blood flow) is a strong marker of myocardial vasomotor function. MFR is a predictor of adverse cardiac events in patients with non-ischemic systolic heart f...

    Authors: Christina Byrne, Philip Hasbak, Andreas Kjaer, Jens Jakob Thune and Lars Køber

    Citation: BMC Cardiovascular Disorders 2019 19:68

    Published on:

  26. Content type: Research article

    Atrial fibrillation (AF) without other stroke risk factors is assumed to have a low annual stroke risk comparable to patients without AF. Therefore, current clinical guidelines do not recommend oral anticoagul...

    Authors: Juliane Herm, Johannes Schurig, Martin R. Martinek, Reinhard Höltgen, Alexander Schirdewan, Paulus Kirchhof, Marcus Wieczorek, Helmut Pürerfellner, Peter U. Heuschmann, Jochen B. Fiebach and Karl Georg Haeusler

    Citation: BMC Cardiovascular Disorders 2019 19:58

    Published on:

  27. Content type: Research article

    The 2014 ACC/AHA guidelines redefined the strategy for LDL-cholesterol (LDL-C) treatment. According to data from evidence-based studies, the basis for earlier therapeutic recommendations for LDL-C target level...

    Authors: Albert Császár

    Citation: BMC Cardiovascular Disorders 2019 19:57

    Published on:

  28. Content type: Research article

    Left ventricular diastolic dysfunction has been shown to associate with increased risk of atrial fibrillation (AF). We aimed to examine the predictors of AF in individuals with preclinical diastolic dysfunctio...

    Authors: Dan L. Li, Renato Quispe, Nidhi Madan, Lili Zhang and Cynthia C. Taub

    Citation: BMC Cardiovascular Disorders 2019 19:47

    Published on:

  29. Content type: Research article

    This study aimed to investigate whether age at complete repair of tetralogy of Fallot (TOF) impacts postoperative morbidity and length of hospital stay in infants less than 365 days of age.

    Authors: Shihai Yang, Linlin Wen, Shuguang Tao, Jiangrong Gu, Jiangang Han, Junping Yao and Jianming Wang

    Citation: BMC Cardiovascular Disorders 2019 19:46

    Published on:

  30. Content type: Research article

    The mechanically expandable Lotus Valve System is a fully repositionable and retrievable valve with an adaptive seal to minimize paravalvular leak (PVL). The aim of this study was to evaluate the short- and lo...

    Authors: Karolina Berntorp, Sasha Koul, Shahab Nozohoor, Jan Harnek, Henrik Bjursten and Matthias Götberg

    Citation: BMC Cardiovascular Disorders 2019 19:44

    Published on:

  31. Content type: Research article

    Structural remodeling is critical to the initiation and maintenance of atrial fibrillation (AF). IGF1, insulin like growth factor 1, has been recognized as contributor to fibrosis. However, the roles and mecha...

    Authors: Jiangrong Wang, Zhan Li, Juanjuan Du, Jianhua Li, Yong Zhang, Jing Liu and Yinglong Hou

    Citation: BMC Cardiovascular Disorders 2019 19:40

    Published on:

  32. Content type: Research article

    Atrial fibrillation (AF) patients are routinely prescribed medications to prevent and treat complications, including those from common co-occurring comorbidities. However, adherence to such medications may be ...

    Authors: Stephanie R. Reading, Mary Helen Black, Daniel E. Singer, Alan S. Go, Margaret C. Fang, Natalia Udaltsova, Teresa N. Harrison, Rong X. Wei, In-Lu Amy Liu and Kristi Reynolds

    Citation: BMC Cardiovascular Disorders 2019 19:38

    Published on:

  33. Content type: Research article

    Interatrial block (IAB) is an ECG indicator of atrial fibrosis related to atrial remodeling and thrombus formation thus leading to embolic stroke and increasing mortality. We aimed to assess weather IAB predic...

    Authors: M. A. Baturova, A. Lindgren, Y. V. Shubik, J. Carlson and P. G. Platonov

    Citation: BMC Cardiovascular Disorders 2019 19:37

    Published on:

  34. Content type: Research article

    Previous randomized controlled trials (RCT)s showed similar outcomes in patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) treated with anti-arrhythmic drugs (AAD) ...

    Authors: Ahmed AlTurki, Riccardo Proietti, Ahmed Dawas, Hasan Alturki, Thao Huynh and Vidal Essebag

    Citation: BMC Cardiovascular Disorders 2019 19:18

    Published on:

  35. Content type: Research article

    Peripheral artery disease (PAD) is often asymptomatic but increases the risk of developing cardiovascular events. Due to the uncertainties regarding the quality of related guidelines and a lack of clear-cut ev...

    Authors: Qinchang Chen, Lingling Li, Qingui Chen, Xixia Lin, Yonghui Li, Kai Huang and Chen Yao

    Citation: BMC Cardiovascular Disorders 2019 19:17

    Published on:

  36. Content type: Research article

    LV systolic dysfunction presents an elevated risk of thromboembolism. Previous studies demonstrated low left ventricular ejection fraction (LVEF), ischemic cardiomyopathy and increased myocardial scarring as i...

    Authors: Yodying Kaolawanich and Thananya Boonyasirinant

    Citation: BMC Cardiovascular Disorders 2019 19:15

    Published on:

  37. Content type: Research article

    High-dose steroids and intravenous immunoglobulin (IVIG) are controversial treatments for pediatric patients with acute myocarditis. This study aimed to investigate their efficacies in the Taiwanese pediatric ...

    Authors: Ming-Shyan Lin, Yu-Hsiang Tseng, Mei-Yen Chen, Chang-Min Chung, Ming-Horng Tsai, Po-Chang Wang, Jung-Jung Chang, Tien-Hsing Chen and Yu-Sheng Lin

    Citation: BMC Cardiovascular Disorders 2019 19:10

    Published on:

  38. Content type: Case report

    Takotsubo cardiomyopathy (TCM) is a brief ventricular dysfunction that usually occurs after emotional or physical stress. Here, we report a patient who underwent cardiac surgery and then developed TCM during t...

    Authors: Jia-Hui Zeng, Wei Li, Feng-Juan Yao, Dong-Hong Liu, Cui-Ling Li, Yan-Qiu Liu, Rui Fan, Min Ye and Hong Lin

    Citation: BMC Cardiovascular Disorders 2019 19:9

    Published on:

  39. Content type: Review

    Advances in the medical and surgical management of Tetralogy of Fallot have led to marked increase of the number and age of survivors. Imaging in patients with Tetralogy of Fallot plays a crucial role in the d...

    Authors: Sotiria C. Apostolopoulou, Athanassios Manginas, Nikolaos L. Kelekis and Michel Noutsias

    Citation: BMC Cardiovascular Disorders 2019 19:7

    Published on:

  40. Content type: Research article

    There are limited data about modes of death and major adverse cardiovascular events (MACEs) in patients with hypertrophic cardiomyopathy (HCM) in South East Asian population. The aim of the study was to examin...

    Authors: Nattakorn Songsirisuk, Veraprapas Kittipibul, Nilubon Methachittiphan, Vorawan Charoenattasil, Nath Zungsontiporn, Ittikorn Spanuchart, Saranya Buppajarntham, Charoen Mankongpaisarnrung, Sudarat Satitthummanid, Suphot Srimahachota, Pairoj Chattranukulchai, Smonporn Boonyaratavej Songmuang and Sarinya Puwanant

    Citation: BMC Cardiovascular Disorders 2019 19:1

    Published on:

  41. Content type: Research article

    Noninvasive diagnosis of allograft rejection in heart transplant recipients is challenging. The utility of 2-dimensional speckle-tracking echocardiography (2D-STE) to predict severe rejection in heart transpla...

    Authors: Andrew S. Tseng, Umama S. Gorsi, Sergio Barros-Gomes, Fletcher A. Miller, Patricia A. Pellikka, Alfredo L. Clavell and Hector R. Villarraga

    Citation: BMC Cardiovascular Disorders 2018 18:241

    Published on:

  42. Content type: Case report

    Behcet’s disease (BD) is a systemic vasculitis characterized by oral and genital aphthosis, and ocular and skin lesions. The disease is involved in vascular, gastrointestinal, and central nervous systems. Vasc...

    Authors: Fang Jiang, Hui Xiang and Zhi-Yong Peng

    Citation: BMC Cardiovascular Disorders 2018 18:238

    Published on:

  43. Content type: Debate

    Transcatheter aortic valve implantation (TAVI) has become an established therapeutic option for patients with symptomatic, severe aortic valve stenosis. Ageing of the Western and Asian population and expansion...

    Authors: Manik Chopra, Ngai H. V. Luk, Ole De Backer and Lars Søndergaard

    Citation: BMC Cardiovascular Disorders 2018 18:231

    Published on:

  44. Content type: Research article

    The literature suggests that comorbid depression, defined in this paper as a history of depression prior to a cardiovascular event, has an impact on later onset depression as well as constituting increased ris...

    Authors: Serdar Sever, Su Golder and Patrick Doherty

    Citation: BMC Cardiovascular Disorders 2018 18:230

    Published on:

  45. Content type: Case report

    Takotsubo syndrome (TTS) is an acute cardiac condition with reversible heart failure which is often triggered by psychological and physical stressful events. Although pulmonary embolism (PE) was reported as a ...

    Authors: Qi Jin, Qin Luo, Zhihui Zhao, Qing Zhao, Xue Yu, Lu Yan, Liu Gao and Zhihong Liu

    Citation: BMC Cardiovascular Disorders 2018 18:229

    Published on:

  46. Content type: Research article

    Cardiac arrhythmias (CA) are very common and may occur with or without heart disease. Causes of these disturbances can be components of the metabolic syndrome (MetS) or deficits of micronutrients especially ma...

    Authors: Elke Parsi, Norman Bitterlich, Anne Winkelmann, Daniela Rösler and Christine Metzner

    Citation: BMC Cardiovascular Disorders 2018 18:220

    Published on: