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Non-coronary artery cardiac disease

Section edited by Michel Noutsias

This section concerns all aspects of non-coronary artery cardiac disease including but not limited to: arrhythmias, congenital cardiac disease and cardiomyopathies. The section considers articles concerning the prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Aortic stiffness is an independent predictor of cardiovascular (CV) events and mortality. However, no data exists for the prognosis of combined aortic stiffness and myocardial ischemia. Using cardiac magnetic ...

    Authors: Yodying Kaolawanich and Thananya Boonyasirinant

    Citation: BMC Cardiovascular Disorders 2020 20:287

    Content type: Research article

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  2. Management of warfarin-associated major haemorrhage in prosthetic valve diseases is difficult as there is a fine line between haemorrhage and thrombosis. An individual’s propensity towards thrombosis, such as ...

    Authors: Mustafa Oguz, Ahmet Ayaz and Mehmet Emin Adin

    Citation: BMC Cardiovascular Disorders 2020 20:286

    Content type: Case report

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  3. Underweight or obese status influences the prognosis of atrial fibrillation (AF). However, the association between stratification of body mass index (BMI) and in-hospital outcomes in patients with AF, remains ...

    Authors: Fuxue Deng, Yan Zhang, Qiang Zhao, Yangyang Deng, Shanshan Gao, Lisha Zhang, Mengya Dong, Zuyi Yuan and Xinjun Lei

    Citation: BMC Cardiovascular Disorders 2020 20:270

    Content type: Research article

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  4. Peripartum cardiomyopathy (PPCM) is life-threatening heart disease. However, the causes and pathogenesis of PPCM remain unclear. Previous studies found that β1 adrenoceptor antibodies (β1AA) had possible invol...

    Authors: Linying Shi, Jia Liu, Yuan Zhang, Mulei Chen and Jiamei Liu

    Citation: BMC Cardiovascular Disorders 2020 20:269

    Content type: Research article

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  5. Cardiovascular disease is second only to cancer recurrence as a determinant of lifespan in cancer survivors, and cancer therapy-related cardiac dysfunction is a clinically important risk factor. We aim to inve...

    Authors: Yoo Jin Hong, Gun Min Kim, Kyunghwa Han, Pan Ki Kim, Su An Lee, Eunkyung An, Ji Yeon Lee, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Min Jung Kim and Byoung Wook Choi

    Citation: BMC Cardiovascular Disorders 2020 20:264

    Content type: Study protocol

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  6. The benefit of combining aspirin and direct oral anticoagulants on the reduction of cardiovascular events in atrial fibrillation or flutter is not well studied. We aimed to assess whether concurrent aspirin an...

    Authors: Ahmad Said, Scott Keeney, Marsel Matka, Adam Hafeez, Julie George and Alexandra Halalau

    Citation: BMC Cardiovascular Disorders 2020 20:263

    Content type: Research article

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  7. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a potential biomarker for monitoring the status of heart failure. However, the optimal monitoring interval of NT-proBNP is unknown. This study sought to...

    Authors: Zhehao Dai, Taku Asano, Osamu Takahashi, Nobuyuki Komiyama and Sachiko Ohde

    Citation: BMC Cardiovascular Disorders 2020 20:262

    Content type: Research article

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  8. One out of seven patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) may be affected by transthyretin cardiac amyloidosis (ATTR-CA), mostly presenting with low-fl...

    Authors: Guglielmo Gallone, Federico Landra, Fabrizio D’Ascenzo, Federico Conrotto, Roberta Casoni, Francesco Bruno, Pierluigi Omedè, Gianluca Alunni, Alessandro Andreis, Alessandro Vairo, Mauro Giorgi, Antonella Fava and Gaetano Maria De Ferrari

    Citation: BMC Cardiovascular Disorders 2020 20:261

    Content type: Case report

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  9. Heart failure is one of leading cause of death worldwide. However, the transcriptional profiling of heart failure is unclear. Moreover, the signaling pathways and transcription factors involving the heart fail...

    Authors: Haiwei Wang, Xinrui Wang, Liangpu Xu and Hua Cao

    Citation: BMC Cardiovascular Disorders 2020 20:250

    Content type: Research article

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  10. Mean platelet volume (MPV) has been identified as an individual risk factor for stroke and thrombosis. Concurrently, ischaemic stroke caused by nonvalvular atrial fibrillation (AF) has attracted increasing att...

    Authors: Meifang Zheng, Shean Chen, Ye Zhu and Xiang Gu

    Citation: BMC Cardiovascular Disorders 2020 20:241

    Content type: Research article

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  11. May-Thurner syndrome (MTS) or Cockett’s syndrome is a rare clinical syndrome, which refers to the compression of the left common iliac vein (LCIV) by right common iliac artery and vertebral body. Complications...

    Authors: Yan Meng, Hao Qin, Qiang Ma, Junbo Zhang, Bo Zhang, Honggang Pang, Qian Yin and Hongyan Tian

    Citation: BMC Cardiovascular Disorders 2020 20:233

    Content type: Case report

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  12. Children with congenital heart disease (CHD) have an elevated risk of future cardiovascular disease but the underlying mechanisms are unclear. Abdominal obesity (measured as waist circumference) is a risk fact...

    Authors: Erin Barbour-Tuck, Natasha G. Boyes, Corey R. Tomczak, Dana S. Lahti, Chantelle L. Baril, Charissa Pockett, Shonah Runalls, Ashok Kakadekar, Scott Pharis, Timothy J. Bradley, Kristi D. Wright and Marta C. Erlandson

    Citation: BMC Cardiovascular Disorders 2020 20:231

    Content type: Research article

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  13. To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to an...

    Authors: Tian-Yuan Xiong, Chang Liu, Yan-Biao Liao, Wen Zheng, Yi-Jian Li, Xi Li, Yuanweixiang Ou, Zi-Jie Wang, Xi Wang, Chang-Ming Li, Zhen-Gang Zhao, Yuan Feng, Xiao-Jing Liu and Mao Chen

    Citation: BMC Cardiovascular Disorders 2020 20:229

    Content type: Research article

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  14. Inflammation and skeletal muscle wasting often coexist in elderly populations, but few studies have examined their relationship in elderly heart failure (HF) patients. This study examined the relationship betw...

    Authors: Masayuki Koshikawa, Masahide Harada, Shunsuke Noyama, Ken Kiyono, Yuji Motoike, Yoshihiro Nomura, Asuka Nishimura, Hideo Izawa, Eiichi Watanabe and Yukio Ozaki

    Citation: BMC Cardiovascular Disorders 2020 20:228

    Content type: Research article

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  15. Although hospital readmission for heart failure (HF) is an issue for both men and women, little is known about differences in readmission rates by sex. Consequently, strategies to optimize readmission reductio...

    Authors: Amy Hoang-Kim, Camilla Parpia, Cassandra Freitas, Peter C. Austin, Heather J. Ross, Harindra C. Wijeysundera, Karen Tu, Susanna Mak, Michael E. Farkouh, Louise Y. Sun, Michael J. Schull, Robin Mason, Douglas S. Lee and Paula A. Rochon

    Citation: BMC Cardiovascular Disorders 2020 20:223

    Content type: Research article

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  16. Atrial fibrillation (AF), one of the most common comorbidities of heart failure (HF), is associated with worse long-term prognosis in HF patients receiving cardiac resynchronization therapy (CRT). However, the...

    Authors: Minsi Cai, Wei Hua, Nixiao Zhang, Shengwen Yang, Yiran Hu, Min Gu, Hongxia Niu and Shu Zhang

    Citation: BMC Cardiovascular Disorders 2020 20:221

    Content type: Research article

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  17. Atrioesophageal fistula (AEF) is the most fatal complication associated with catheter ablation for atrial fibrillation and cannot be easily detected when thoracic contrast-enhanced computed tomography (CT) is ...

    Authors: Bing Rong, Xiquan Zhang, Hui Tian, Hongyu Zhang, Ning Zhong and Jingquan Zhong

    Citation: BMC Cardiovascular Disorders 2020 20:219

    Content type: Case report

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  18. Epicardial adipose tissue (EAT) remodeling and adipocytokines are associated with structural remodeling in atrial fibrillation (AF). However, the role of omentin-1, a novel adipocytokine, in structural remodel...

    Authors: Yubin Chen, Fen Liu, Fei Han, Lizhi Lv, Can-e Tang, Zhongshang Xie and Fanyan Luo

    Citation: BMC Cardiovascular Disorders 2020 20:214

    Content type: Research article

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  19. Right free wall accessory pathways (AP) are difficult to treat with catheter ablation as ablation catheter (AC) instability at the tricuspid annulus often precludes successful procedure.

    Authors: Matevž Jan, Tine Prolič Kalinšek, Jernej Štublar, Matija Jelenc, Andrej Pernat, David Žižek and Nikola Lakič

    Citation: BMC Cardiovascular Disorders 2020 20:210

    Content type: Research article

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  20. In recent years, the field of cardio-oncology has grown worldwide, bringing benefits to cancer patients in terms of survival and quality of life. This study reports the experience of a pioneer cardio-oncology ...

    Authors: Isabela B. S. da S. Costa, Cristina S. Bittar, Silvia M. R. Fonseca, Carolina M. P. D. e Silva, Marilia H. H. dos Santos Rehder, Stéphanie I. Rizk, Cecilia B. B. V. Cruz, Clara S. Figueiredo, Fernanda T. de A. Andrade, Ludmila de A. Barberino, Fernanda A. de S. Costa, Letticya P. Machado, Thalita B. González, Marcel P. C. Almeida, Julia T. Fukushima, Roberto Kalil Filho…

    Citation: BMC Cardiovascular Disorders 2020 20:206

    Content type: Research article

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  21. Non-ischemic cardiomyopathy (NICM) has been associated with a better left ventricle reverse remodeling response and improved clinical outcomes after cardiac resynchronization therapy (CRT). The aims of our stu...

    Authors: Shengwen Yang, Zhimin Liu, Yiran Hu, Ran Jing, Min Gu, Hongxia Niu, Ligang Ding, Anlu Xing, Shu Zhang and Wei Hua

    Citation: BMC Cardiovascular Disorders 2020 20:205

    Content type: Research article

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  22. Heart failure (HF) is relatively common cardiovascular disease with high mortality and morbidity. Although it is associated with many cardiovascular risk factors, the association between nonalcoholic fatty liv...

    Authors: Jae-Hyung Roh, Jae-Hyeong Park, Hanbyul Lee, Yong-Hoon Yoon, Minsu Kim, Yong-Giun Kim, Gyung-Min Park, Jae-Hwan Lee and In-Whan Seong

    Citation: BMC Cardiovascular Disorders 2020 20:204

    Content type: Research article

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  23. Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intoler...

    Authors: Jasmina Medic Spahic, Fabrizio Ricci, Nay Aung, Erik Hallengren, Jonas Axelsson, Viktor Hamrefors, Olle Melander, Richard Sutton and Artur Fedorowski

    Citation: BMC Cardiovascular Disorders 2020 20:190

    Content type: Research article

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  24. Gestational diabetes mellitus (GDM) is the most common metabolic disorder that can occur during pregnancy and is associated with a long-term risk of both maternal and neonatal comorbidities. This study aimed t...

    Authors: Jing Liu, Guang Song, Tao Meng and Ge Zhao

    Citation: BMC Cardiovascular Disorders 2020 20:184

    Content type: Research article

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  25. Heart failure is associated with ventricular dyssynchrony and energetic inefficiency, which can be alleviated by cardiac resynchronization therapy (CRT) with approximately one-third of non-response rate. Thus ...

    Authors: Xue Gong, Zhonghan Sun, Zheyong Huang, Qian Zhou, Ziqing Yu, Xueying Chen, Wenqi Shao, Yan Zheng, Yixiu Liang, Shengmei Qin, Yangang Su and Junbo Ge

    Citation: BMC Cardiovascular Disorders 2020 20:178

    Content type: Research article

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  26. Human epididymis protein 4 (HE4) was proved to be a novel biomarker for left heart failure. The purpose of this exploratory study was to evaluate the role of HE4 in patients with idiopathic pulmonary arterial ...

    Authors: Qi Jin, Yi Tang, Zhihong Liu, Wenlin Xie, Qin Luo, Zhihui Zhao, Qing Zhao, Zhiwei Huang, Xue Yu, Lu Yan, Changming Xiong, Xinhai Ni and Yinkun Yan

    Citation: BMC Cardiovascular Disorders 2020 20:175

    Content type: Research article

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  27. Insertable cardiac monitors are utilized for the diagnosis of arrhythmias and traditionally have been inserted within hospitals. Recent code updates allow for reimbursement of office-based insertions; however,...

    Authors: Khaled Awad, Raul Weiss, Asim Yunus, Jon M. Bittrick, Rajasekhar Nekkanti, Mahmoud Houmsse, Toshimasa Okabe, Teagan Adamson, Crystal Miller and Abdul K. Alawwa

    Citation: BMC Cardiovascular Disorders 2020 20:171

    Content type: Research article

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  28. Catheter ablation (CA) has emerged as an effective treatment for symptomatic atrial fibrillation (AF). However practice patterns and patient factors associated with referral for CA within the first 12 months a...

    Authors: Robert N. D’Angelo, Rahul Khanna, Robert W. Yeh, Laura Goldstein, Iftekhar Kalsekar, Stephen Marcello, Patricia Tung and Peter J. Zimetbaum

    Citation: BMC Cardiovascular Disorders 2020 20:161

    Content type: Research article

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  29. We studied the course of plasma concentrations of 4 cardiovascular biomarkers: natriuretic peptides (BNP, NT-proBNP; mid-regional (MR) pro-atrial NP); and soluble endothelial CD146 (sCD146), in patients with s...

    Authors: Marc Badoz, Mattia Arrigo, Anne-Claire Mogenet, Malha Sadoune, Nicolas Meneveau, Alexandre Mebazaa and Marie-France Seronde

    Citation: BMC Cardiovascular Disorders 2020 20:157

    Content type: Research article

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  30. Danon disease (OMIM 300257) is an X-linked lysosomal storage disorder, characterized by hypertrophic cardiomyopathy (HCM), skeletal myopathy, variable intellectual disability, and other minor clinical features.

    Authors: Valeria Novelli, Antonio Bisignani, Gemma Pelargonio, Guido Primiano, Maria Lucia Narducci, Vincenzo Palmieri, Francesco Danilo Tiziano, Paolo Zeppilli, Serenella Servidei, Filippo Crea and Maurizio Genuardi

    Citation: BMC Cardiovascular Disorders 2020 20:156

    Content type: Case report

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  31. This study aimed to determine whether a focused 2-day cardiac ultrasound training course could enable physicians to obtain and interpret focused cardiac ultrasound (FCU) images from critically ill patients.

    Authors: Hongmin Zhang, Wei He, Hui Lian, Xiukai Chen, Xiaoting Wang, Yangong Chao and Dawei Liu

    Citation: BMC Cardiovascular Disorders 2020 20:151

    Content type: Research article

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  32. The incidence of CHD is the highest among birth defects and is increasing year to year. CHD seriously harms the health of infants and young children and presents a large economic burden to families and society...

    Authors: Lin Na, Bai Q, Zhao Xiumei, Zhuang Lingzi, He Deqin, Zhuang Xuanxuan, Guo Huanhuan, Lin Yuan and Chen Xiujuan

    Citation: BMC Cardiovascular Disorders 2020 20:139

    Content type: Research article

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  33. Hypoplastic left heart syndrome (HLHS) is a rare but devastating congenital heart defect (CHD) accounting for 25% of all infant deaths due to a CHD. The etiology of HLHS remains elusive, but there is increasin...

    Authors: Andrew Cheng, Whitney Neufeld-Kaiser, Peter H. Byers and Yajuan J. Liu

    Citation: BMC Cardiovascular Disorders 2020 20:137

    Content type: Case report

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  34. The subcutaneous implantable cardioverter defibrillator (S-ICD) is an alternative to the transvenous implantable cardioverter defibrillator for the prevention of sudden cardiac death. Here, we report a rare ca...

    Authors: Yasuhisa Nakao, Kazuyoshi Suenari, Kohei Yamashiro, Hiroshi Nakagawa and Nobuo Shiode

    Citation: BMC Cardiovascular Disorders 2020 20:134

    Content type: Case report

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  35. Left ventricular reverse remodeling (LVRR) has been detected in non-ischemic dilated cardiomyopathy (NIDCM) patients following optimal treatment. However, its prediction with only conventional modalities is of...

    Authors: Togo Iwahana, Sho Okada, Masato Kanda, Motohiko Oshima, Atsushi Iwama, Goro Matsumiya and Yoshio Kobayashi

    Citation: BMC Cardiovascular Disorders 2020 20:116

    Content type: Research article

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  36. Patients with coronary chronic total occlusion (CTO) require effective antiplatelet therapy after percutaneous coronary intervention (PCI). Ticagrelor has more pronounced platelet inhibition than clopidogrel. ...

    Authors: Yong Wang, Hong-wei Zhao, Cheng-fu Wang, Xiao-jiao Zhang, Jie Tao, Chun-sheng Cui, Qing-kun Meng, Yu Zhu, De-feng Luo, Ai-jie Hou and Bo Luan

    Citation: BMC Cardiovascular Disorders 2020 20:109

    Content type: Research article

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  37. In a real-world setting, the effect of pulse rate measured at the time of diagnosis and serially during follow-up and management, on outcomes in heart failure with reduced ejection fraction (HFrEF), has not be...

    Authors: Katherine E. Kurgansky, Petra Schubert, Rachel Parker, Luc Djousse, Jerome B. Riebman, David R. Gagnon and Jacob Joseph

    Citation: BMC Cardiovascular Disorders 2020 20:92

    Content type: Research article

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  38. Gigantic left atrium is defined in the current literature as an excessive dilatation of the left atrium above 65mm. Chronic mitral valve disease is associated with the development of thrombus in the left atriu...

    Authors: Lucia Masarova, Jan Novak, Martin Pesl, Jiri Ondrasek, Jiri Semenka, Eva Simarova and Roman Panovsky

    Citation: BMC Cardiovascular Disorders 2020 20:86

    Content type: Case report

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  39. Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly which has potential for spontaneous rupture into other cardiac chambers or the pericardial space (depending on its location). A ruptured SVA has a ver...

    Authors: Ata Doost, Julie-Ann Craig and Siang Yong Soh

    Citation: BMC Cardiovascular Disorders 2020 20:84

    Content type: Case report

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  40. Tanshinone IIA (TS IIA), a multi-pharmaceutical compound from traditional Chinese herb, is effective for treatment of atherothrombosis. However, the underlying mechanisms of TS IIA-mediated anti-platelet activ...

    Authors: Hua Wang, Lin Zhong, Shaohua Mi, Nianpeng Song, Wei Zhang and Ming Zhong

    Citation: BMC Cardiovascular Disorders 2020 20:81

    Content type: Research article

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  41. Contrast-induced encephalopathy (CIE) is a rare complication of cardiac catheterization; clinical manifestations include cortical blindness, seizures and focal neurological deficits. In general, recurrent epil...

    Authors: Pingping Lei, Weiping He, Quan Shi, Meiying Sun and Zhigang Sun

    Citation: BMC Cardiovascular Disorders 2020 20:79

    Content type: Case report

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  42. Percutaneous closure (LAAC) of the left atrial appendage (LAA) is an efficacious preventive procedure for patients with non-valvular atrial fibrillation (NVAF) and considerable bleeding risk. We sought to syst...

    Authors: Muhammad Ali, Angelos G. Rigopoulos, Mammad Mammadov, Abdelrahman Torky, Andrea Auer, Marios Matiakis, Elena Abate, Constantinos Bakogiannis, Stergios Tzikas, Boris Bigalke, Daniel Sedding and Michel Noutsias

    Citation: BMC Cardiovascular Disorders 2020 20:78

    Content type: Review

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  43. Arrhythmogenic cardiomyopathy (AC) is one of the leading causes for sudden cardiac death (SCD). Recent studies have identified mutations in cardiac desmosomes as key players in the pathogenesis of AC. However,...

    Authors: Xiaoping Lin, Yuankun Ma, Zhejun Cai, Qiyuan Wang, Lihua Wang, Zhaoxia Huo, Dan Hu, Jian’an Wang and Meixiang Xiang

    Citation: BMC Cardiovascular Disorders 2020 20:74

    Content type: Research article

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  44. Cardiac tamponade is a rare but serious complication of Takotsubo cardiomyopathy (TC). Two cases of cardiac tamponade subsequent to TC have been reported. The pericardial effusion in these cases was hemorrhagi...

    Authors: Yuta Nagamori, Takuto Hamaoka, Hisayoshi Murai, Shinichiro Takashima, Takeshi Kato, Soichiro Usui, Kenji Sakata, Hiroshi Furusho, Masaaki Kawashiri and Masayuki Takamura

    Citation: BMC Cardiovascular Disorders 2020 20:67

    Content type: Case report

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  45. Autophagy plays a crucial role in the pathological process of cardiovascular diseases. However, little is known about the pathological mechanism underlying autophagy regulation in dilated cardiomyopathy (DCM).

    Authors: Bo Jin, Haiming Shi, Jun Zhu, Bangwei Wu and Quzhen Geshang

    Citation: BMC Cardiovascular Disorders 2020 20:56

    Content type: Research article

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