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Hypertension and cardiovascular risk

This section concerns all aspects of hypertension and peripheral vascular disease including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology. This section also considers articles concerning patients at high cardiovascular risk, including but not limited to patients with metabolic syndrome and diabetes.

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  1. The meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD).

    Authors: Ai-Fang Feng, Zhong-Hui Liu, Shu-Long Zhou, Shi-Yuan Zhao, Yan-Xin Zhu and Huai-Xin Wang

    Citation: BMC Cardiovascular Disorders 2017 17:174

    Content type: Research article

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  2. Immuno-inflammation plays a major role in the process of hypertension. We aimed to evaluate the association between inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW)...

    Authors: Xiaonan Sun, Leiming Luo, Xiaoqian Zhao, Ping Ye and Ruixue Du

    Citation: BMC Cardiovascular Disorders 2017 17:167

    Content type: Research article

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  3. The benefit of statin on the management of Type 2 Diabetes Mellitus (T2DM) among Chinese patients in primary care is not clear nor fully implemented in clinical practice. This study aimed to evaluate and quant...

    Authors: Colman Siu Cheung Fung, Eric Yuk Fai Wan, Anca Ka Chun Chan and Cindy Lo Kuen Lam

    Citation: BMC Cardiovascular Disorders 2017 17:166

    Content type: Research article

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  4. Atherogenic dyslipidemia is associated with poor cardiovascular outcomes, yet markers of this condition are often ignored in clinical practice. Here, we address a clear evidence gap by assessing the prevalence...

    Authors: Julian P. Halcox, José R. Banegas, Carine Roy, Jean Dallongeville, Guy De Backer, Eliseo Guallar, Joep Perk, David Hajage, Karin M. Henriksson and Claudio Borghi

    Citation: BMC Cardiovascular Disorders 2017 17:160

    Content type: Research article

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  5. Many studies have determined that dehydration is an independent predictor of outcome after ischemic stroke (IS); however, none have determined if the use of thrombolytic therapy modifies the negative impact of...

    Authors: Fei-Fan Wu, Yen-Chu Hung, Y. H. Tsai, Jen-Tsung Yang, Tsong-Hai Lee, Chia-Wei Liow, Jiann-Der Lee, Chung-Jen Lin, Tsung-I Peng and Leng-Chieh Lin

    Citation: BMC Cardiovascular Disorders 2017 17:154

    Content type: Research article

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  6. Diet is an important contributor to risk of cardiovascular disease (CVD) and integral in management and delaying progression. Little is known however about whether increased CVD risk or established CVD has any...

    Authors: Jolene Thomas, Lily Chan, Amanda Wray, Jacqueline Miller, Kaye Mehta, Alison Yaxley, Kacie Dickinson, Louisa Matwiejczyk, Kathryn Jackson and Michelle Miller

    Citation: BMC Cardiovascular Disorders 2017 17:146

    Content type: Research article

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  7. To estimate the prevalence, awareness, treatment and control of arterial hypertension among adult inhabitants of Krasnoyarsk Krai using the data from Russian multicenter epidemiological study ESSE-RF (Epidemio...

    Authors: I. P. Artyukhov, Yu. I. Grinshtein, M. M. Petrova, V. V. Shabalin and R. R. Ruf

    Citation: BMC Cardiovascular Disorders 2017 17:138

    Content type: Research article

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  8. Arterial hypertension is the commonest cause of cardiovascular death. It may lead to hypertensive heart disease (HHD), including heart failure (HF), ischemic heart disease (IHD) and left ventricular hypertroph...

    Authors: Sophie Mavrogeni, Vasiliki Katsi, Vasiliki Vartela, Michel Noutsias, George Markousis-Mavrogenis, Genovefa Kolovou and Athanasios Manolis

    Citation: BMC Cardiovascular Disorders 2017 17:132

    Content type: Review

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  9. Intervention of diabetes care education with regular laboratory check-up in outpatient visits showed long-term benefits to reduce the risk of macrovascular complications among people with type 2 diabetes. Howe...

    Authors: Yun-Ju Lai, Hsiao-Yun Hu, Ya-Ling Lee, Po-Wen Ku, Yung-Feng Yen and Dachen Chu

    Citation: BMC Cardiovascular Disorders 2017 17:130

    Content type: Research article

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  10. About 10–15% patients who take statins experience skeletal muscle problems. Red yeast rice has a good safety profile could provide a compromise therapeutic strategy. Therefore, the aim of this study was to eva...

    Authors: Yangjing Xue, Luyuan Tao, Shaoze Wu, Guoqiang Wang, Lu Qian, Jiwu Li, Lianming Liao, Jifei Tang and Kangting Ji

    Citation: BMC Cardiovascular Disorders 2017 17:127

    Content type: Research article

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  11. Blockers of angiotensin II type 1 receptor (AT1R) and the voltage gated calcium channel 1.2 (CaV1.2) are commonly used for treatment of hypertension. Yet there is little information about the effect of physiologi...

    Authors: Kristoffer Bernhem, Kalaiselvan Krishnan, Alexander Bondar, Hjalmar Brismar, Anita Aperia and Lena Scott

    Citation: BMC Cardiovascular Disorders 2017 17:126

    Content type: Research article

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  12. Carotid-femoral pulse wave velocity (cf-PWV) and aortic PWV measured using MRI (MRI-PWV) show good correlation, but with a significant and consistent bias across studies. The aim of the current study was to ev...

    Authors: Jonathan R Weir-McCall, Faisel Khan, Deirdre B Cassidy, Arsh Thakur, Jennifer Summersgill, Shona Z Matthew, Fiona Adams, Fiona Dove, Stephen J Gandy, Helen M Colhoun, Jill JF Belch and J Graeme Houston

    Citation: BMC Cardiovascular Disorders 2017 17:118

    Content type: Research article

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  13. Although disordered sleep patterns predispose to hypertension (HTN), little is known on the effect of the latter on sleep patterns in sub-Saharan Africa. This study therefore sought to generate preliminary dat...

    Authors: Alfred Kongnyu Njamnshi, Michel Karngong Mengnjo, Eta Ngole Mbong, Samuel Kingue, Julius Yundze Fonsah, Andreas Ateke Njoh, Leonard Njamnshi Nfor, Leonard Ngarka, Samuel Eric Chokote and Felicien Enyime Ntone

    Citation: BMC Cardiovascular Disorders 2017 17:112

    Content type: Research article

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  14. To investigate if percentage change (%∆) in renin over a 3 year follow-up is associated with %∆ in cardiovascular and inflammatory markers in a low renin bi-ethnic group.

    Authors: Rijané Swart, Johannes M. van Rooyen and Catharina M. C. Mels

    Citation: BMC Cardiovascular Disorders 2017 17:104

    Content type: Research article

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  15. Hypertension is a risk factor for peripheral arterial disease (PAD). Subjects with PAD are at increased risk of future cardiovascular (CV) events. Resistin is involved in the pathological processes of CV disea...

    Authors: Bang-Gee Hsu, Chung-Jen Lee, Chiu-Fen Yang, Yu-Chih Chen and Ji-Hung Wang

    Citation: BMC Cardiovascular Disorders 2017 17:80

    Content type: Research article

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  16. Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone...

    Authors: Jon V. Norvik, Henrik Schirmer, Kirsti Ytrehus, Trond G. Jenssen, Svetlana N. Zykova, Anne E. Eggen, Bjørn O. Eriksen and Marit D. Solbu

    Citation: BMC Cardiovascular Disorders 2017 17:79

    Content type: Research article

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  17. Cardiorenal anemia syndrome (CRAS) is an evolving global epidemic associated with increased morbimortality and cost of care. The management of patients with CRAS remains a challenging undertaking worldwide and...

    Authors: Pedro Pallangyo, Francis Fredrick, Smita Bhalia, Paulina Nicholaus, Peter Kisenge, Benjamin Mtinangi, Mohamed Janabi and Stephen Humphrey

    Citation: BMC Cardiovascular Disorders 2017 17:59

    Content type: Research article

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  18. Self-monitoring of hypertension is associated with lower systolic blood pressure (SBP). However, evidence for the use of self-monitoring to titrate antihypertensive medication by physicians is equivocal. Furth...

    Authors: Marloes Franssen, Andrew Farmer, Sabrina Grant, Sheila Greenfield, Carl Heneghan, Richard Hobbs, James Hodgkinson, Susan Jowett, Jonathan Mant, Una Martin, Siobhan Milner, Mark Monahan, Emma Ogburn, Rafael Perera-Salazar, Claire Schwartz, Ly-Mee Yu…

    Citation: BMC Cardiovascular Disorders 2017 17:58

    Content type: Study protocol

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  19. Hypertension is a major risk factor for cardiovascular disease and prevalence varies by ethnic group. The diagnosis and management of blood pressure are informed by guidelines largely based on data from white ...

    Authors: Paramjit Gill, M. Sayeed Haque, Una Martin, Jonathan Mant, Mohammed A. Mohammed, Gurdip Heer, Amanpreet Johal, Ramandeep Kaur, Claire Schwartz, Sally Wood, Sheila M. Greenfield and Richard J. McManus

    Citation: BMC Cardiovascular Disorders 2017 17:55

    Content type: Research article

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  20. Several meta-analyses have indicated that periodontal disease (PD) are related to cardiovascular diseases (CVDs). However, the association between PD and myocardial infarction (MI) remains controversial. Here ...

    Authors: Shuai Xu, Mingbao Song, Yu Xiong, Xi Liu, Yongming He and Zhexue Qin

    Citation: BMC Cardiovascular Disorders 2017 17:50

    Content type: Research article

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  21. Blood pressure (BP) is poorly controlled among a large proportion of hypertensive outpatients. Innovative models of care are therefore needed to improve BP control. The Team-Based Care for improving Hypertensi...

    Authors: Valérie Santschi, Grégoire Wuerzner, Arnaud Chiolero, Bernard Burnand, Philippe Schaller, Lyne Cloutier, Gilles Paradis and Michel Burnier

    Citation: BMC Cardiovascular Disorders 2017 17:39

    Content type: Study protocol

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  22. Patients with peripheral artery disease (PAD) are at increased risk of secondary events, which is exaggerated in the presence of type 2 diabetes mellitus. Diabetes is associated with a systemic pro-inflammator...

    Authors: Sophie J. Bernelot Moens, Robert M. Stoekenbroek, Fleur M. van der Valk, Simone L. Verweij, Mark J. W. Koelemay, Hein J. Verberne, Max Nieuwdorp and Erik S. G. Stroes

    Citation: BMC Cardiovascular Disorders 2016 16:237

    Content type: Research article

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  23. The leading cause of death among firefighters in the United States (U.S.) is cardiovascular events (CVEs) such as sudden cardiac arrest and myocardial infarction. This study compared the cost-effectiveness of ...

    Authors: P. Daniel Patterson, Kenneth J. Smith and David Hostler

    Citation: BMC Cardiovascular Disorders 2016 16:229

    Content type: Research article

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  24. Metabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachial-ankle pulse wave velocity (baPWV). We investigated potential associations between MetS and baPWV in a Chinese co...

    Authors: Anxin Wang, Zhaoping Su, Xiaoxue Liu, Yuling Yang, Shuohua Chen, Suzhen Wang, Yanxia Luo, Xiuhua Guo, Xingquan Zhao and Shouling Wu

    Citation: BMC Cardiovascular Disorders 2016 16:228

    Content type: Research article

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  25. Cardio-metabolic syndrome (CMS) is a highly prevalent condition. There is an urgent need to identify effective and integrated multi-disciplinary approaches that can reduce risk factors for CMS.

    Authors: Ying Zhang, Songli Mei, Rui Yang, Ling Chen, Hang Gao and Li Li

    Citation: BMC Cardiovascular Disorders 2016 16:227

    Content type: Research article

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  26. Metabolism remodeling has been recognized as an early event following cardiac pressure overload. However, its temporal association with ventricular hypertrophy has not been confirmed. Moreover, whether trimeta...

    Authors: Ailan Chen, Wanglin Li, Xinyu Chen, Yuechun Shen, Wenjun Dai, Qi Dong, Xinchun Li, Caiwen Ou and Minsheng Chen

    Citation: BMC Cardiovascular Disorders 2016 16:225

    Content type: Research article

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  27. Many studies showed an association between dietary salt intake, blood pressure and increased CVD risk. The potential reason may be related to vascular structural and functional changes, through alterations in ...

    Authors: Feng Huang, Peng Yu, Yin Yuan, Qiaowei Li, Fan Lin, Zhonghai Gao, Falin Chen and Pengli Zhu

    Citation: BMC Cardiovascular Disorders 2016 16:194

    Content type: Research article

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  28. Treatment of hypertension reduces incidence of stroke, myocardial infarction and heart failure perhaps partly by controlling different metabolic parameters. There is limited information regarding the changes i...

    Authors: Damian J. Damian, Roseanne McNamee and Matthew Carr

    Citation: BMC Cardiovascular Disorders 2016 16:188

    Content type: Research article

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  29. Vascular calcifications such as arteriosclerosis, which is characterized by a calcificiation of the tunica media, represent major comorbidities e.g. in patients with chronic kidney disease (CKD). An essential ste...

    Authors: Christian Freise, Nadja Kretzschmar and Uwe Querfeld

    Citation: BMC Cardiovascular Disorders 2016 16:185

    Content type: Research article

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  30. Activation of the renin-angiotensin-aldosterone-system (RAAS) has been proposed to contribute to development of vascular complications in type 2 diabetes (T2D). The aim of the present study was to determine if...

    Authors: Isabel Gonçalves, Andreas Edsfeldt, Helen M. Colhoun, Angela C. Shore, Carlo Palombo, Andrea Natali, Gunilla Nordin Fredrikson, Harry Björkbacka, Maria Wigren, Eva Bengtsson, Gerd Östling, Kunihiko Aizawa, Francesco Casanova, Margaretha Persson, Kim Gooding, Phil Gates…

    Citation: BMC Cardiovascular Disorders 2016 16:171

    Content type: Research article

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  31. There are well-documented treatment gaps in secondary prevention of coronary heart disease and no clear guidelines to assist early physical activity after acute coronary syndromes (ACS). Smartphone technology ...

    Authors: Matias B. Yudi, David J. Clark, David Tsang, Michael Jelinek, Katie Kalten, Subodh Joshi, Khoa Phan, Arthur Nasis, John Amerena, Sandeep Arunothayaraj, Chris Reid and Omar Farouque

    Citation: BMC Cardiovascular Disorders 2016 16:170

    Content type: Study protocol

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  32. Leg edema is a common adverse effect of dihydropyridine Calcium Channel Blockers (CCB) that may need dose reduction or drug withdrawal, adversely affecting the antihypertensive efficacy. Leg edema is reported ...

    Authors: Priyadarshani Galappatthy, Yasindu C. Waniganayake, Mohomad I. M. Sabeer, Thusitha J. Wijethunga, Gamini K. S. Galappatthy and Ruvan AI Ekanayaka

    Citation: BMC Cardiovascular Disorders 2016 16:168

    Content type: Research article

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  33. Affective temperaments (anxious, depressive, cyclothymic, irritable and hyperthymic) measure subclinical manifestations of major mood disorders. Furthermore, cumulating evidence suggests their involvement in s...

    Authors: Andrea László, Ádám Tabák, Beáta Kőrösi, Dániel Eörsi, Péter Torzsa, Orsolya Cseprekál, András Tislér, György Reusz, Zsófia Nemcsik-Bencze, Xénia Gonda, Zoltán Rihmer and János Nemcsik

    Citation: BMC Cardiovascular Disorders 2016 16:158

    Content type: Research article

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  34. Atrial fibrillation is a major public health problem and is the most common cardiac arrhythmia, affecting an estimated 2.7 million Americans. The true prevalence of atrial fibrillation is likely underestimated...

    Authors: Kathleen T. Hickey, Nicole R. Hauser, Laura E. Valente, Teresa C. Riga, Ashton P. Frulla, Ruth Masterson Creber, William Whang, Hasan Garan, Haomiao Jia, Robert R. Sciacca and Daniel Y. Wang

    Citation: BMC Cardiovascular Disorders 2016 16:152

    Content type: Study protocol

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  35. Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines, act as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cyto...

    Authors: Teresa Auguet, Gemma Aragonès, Esther Guiu-Jurado, Alba Berlanga, Marta Curriu, Salomé Martinez, Ajla Alibalic, Carmen Aguilar, María-Luisa Camara, Esteban Hernández, Xavier Ruyra, Vicente Martín-Paredero and Cristóbal Richart

    Citation: BMC Cardiovascular Disorders 2016 16:149

    Content type: Research article

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  36. Cigarette smoking is known as a major risk factor in the pathogenic mechanisms of stroke, coronary and peripheral artery disease (CAD and PAD), even in young subjects. The aim of this study is the creation of ...

    Authors: Chiara Mozzini, Alder Casadei, Giuseppe Roscia and Luciano Cominacini

    Citation: BMC Cardiovascular Disorders 2016 16:147

    Content type: Research article

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  37. Higher creatine kinase (CK) activity is associated with the development of cardiovascular disease in black African populations. We compared CK activity and investigated associations of blood pressure with CK a...

    Authors: Catharina M. C. Mels, Caitlynd van Zyl and Hugo W. Huisman

    Citation: BMC Cardiovascular Disorders 2016 16:134

    Content type: Research article

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  38. Augmentation index, a marker of central wave reflection, is influenced by age, sex, height, blood pressure, heart rate, and arterial stiffness. However, the detailed haemodynamic determinants of augmentation i...

    Authors: Matias Wilenius, Antti J. Tikkakoski, Anna M. Tahvanainen, Antti Haring, Jenni Koskela, Heini Huhtala, Mika Kähönen, Tiit Kööbi, Jukka T. Mustonen and Ilkka H. Pörsti

    Citation: BMC Cardiovascular Disorders 2016 16:131

    Content type: Research article

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  39. Cardiovascular disease (CVD) is the leading cause of death in Russia. Hypertension and hyperlipidemia are important risk factors for CVD that are modifiable by pharmacological treatment and life-style changes....

    Authors: Marta Cybulsky, Sarah Cook, Anna V. Kontsevaya, Maxim Vasiljev and David A. Leon

    Citation: BMC Cardiovascular Disorders 2016 16:122

    Content type: Research article

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  40. Studies regarding the association between prehypertension and the structual changes of left heart are scanty. However, which type of the geometrical change of left heart is predominated one in prehypertension ...

    Authors: Tan Li, Jun Yang, Xiaofan Guo, Shuang Chen and Yingxian Sun

    Citation: BMC Cardiovascular Disorders 2016 16:114

    Content type: Research article

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  41. Pulse wave velocity (PWV) is a biomarker for arterial stiffness, clinically assessed by applanation tonometry (AT). Increased use of phase-contrast cardiac magnetic resonance (CMR) imaging allows for PWV asses...

    Authors: Karolina Dorniak, Einar Heiberg, Marcin Hellmann, Dorota Rawicz-Zegrzda, Maria Wesierska, Rafal Galaska, Agnieszka Sabisz, Edyta Szurowska, Maria Dudziak and Erik Hedström

    Citation: BMC Cardiovascular Disorders 2016 16:110

    Content type: Research article

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  42. Osteoprotegerin (OPG) and von Willebrand factor (VWF) form complex within endothelial cells and following secretion. The nature of blood group antigens strongly influences the levels of circulating VWF, but th...

    Authors: Elod Erno Nagy, Timea Varga-Fekete, Attila Puskas, Piroska Kelemen, Zoltan Brassai, Katalin Szekeres-Csiki, Timea Gombos, Maria Csilla Csanyi and Jolan Harsfalvi

    Citation: BMC Cardiovascular Disorders 2016 16:106

    Content type: Research article

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  43. In a cross-sectional study we examined whether the haemodynamic response to upright posture could be divided into different functional phenotypes, and whether the observed phenotypes were associated with known...

    Authors: Anna M. Tahvanainen, Antti J. Tikkakoski, Jenni K. Koskela, Klaus Nordhausen, Jani M. Viitala, Miia H. Leskinen, Mika A. P. Kähönen, Tiit Kööbi, Marko T. Uitto, Jari Viik, Jukka T. Mustonen and Ilkka H. Pörsti

    Citation: BMC Cardiovascular Disorders 2016 16:101

    Content type: Research article

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  44. Development of simple instruments for the determination of the level of adherence in patients with high blood pressure is the subject of ongoing research. One such instrument, gaining growing popularity worldw...

    Authors: Izabella Uchmanowicz, Beata Jankowska-Polańska, Anna Chudiak, Anna Szymańska-Chabowska and Grzegorz Mazur

    Citation: BMC Cardiovascular Disorders 2016 16:87

    Content type: Research article

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  45. Patients with rheumatoid arthritis (RA) have an increased risk for cardiovascular disease (CVD) with poor parasympathetic function being implicated as an underlying factor. Factors related to parasympathetic f...

    Authors: Ahmad Osailan, George S. Metsios, Peter C. Rouse, Nikos Ntoumanis, Joan L. Duda, George D. Kitas and Jet J. C. S. Veldhuijzen van Zanten

    Citation: BMC Cardiovascular Disorders 2016 16:86

    Content type: Research article

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  46. Elevated uric acid (UA) is associated with the presence of the metabolic syndrome (MetS). In a prospective cohort study, we assessed whether baseline and longitudinal change in UA were risk factors for develop...

    Authors: Jon V. Norvik, Hilde M. Storhaug, Kirsti Ytrehus, Trond G. Jenssen, Svetlana N. Zykova, Bjørn O. Eriksen and Marit D. Solbu

    Citation: BMC Cardiovascular Disorders 2016 16:85

    Content type: Research article

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  47. The aim of this work is the investigation of measures of ambulatory brachial and aortic blood pressure and indices of arterial stiffness and aortic wave reflection in Marfan patients.

    Authors: Matthias Hillebrand, Ghazaleh Nouri, Bernhard Hametner, Stephanie Parragh, Jelena Köster, Kai Mortensen, Achim Schwarz, Yskert von Kodolitsch and Siegfried Wassertheurer

    Citation: BMC Cardiovascular Disorders 2016 16:81

    Content type: Research article

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