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Hypertension and cardiovascular risk

Section edited by Christian Ott

This section concerns all aspects of hypertension and peripheral vascular disease including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology. This section also considers articles concerning patients at high cardiovascular risk, including but not limited to patients with metabolic syndrome and diabetes.

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  1. Content type: Research article

    Our previous study showed that metformin regulates the mRNA and protein levels of type 2 small conductance calcium-activated potassium channel (SK2) and type 3 small conductance calcium-activated potassium cha...

    Authors: Chang-He Liu, Na Hua, Xi Fu, Yi-Long Pan, Bin Li and Xiao-Dong Li

    Citation: BMC Cardiovascular Disorders 2018 18:236

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  2. Content type: Research article

    Chest compression is a decisive element of cardio-pulmonary resuscitation (CPR). By applying a mechanical CPR device, compression interruptions can be minimised. We examined the efficiency of manual and device...

    Authors: Dóra Ujvárosy, Veronika Sebestyén, Tamás Pataki, Tamás Ötvös, István Lőrincz, György Paragh and Zoltán Szabó

    Citation: BMC Cardiovascular Disorders 2018 18:227

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  3. Content type: Research article

    Lecithin-cholesterol acyltransferase (LCAT) is believed to be involved in reverse cholesterol transport, which is known to play a key role in suppression of atherosclerosis. However, recent investigations have...

    Authors: Katsuaki Yokoyama, Shigemasa Tani, Rei Matsuo and Naoya Matsumoto

    Citation: BMC Cardiovascular Disorders 2018 18:224

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  4. Content type: Research article

    Matrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patien...

    Authors: Tan Li, Jing-Jing Jing, Jun Yang, Li-Ping Sun, Yue-Hua Gong, Shi-Jie Xin and Yuan Yuan

    Citation: BMC Cardiovascular Disorders 2018 18:219

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  5. Content type: Research article

    Sclerostin is known to be a canonical Wnt/β-catenin signaling pathway inhibitor, while the Wnt/β-catenin signaling pathway is proposed to be involved in the development of arterial stiffness. This study aims t...

    Authors: Yu-Chi Chang, Bang-Gee Hsu, Hung-Hsiang Liou, Chung-Jen Lee and Ji-Hung Wang

    Citation: BMC Cardiovascular Disorders 2018 18:214

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  6. Content type: Study protocol

    Hypertension prevalence in young adults has increased and is associated with increased incidence of cerebrovascular and cardiovascular events in middle age. However, there is significant debate regards how to ...

    Authors: Wilby Williamson, Odaro J. Huckstep, Eleni Frangou, Afifah Mohamed, Cheryl Tan, Maryam Alsharqi, Mariane Bertagnolli, Winok Lapidaire, Julia Newton, Henner Hanssen, Richard McManus, Helen Dawes, Charlie Foster, Adam J. Lewandowski and Paul Leeson

    Citation: BMC Cardiovascular Disorders 2018 18:208

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  7. Content type: Research article

    It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a gro...

    Authors: Alina S. Kerimkulova, Olga S. Lunegova, Aibek E. Mirrakhimov, Saamay S. Abilova, Malik P. Nabiev, Ksenia V. Neronova, Erkaiym E. Bektasheva, Ulan M. Toktomamatov, Jyldyz E. Esenbekova and Erkin M. Mirrakhimov

    Citation: BMC Cardiovascular Disorders 2018 18:199

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  8. Content type: Research article

    Treatment adherence play important roles in blood pressure control leading to reduction in morbidity and mortality. This study therefore assessed adherence to pharmacological and non-pharmacological therapies ...

    Authors: Rasaq Adisa, Olumide Ayodeji Ilesanmi and Titilayo Oyelola Fakeye

    Citation: BMC Cardiovascular Disorders 2018 18:194

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  9. Content type: Research article

    Ideal cardiovascular health (CVH) metrics have been found to be associated with subclinical vascular abnormalities. However, the relationship between ideal CVH metrics and retinal vessel calibers and retinal n...

    Authors: Qian Zhang, Dandan Wang, Anxin Wang, Shufeng Zhang, Yuesong Pan, Yang Li, Shengyun Chen, Shouling Wu, Wenbin Wei and Xingquan Zhao

    Citation: BMC Cardiovascular Disorders 2018 18:187

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  10. Content type: Research article

    Despite the epidemiological evidence about the relationship between diabetes, mortality and cardiovascular disease, information about the population impact of uncontrolled diabetes is scarce. We aimed to estim...

    Authors: Jorge Navarro-Pérez, Domingo Orozco-Beltran, Vicente Gil-Guillen, Vicente Pallares, Francisco Valls, Antonio Fernandez, Ana María Perez-Navarro, Carlos Sanchis, Alejandro Dominguez-Lucas, Jose M. Martin-Moreno, Josep Redon and Maria Tellez-Plaza

    Citation: BMC Cardiovascular Disorders 2018 18:180

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  11. Content type: Research article

    Hypertensive crises are clinical syndromes grouped as hypertensive urgency and emergency, which occur as complications of untreated or inadequately treated hypertension. Emergency departments across the world ...

    Authors: Patrick J. Shao, Hendry R. Sawe, Brittany L. Murray, Juma A. Mfinanga, Victor Mwafongo and Michael S. Runyon

    Citation: BMC Cardiovascular Disorders 2018 18:158

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  12. Content type: Research article

    Hypertension is a challenging public health problem with a huge burden in the developing countries. Non-adherence to antihypertensive treatment is a big obstacle in blood pressure (BP) control and favours dise...

    Authors: Nkengla Menka Adidja, Valirie Ndip Agbor, Jeannine A. Aminde, Calypse A. Ngwasiri, Kathleen Blackett Ngu and Leopold Ndemnge Aminde

    Citation: BMC Cardiovascular Disorders 2018 18:150

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  13. Content type: Research article

    The cardiovascular disease risk was assessed in metabolically healthy obese (MHO) children, obese children with metabolic disorders (MUO), and to a control group of normal-weight children using carotid intima-...

    Authors: Giovanni Farello, Annarita Antenucci, Stefano Stagi, Chiara Mazzocchetti, Franco Ciocca and Alberto Verrotti

    Citation: BMC Cardiovascular Disorders 2018 18:140

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  14. Content type: Research article

    To explore the effects of chronic intermittent hypoxia (CIH), which mimics sleep apnea syndrome, on the cardiac renin angiotensin system (RAS), and to investigate the cardiac protection of an angiotensin recep...

    Authors: Wanyu Wang, Ailing Song, Yiming Zeng, Xiaoyang Chen, Yixiang Zhang, Yonghong Shi, Yihua Lin and Wen Luo

    Citation: BMC Cardiovascular Disorders 2018 18:133

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  15. Content type: Research article

    Evidences suggest that central hemodynamics indexes are independent predictors of future cardiovascular events and all-cause mortality. Multiple factors have been pointed to have potential influence on central...

    Authors: Valeria Aparecida Costa-Hong, Henrique Cotchi Simbo Muela, Thiago Andrade Macedo, Allan Robson Kluser Sales and Luiz Aparecido Bortolotto

    Citation: BMC Cardiovascular Disorders 2018 18:123

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  16. Content type: Research article

    The skeletal muscle mass-to-visceral fat area ratio (SVR) has been linked to arterial stiffness in non-diabetic adults. We examined the association between the SVR and arterial stiffness in patients with type ...

    Authors: Jing Xu, Xiaoyan Pan, Haili Liang, Yi Lin, Yilian Hong, Qiya Si, Feixia Shen and Xuejiang Gu

    Citation: BMC Cardiovascular Disorders 2018 18:89

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  17. Content type: Research article

    Increased arterial stiffness (iAS) and microalbuminuria (MAU), which may occur simultaneously or separately in the general population and share similar risk factors, are markers of macro- and microvascular inj...

    Authors: Rujia Miao, Liuxin Wu, Ping Ni, Yue Zeng and Zhiheng Chen

    Citation: BMC Cardiovascular Disorders 2018 18:83

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  18. Content type: Research article

    To compare the reproducibility in total cholesterol (TC), systolic blood pressure (BP), and the resulting Systematic COronary Risk Evaluation (SCORE) obtained by an in-office cardio-preventive screening progra...

    Authors: Sabina Ulbricht, Stefan Gross, Eva Brammen, Franziska Weymar, Ulrich John, Christian Meyer and Marcus Dörr

    Citation: BMC Cardiovascular Disorders 2018 18:84

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  19. Content type: Research article

    Due to a relative lack of outpatient heart failure (HF) clinical registries, we aimed to describe symptoms, signs, and medication treatment among ambulatory patients with heart failure (HF) over time.

    Authors: Larry A. Allen, Fengming Tang, Philip Jones, Tracie Breeding, Angelo Ponirakis and Stuart J. Turner

    Citation: BMC Cardiovascular Disorders 2018 18:80

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  20. Content type: Research article

    The benefits of supervised physical activity programs in cardiac rehabilitation have been amply demonstrated, but the quantity of physical activity often declines quickly once supervision ends. This trial asse...

    Authors: Marion Fournier, Rémi Radel, Laurent Bailly, Christian Pradier, Roxane Fabre, Alain Fuch, Philippe Mossé, Jean-Jacques Domerego, Jocelyn Gal and Fabienne d’Arripe-Longueville

    Citation: BMC Cardiovascular Disorders 2018 18:77

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  21. Content type: Research article

    Centenarians refer to a special group who have outlived most of their fellows. Body shape and abdominal obesity have been identified as cardiovascular disease (CVD) risk factors. Our study aimed to evaluate th...

    Authors: Qiao Zhu, Xiao-Bing Wang, Yao Yao, Chao-Xue Ning, Xiao-Ping Chen, Fu-Xin Luan and Ya-Li Zhao

    Citation: BMC Cardiovascular Disorders 2018 18:73

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  22. Content type: Research article

    The present study sought to explore the relationship of common cardiovascular disease risk factors and noncoding RNAs with essential hypertension (EH).

    Authors: Shiying Chen, Rong Chen, Tingxing Zhang, Shaowei Lin, Zhou Chen, Bi Zhao, Huangyuan Li and Siying Wu

    Citation: BMC Cardiovascular Disorders 2018 18:58

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  23. Content type: Research article

    High salt intake increases blood pressure (BP) and hypertension risk. This study aimed to examine association of urinary sodium excretion with BP and hypertension correlates among Cameroonian pygmies under hun...

    Authors: Daniel Lemogoum, William Ngatchou, Claude Bika Lele, Cecile Okalla, Marc Leeman, Jean-Paul Degaute and Philippe van de Borne

    Citation: BMC Cardiovascular Disorders 2018 18:49

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  24. Content type: Research article

    Antioxidants have shown great promise in stroke prevention. Diarylheptanoids (also known as diphenylheptanoids) are a small class of plant secondary metabolites that possess antioxidant activity greater than t...

    Authors: Cong Lan, Xinjian Chen, Yuxun Zhang, Wei Wang, Wei Eric Wang, Yukai Liu, Yue Cai, Hongmei Ren, Shuo Zheng, Lin Zhou and Chunyu Zeng

    Citation: BMC Cardiovascular Disorders 2018 18:43

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  25. Content type: Research article

    Epicardial adipose tissue (EAT) is an emerging cardio-metabolic risk factor and has been shown to correlate with adverse cardiovascular (CV) outcome; however the underlying pathophysiology of this link is not ...

    Authors: Shaween Al-Talabany, Ify Mordi, J. Graeme Houston, Helen M. Colhoun, Jonathan R. Weir-McCall, Shona Z. Matthew, Helen C. Looker, Daniel Levin, Jill J. F. Belch, Fiona Dove, Faisel Khan and Chim C. Lang

    Citation: BMC Cardiovascular Disorders 2018 18:31

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  26. Content type: Research article

    Inconsistent conclusions have been reported for the genetic relationship between CYP4F2 (Cytochrome P450 Family 4 Subfamily F Member 2) polymorphisms and the susceptibility to cardiovascular and cerebrovascular d...

    Authors: Tao Zhang, Kuiying Yu and Xuhua Li

    Citation: BMC Cardiovascular Disorders 2018 18:29

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  27. Content type: Research article

    Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive...

    Authors: Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d’Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein and Guilherme Gomes Dias Campos

    Citation: BMC Cardiovascular Disorders 2018 18:24

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  28. Content type: Research article

    The rate of blood pressure (BP) control in adult hypertensive patients is poor and the reasons for poor control of BP pressure are not fully understood globally. This study aimed to assess the rate and factors...

    Authors: Saeed M. Omar, Osama Elnour, Gamal K. Adam, Osman E. Osman and Ishag Adam

    Citation: BMC Cardiovascular Disorders 2018 18:26

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  29. Content type: Debate

    National estimates of ‘heart age’ by government health organisations in the US, UK and China show most people have an older heart age than current age. While most heart age calculators are promoted as a commun...

    Authors: Carissa Bonner, Katy Bell, Jesse Jansen, Paul Glasziou, Les Irwig, Jenny Doust and Kirsten McCaffery

    Citation: BMC Cardiovascular Disorders 2018 18:19

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  30. Content type: Research article

    Heart rate (HR) is a prognostic marker that is increasingly used as a therapeutic target in patients with cardiovascular disease. The association between resting and mean HR remains unclear. We therefore set o...

    Authors: Marlena V. Habal, Kumaraswamy Nanthakumar, Peter C. Austin, Cassandra Freitas, Christopher Labos and Douglas S. Lee

    Citation: BMC Cardiovascular Disorders 2018 18:17

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  31. Content type: Research article

    Hypertrophic cardiomyopathy (HCM) is a genetic disease was characterised by left ventricular hypertrophy (LVH), myocardial fibrosis, fiber disarray. The short-axis systolic function is important in left ventri...

    Authors: Jun Huang, Zi-Ning Yan, Yi-Fei Rui, Li Fan, Chang Liu and Jie Li

    Citation: BMC Cardiovascular Disorders 2018 18:13

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  32. Content type: Research article

    The diagnosis of hypertension in children is complex because based on normative values by sex, age and height, and these values vary depending on the environment. Available BP references used, because of the a...

    Authors: Emmanuel Kiyana Muyumba, Dophra Ngoy Nkulu, Clarence Kaut Mukeng, Jacques Mbaz Musung, Placide Kambola Kakoma, Christian Ngama Kakisingi, Oscar Numbi Luboya, Françoise Kaj Malonga, Justin Kalungwe Kizonde, Olivier Mukuku and Weili Yan

    Citation: BMC Cardiovascular Disorders 2018 18:9

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  33. Content type: Research article

    Microvascular rarefaction influences peripheral vascular resistance, perfusion and metabolism by affecting blood pressure and flow pattern. In hypertension microvascular rarefaction has been described in exper...

    Authors: Agnes J. Bosch, Joanna M. Harazny, Iris Kistner, Stefanie Friedrich, Joanna Wojtkiewicz and Roland E. Schmieder

    Citation: BMC Cardiovascular Disorders 2017 17:300

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  34. Content type: Research article

    To evaluate association of 24 h–systolic blood pressure (SBP) variability and obstructive sleep apnea (OSA) as defined by the apnea-hypopnea index ≥5/h; and association of 24 h–SBP variability and prevalent ca...

    Authors: Xiao Ke, Yan Sun, Rongfeng Yang, Jiawen Liang, Shaoyun Wu, Chengheng Hu and Xing Wang

    Citation: BMC Cardiovascular Disorders 2017 17:287

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  35. Content type: Research article

    The purpose of this study was to assess the functional effects and acceptability of rocker-soled shoes that were designed to relatively “unload” the calf muscles during walking in people with calf claudication...

    Authors: Garry A. Tew, Ahmed Shalan, Alastair R. Jordan, Liz Cook, Elizabeth S. Coleman, Caroline Fairhurst, Catherine Hewitt, Stephen W. Hutchins and Andrew Thompson

    Citation: BMC Cardiovascular Disorders 2017 17:283

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  36. Content type: Research article

    Ideal cardiovascular health (CVH) is related to a low cardiovascular disease risk profile. This study aimed to investigate CVH metrics with both the biomarkers and markers of subclinical impairments of cardiov...

    Authors: Ya-Qin Wang, Chang-Fa Wang, Ling Zhu, Hong Yuan, Liu-Xin Wu and Zhi-Heng Chen

    Citation: BMC Cardiovascular Disorders 2017 17:269

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  37. Content type: Study protocol

    Of the estimated 10–11 year life expectancy gap between Indigenous (Aboriginal and Torres Strait Islander people) and non-Indigenous Australians, approximately one quarter is attributable to cardiovascular dis...

    Authors: Marc G. W. Rémond, Simon Stewart, Melinda J. Carrington, Thomas H. Marwick, Bronwyn A. Kingwell, Peter Meikle, Darren O’Brien, Nathaniel S. Marshall and Graeme P. Maguire

    Citation: BMC Cardiovascular Disorders 2017 17:228

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  38. Content type: Research article

    The effects on cardiovascular disease (CVD) by treatment recommendations on prevention of atherosclerotic CVD remain to be evaluated. The objectives were to assess treatment gap for low density lipoprotein cho...

    Authors: Gunilla Journath, Kristina Hambraeus, Emil Hagström, Billie Pettersson and Mickael Löthgren

    Citation: BMC Cardiovascular Disorders 2017 17:224

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  39. Content type: Research article

    Data regarding the prevalence of metabolic syndrome (MetS) among hypertensive patients in Ethiopia is very scarce, and the nature and the burden of MetS among these patients has not been well investigated. The...

    Authors: Agete Tadewos, Tariku Egeno and Antenah Amsalu

    Citation: BMC Cardiovascular Disorders 2017 17:218

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  40. Content type: Research article

    Electrocardiogram (ECG) is commonly used clinically due to convenience, but its accuracy is insufficient for left ventricular hypertrophy (LVH) diagnosis. In this study, we attempted to improve diagnostic accu...

    Authors: Nan Lu, Jin-Xiu Zhu, Pei-Xuan Yang and Xue-Rui Tan

    Citation: BMC Cardiovascular Disorders 2017 17:217

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  41. Content type: Case report

    Takayasu arteritis is a rare, chronic large vessel vasculitis involving the aorta and its primary branches. As the disease progresses, the active inflammation of large vessels leads to dilation, narrowing and ...

    Authors: H. M. M. T. B. Herath, S. P. Pahalagamage, D. Withana and Sunethra Senanayake

    Citation: BMC Cardiovascular Disorders 2017 17:201

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  42. Content type: Research article

    Despite the increased risk for pulmonary hypertension in children with Down syndrome, the response to treatment with targeted therapies for pulmonary hypertension in these patients is not well characterized. The

    Authors: Maurice Beghetti, Andrzej Rudzinski and Min Zhang

    Citation: BMC Cardiovascular Disorders 2017 17:177

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  43. Content type: Research article

    The meta-analysis was aimed to evaluate the effects of AMPD1 gene C34T polymorphism on cardiac function indexes, blood pressure and prognosis in patients with cardiovascular diseases (CVD).

    Authors: Ai-Fang Feng, Zhong-Hui Liu, Shu-Long Zhou, Shi-Yuan Zhao, Yan-Xin Zhu and Huai-Xin Wang

    Citation: BMC Cardiovascular Disorders 2017 17:174

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  44. Content type: Research article

    Immuno-inflammation plays a major role in the process of hypertension. We aimed to evaluate the association between inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), red cell distribution width (RDW)...

    Authors: Xiaonan Sun, Leiming Luo, Xiaoqian Zhao, Ping Ye and Ruixue Du

    Citation: BMC Cardiovascular Disorders 2017 17:167

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  45. Content type: Research article

    The benefit of statin on the management of Type 2 Diabetes Mellitus (T2DM) among Chinese patients in primary care is not clear nor fully implemented in clinical practice. This study aimed to evaluate and quant...

    Authors: Colman Siu Cheung Fung, Eric Yuk Fai Wan, Anca Ka Chun Chan and Cindy Lo Kuen Lam

    Citation: BMC Cardiovascular Disorders 2017 17:166

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  46. Content type: Research article

    Atherogenic dyslipidemia is associated with poor cardiovascular outcomes, yet markers of this condition are often ignored in clinical practice. Here, we address a clear evidence gap by assessing the prevalence...

    Authors: Julian P. Halcox, José R. Banegas, Carine Roy, Jean Dallongeville, Guy De Backer, Eliseo Guallar, Joep Perk, David Hajage, Karin M. Henriksson and Claudio Borghi

    Citation: BMC Cardiovascular Disorders 2017 17:160

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  47. Content type: Research article

    Many studies have determined that dehydration is an independent predictor of outcome after ischemic stroke (IS); however, none have determined if the use of thrombolytic therapy modifies the negative impact of...

    Authors: Fei-Fan Wu, Yen-Chu Hung, Y. H. Tsai, Jen-Tsung Yang, Tsong-Hai Lee, Chia-Wei Liow, Jiann-Der Lee, Chung-Jen Lin, Tsung-I Peng and Leng-Chieh Lin

    Citation: BMC Cardiovascular Disorders 2017 17:154

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  48. Content type: Research article

    Diet is an important contributor to risk of cardiovascular disease (CVD) and integral in management and delaying progression. Little is known however about whether increased CVD risk or established CVD has any...

    Authors: Jolene Thomas, Lily Chan, Amanda Wray, Jacqueline Miller, Kaye Mehta, Alison Yaxley, Kacie Dickinson, Louisa Matwiejczyk, Kathryn Jackson and Michelle Miller

    Citation: BMC Cardiovascular Disorders 2017 17:146

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