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Hypertension and cardiovascular risk

This section concerns all aspects of hypertension and peripheral vascular disease including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology. This section also considers articles concerning patients at high cardiovascular risk, including but not limited to patients with metabolic syndrome and diabetes.

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  1. Content type: Research article

    Remote ischemic conditioning (RIC) is a procedure applied in a limb for triggering endogenous protective pathways in distant organs, namely brain or heart. The underlying mechanisms of RIC are still not fully ...

    Authors: Daniel Noronha Osório, Ricardo Viana-Soares, João Pedro Marto, Marcelo D. Mendonça, Hugo P. Silva, Cláudia Quaresma, Miguel Viana-Baptista, Hugo Gamboa and Helena L. A. Vieira

    Citation: BMC Cardiovascular Disorders 2019 19:211

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  2. Content type: Research article

    Little was known about the different predictive power of blood pressure (BP) parameters (SBP, systolic BP; mean arterial pressure, MAP; pulse pressure, PP; and diastolic BP, DBP) and stroke incidence. This stu...

    Authors: Jia Zheng, Zhaoqing Sun, Xiaofan Guo, Yanxia Xie, Yingxian Sun and Liqiang Zheng

    Citation: BMC Cardiovascular Disorders 2019 19:206

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  3. Content type: Research article

    Premature infants may present with damage to the autonomic nervous system (ANS), which may be related to poorer neurological development. Among the techniques used to evaluate the ANS, heart rate variability (...

    Authors: Luiz Fernando Martins de Souza Filho, Jordana Campos Martins de Oliveira, Mayara Kelly Alves Ribeiro, Marcelo Cozac Moura, Nelson David Fernandes, Rafael Dias de Sousa, Gustavo Rodrigues Pedrino and Ana Cristina Silva Rebelo

    Citation: BMC Cardiovascular Disorders 2019 19:198

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  4. Content type: Research article

    Development of instruments capable of detecting early stage vascular disease has increased interest in employing arterial stiffness (e.g. pulse wave velocity (PWV), augmentation index (AIx)) and endothelial dy...

    Authors: Raissa Perrault, Alexander Omelchenko, Carla G. Taylor and Peter Zahradka

    Citation: BMC Cardiovascular Disorders 2019 19:190

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  5. Content type: Research article

    The patient self-management (PSM) is an effective approach for controlling the international normalized ratio, INR, within the therapeutic range. Nevertheless, most of the literature derives from randomized cl...

    Authors: Bárbara Menéndez-Jándula, José Antonio García-Erce, Clara Zazo and Luis Larrad-Mur

    Citation: BMC Cardiovascular Disorders 2019 19:186

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  6. Content type: Case report

    Atrial fibrillation (AF) significantly increases the risk of ischemic stroke depending on various risk factors. The CHA2DS2-VASc score is used widely to improve stratification of AF-related stroke to identify for...

    Authors: Chen-Di Cheng, Xiang Gu, Hong-Xiao Li, Ruo-Yu Duan, Lei Sun, Yi Zhang, Zheng-Yu Bao, Jian-Hua Shen, Fu-Kun Chen and Ye Zhu

    Citation: BMC Cardiovascular Disorders 2019 19:178

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  7. Content type: Research article

    With aging of the population, screening and prevention health programs for blood donors will increasingly be a priority. We aimed at: assessing the 10 year-cardiovascular disease (CVD) risk in blood donors, ac...

    Authors: Francesco Vadini, Francesca Santilli, Giuseppe Casalini, Mario dell’Isola, Ornella Iuliani, Damiano D’Ardes, Luisa Lattanzio, Marta Di Nicola, Giancarlo Di Iorio and Patrizia Accorsi

    Citation: BMC Cardiovascular Disorders 2019 19:177

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  8. Content type: Research article

    An estimated 55% of older adults in Africa have systemic hypertension, a major risk factor for stroke, heart failure and dementia in the region. The risk factors associated with hypertension in this population...

    Authors: William Kofi Bosu, Justice Moses Kwaku Aheto, Eugenio Zucchelli and Siobhan Theresa Reilly

    Citation: BMC Cardiovascular Disorders 2019 19:173

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  9. Content type: Research article

    Improving clinical practice aimed at controlling hypertension is a pending issue in health systems. One of the methods currently used for this purpose is self blood pressure measurement (SBPM) whose use increa...

    Authors: Arleen De León-Robert, Juan José Gascón-Cánovas, José Joaquín Antón-Botella, Isabel María Hidalgo-García, Carmen López-Alegría, Yoalys Dilvani Pérez-Cabrera and Heidy Merari Campusano-Castellanos

    Citation: BMC Cardiovascular Disorders 2019 19:171

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  10. Content type: Research article

    Microparticles are procoagulant membrane vesicles that play role in endothelium dysfunction pathogenesis and are increased in hypertension, acute/chronic vascular pathological events. Here; we aimed to compare...

    Authors: Hanife Usta Atmaca, Feray Akbas and Hale Aral

    Citation: BMC Cardiovascular Disorders 2019 19:164

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  11. Content type: Research article

    Non-traumatic chest pain (NTCP) is a common reason for emergency department (ED) attendance in high-income countries, with the primary concern focused on life threatening cardiovascular diseases. There is gene...

    Authors: Amour S. Mohamed, Hendry R. Sawe, Biita Muhanuzi, Nafsa R. Marombwa, Kilalo Mjema and Ellen J. Weber

    Citation: BMC Cardiovascular Disorders 2019 19:158

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  12. Content type: Research article

    Genetic and environment play a significant role in the etiology of essential hypertension (EH). Recently STK39 rs3754777, ATP2B1 rs2681472 and rs17249754 have been associated with BP variation and hypertension. I...

    Authors: Herman Karim Sombié, Jonas Koudougou Kologo, Daméhan Tchelougou, Serge Yannick Ouédraogo, Abdoul Karim Ouattara, Tegwindé Rebecca Compaoré, Bolni Marius Nagalo, Abel Pegdwendé Sorgho, Issoufou Nagabila, Serge Théophile Soubeïga, Florencia Wendkuuni Djigma, Albert Théophane Yonli, Patrice Zabsonré, Hassanata Millogo and Jacques Simporé

    Citation: BMC Cardiovascular Disorders 2019 19:155

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  13. Content type: Research article

    We investigated changes of cortical thickness and its association with cognitive performance in patients with high-grade carotid artery stenosis without ischemic brain lesions.

    Authors: Alina Nickel, Simon Kessner, Andreas Niebuhr, Julian Schröder, Caroline Malherbe, Felix Fischer, Marlene Heinze, Bastian Cheng, Jens Fiehler, Hans Pinnschmidt, Axel Larena-Avellaneda, Christian Gerloff and Götz Thomalla

    Citation: BMC Cardiovascular Disorders 2019 19:154

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  14. Content type: Research article

    Fatty acid-binding protein 4 (FABP4) (also known as adipocyte FABP or adipocyte P2) is expressed in adipocytes, macrophages, and capillary endothelial cells. Previous studies have shown associations among plas...

    Authors: Chao-Ping Wang, Chia-Chang Hsu, Wei-Chin Hung, Teng-Hung Yu, Cheng-Ching Wu, I-Ting Tsai, Wei-Hua Tang, Fu-Mei Chung, Jer-Yiing Houng, Yau-Jiunn Lee and Yung-Chuan Lu

    Citation: BMC Cardiovascular Disorders 2019 19:153

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  15. Content type: Research article

    Although invasively measured blood pressure (invBP) is regarded as a “gold standard” in critically ill cardiac patients, the non-invasive BP is still widely used, at least at the initiation of medical care. Th...

    Authors: Jitka Seidlerová, Pavlína Tůmová, Richard Rokyta and Milan Hromadka

    Citation: BMC Cardiovascular Disorders 2019 19:150

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  16. Content type: Research article

    CD36 is associated with regulation of lipid metabolism, atherosclerosis, and blood pressure. Moreover, its variation may be involved in the development of hypertension and/or coronary artery disease (CAD). The...

    Authors: Mohammad Amin Momeni-Moghaddam, Gholamreza Asadikaram, Hamed Akbari, Moslem Abolhassani, Mohammad Masoumi, Zahra Nadimy and Mohammad Khaksari

    Citation: BMC Cardiovascular Disorders 2019 19:140

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  17. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is one of the most prevalent cardiac and cerebrovascular risk factors. The study aimed to find a new way to investigate left ventricle (LV) systolic dysfunction in T2DM patients...

    Authors: Jun Huang, Hai-Ling Hu, Zi-Ning Yan, Li Fan, Yi-Fei Rui, Dan Shen and Jie Li

    Citation: BMC Cardiovascular Disorders 2019 19:137

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  18. Content type: Research article

    Effects of β-blockers on outcomes in patients with chronic heart failure (CHF) and atrial fibrillation (AF) is still in controversy.

    Authors: Tianyu Xu, Yuli Huang, Haobin Zhou, Yujia Bai, Xingfu Huang, Yunzhao Hu, Dingli Xu, Yuhui Zhang and Jian Zhang

    Citation: BMC Cardiovascular Disorders 2019 19:135

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  19. Content type: Research article

    Bone morphogenetic protein9 (BMP9) has been reported to have a role in vascular development. However, there is still a lack of information regarding the association between circulating BMP9 levels and cardiova...

    Authors: Rui Liu, Wenjing Hu, Xiaoqiang Li, Danlan Pu, Gangyi Yang, Hua Liu, Minghong Tan and Danping Zhu

    Citation: BMC Cardiovascular Disorders 2019 19:131

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  20. Content type: Research article

    Despite the availability and improvement in diagnostic and therapeutic interventions with proven benefits in reducing cardiovascular morbidity and mortality, control rates of hypertension remain poor and gross...

    Authors: Gebrewahd Bezabh Gebremichael, Kalayou Kidanu Berhe and Teklewoini Mariye Zemichael

    Citation: BMC Cardiovascular Disorders 2019 19:121

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  21. Content type: Research article

    Previous studies reported that low level of oestradiol (E2) was associated with higher risk of cardiovascular disease (CVD). However, little study examined the relationship between E2 and CVD in longevous wome...

    Authors: Qiao Zhu, Yao Yao, Chao-Xue Ning, Xiao-Ping Chen, Fu-Xin Luan, Liang Liu, Qiong Liu, Na Wang, Fu Zhang and Ya-Li Zhao

    Citation: BMC Cardiovascular Disorders 2019 19:115

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  22. Content type: Research article

    Parathyroidectomy has ameliorated cardiovascular risk factors in patients with hypercalcemic primary hyperparathyroidism (PHPT), but the effect of parathyroidectomy on normocalcemic PHPT is not exactly known. ...

    Authors: Selvihan Beysel, Mustafa Caliskan, Muhammed Kizilgul, Mahmut Apaydin, Seyfullah Kan, Mustafa Ozbek and Erman Cakal

    Citation: BMC Cardiovascular Disorders 2019 19:106

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  23. Content type: Research article

    Left ventricle mass (LVM) can be influenced by various conditions including hypertension and/or inherent cardiomyopathies. Dysglycemia is also thought to exert an anabolic effect on heart tissue by hyperinsuli...

    Authors: Gokulan Pararajasingam, Brian Bridal Løgstrup, Dan Eik Høfsten, Thomas Brøcher Christophersen, Søren Auscher, Jørgen Hangaard and Kenneth Egstrup

    Citation: BMC Cardiovascular Disorders 2019 19:103

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  24. Content type: Research article

    Studies from Saudi Arabia have reported a continued increase in the prevalence of cardiovascular diseases and their associated risk factors. The objective of this study was to measure the gender differences in...

    Authors: AlJohara M. AlQuaiz, Amna Rehana Siddiqui, Ambreen Kazi, Mohammad Ali Batais and Ali M. Al-Hazmi

    Citation: BMC Cardiovascular Disorders 2019 19:88

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  25. Content type: Research article

    Ferritin is one of the key proteins that regulate iron homeostasis and is widely available clinical biomarker of iron status. This study aimed to discuss the influence of serum ferritin (SF) on cardiovascular ...

    Authors: Jun-Ru Liu, Yang Liu, Fu-Zai Yin and Bo-Wei Liu

    Citation: BMC Cardiovascular Disorders 2019 19:82

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  26. Content type: Research article

    Type D personality is associated with unfavorable outcomes in patients with cardiovascular diseases (CVD). However, there is no valid Type D Scale in Russian language. The purpose of the study was to examine t...

    Authors: Georgiy Pushkarev, Johan Denollet, Vadim Kuznetsov, Viola Spek and Elena Yaroslavskaya

    Citation: BMC Cardiovascular Disorders 2019 19:78

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  27. Content type: Research article

    Resistant hypertension and renal sympathetic hyperactivity are closely linked, and catheter-based renal denervation (RDN) is regarded as a new treatment strategy. However, the acute changes in vascular morphol...

    Authors: Enyong Su, Linwei Zhao, Chuanyu Gao, Wen Zhao, Xianpei Wang, Datun Qi, Lijie Zhu, Xiaohang Yang, Binbin Zhu and Yahui Liu

    Citation: BMC Cardiovascular Disorders 2019 19:67

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  28. Content type: Research article

    With development of cholesterol management guidelines by the American College of Cardiology/American Heart Association (ACC/AHA), more individuals at risk of cardiovascular disease may be eligible for statin t...

    Authors: Omar Hamoui, Mohamed I. Omar, Frederick J. Raal, Wafa Rashed, Abdoul Kane, Mohamed Alami, Paula Abreu, Walid Mashhoud and Alawi A. Alsheikh-Ali

    Citation: BMC Cardiovascular Disorders 2019 19:61

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  29. Content type: Research article

    Cardiovascular (CV) disease (CVD) is a well-recognized complication of type 2 diabetes mellitus (T2DM) and there is a clinical need for glucose-lowering therapies that do not further increase CV risk in this p...

    Authors: Marile Santamarina and Curt J. Carlson

    Citation: BMC Cardiovascular Disorders 2019 19:60

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  30. Content type: Research article

    Daily aerobic exercise such as healthy walking could have an immediate effect on parameters of arterial stiffness; however, there is little evidence in the diabetic population. Our aim, therefore, is to evalua...

    Authors: Rosario Alonso-Domínguez, José I. Recio-Rodríguez, Maria C. Patino-Alonso, Natalia Sánchez-Aguadero, Luis García-Ortiz and Manuel A. Gómez-Marcos

    Citation: BMC Cardiovascular Disorders 2019 19:56

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  31. Content type: Research article

    To evaluate the impact of a rapid change in preferred treatment from clopidogrel to ticagrelor on the risk of ischemic stroke following acute myocardial infarction (AMI).

    Authors: Robin Henriksson, Anders Ulvenstam, Lars Söderström and Thomas Mooe

    Citation: BMC Cardiovascular Disorders 2019 19:51

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  32. Content type: Study protocol

    To increase cardiovascular disease prevention efforts, worksite interventions can promote healthy food choices, facilitate health education, increase physical activity and provide social support. This pioneer ...

    Authors: Archana Shrestha, Dipesh Tamrakar, Biraj Man Karmacharya, Abha Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Prajjwal Pyakurel, Polyna Khudyakov, Vasanti Malik, Josiemer Mattei and Donna Spiegelman

    Citation: BMC Cardiovascular Disorders 2019 19:48

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  33. Content type: Research article

    Although the link between elevated uric acid and metabolic syndrome has been reported in some studies; the relationship of serum uric acid (SUA) with lipid profile has not well studied or little is known so fa...

    Authors: Nurshad Ali, Sadaqur Rahman, Shiful Islam, Tangigul Haque, Noyan Hossain Molla, Abu Hasan Sumon, Rahanuma Raihanu Kathak, Md Asaduzzaman, Farjana Islam, Nayan Chandra Mohanto, Mohammad Abul Hasnat, Shaikh Mirja Nurunnabi and Shamim Ahmed

    Citation: BMC Cardiovascular Disorders 2019 19:42

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  34. Content type: Research article

    Protein arginine methyltransferases (PRMTs) can catalyse the methylation of arginine and participate in many important cellular reaction processes. The purpose of this research is to determine whether the expr...

    Authors: Buchuan Tan, Qian Liu, Liping Yang, Yushuang Yang, Dongna Liu, Long Liu and Fanbo Meng

    Citation: BMC Cardiovascular Disorders 2019 19:31

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  35. Content type: Research article

    To determine the prevalence of hypertension treatment and control among hypertensive patients in the Cuban municipalities of Cardenas and Santiago and to explore the main associated predictors.

    Authors: Esteban Londoño Agudelo, Armando Rodríguez Salvá, Addys Díaz Piñera, René García Roche, Pol De Vos, Tullia Battaglioli and Patrick Van der Stuyft

    Citation: BMC Cardiovascular Disorders 2019 19:29

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  36. Content type: Research article

    Our objectives were to critically appraise and summarise the current evidence for the effectiveness of using cardiovascular disease (CVD) risk scoring (total risk assessment - TRA) in routine risk assessment i...

    Authors: Krzysztof Studziński, Tomasz Tomasik, Janusz Krzysztoń, Jacek Jóźwiak and Adam Windak

    Citation: BMC Cardiovascular Disorders 2019 19:11

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  37. Content type: Research article

    Previous studies revealed a high rate of abnormal exercise test (ET) results in the absence of obstructive coronary artery disease (CAD) in asymptomatic athletes. The physiological background of this phenomeno...

    Authors: Danny A. J. P. van de Sande, Jan Hoogsteen, Pieter A. Doevendans and Hareld M. C. Kemps

    Citation: BMC Cardiovascular Disorders 2019 19:6

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  38. Content type: Research article

    Most patients with antihypertensive medication do not achieve their blood pressure (BP) target. The most important factor behind this failure is poor medication adherence. However, non-adherence to therapy doe...

    Authors: Aapo Tahkola, Päivi Korhonen, Hannu Kautiainen, Teemu Niiranen and Pekka Mäntyselkä

    Citation: BMC Cardiovascular Disorders 2018 18:240

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  39. Content type: Research article

    Our previous study showed that metformin regulates the mRNA and protein levels of type 2 small conductance calcium-activated potassium channel (SK2) and type 3 small conductance calcium-activated potassium cha...

    Authors: Chang-He Liu, Na Hua, Xi Fu, Yi-Long Pan, Bin Li and Xiao-Dong Li

    Citation: BMC Cardiovascular Disorders 2018 18:236

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  40. Content type: Research article

    Chest compression is a decisive element of cardio-pulmonary resuscitation (CPR). By applying a mechanical CPR device, compression interruptions can be minimised. We examined the efficiency of manual and device...

    Authors: Dóra Ujvárosy, Veronika Sebestyén, Tamás Pataki, Tamás Ötvös, István Lőrincz, György Paragh and Zoltán Szabó

    Citation: BMC Cardiovascular Disorders 2018 18:227

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  41. Content type: Research article

    Lecithin-cholesterol acyltransferase (LCAT) is believed to be involved in reverse cholesterol transport, which is known to play a key role in suppression of atherosclerosis. However, recent investigations have...

    Authors: Katsuaki Yokoyama, Shigemasa Tani, Rei Matsuo and Naoya Matsumoto

    Citation: BMC Cardiovascular Disorders 2018 18:224

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  42. Content type: Research article

    Matrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patien...

    Authors: Tan Li, Jing-Jing Jing, Jun Yang, Li-Ping Sun, Yue-Hua Gong, Shi-Jie Xin and Yuan Yuan

    Citation: BMC Cardiovascular Disorders 2018 18:219

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  43. Content type: Research article

    Sclerostin is known to be a canonical Wnt/β-catenin signaling pathway inhibitor, while the Wnt/β-catenin signaling pathway is proposed to be involved in the development of arterial stiffness. This study aims t...

    Authors: Yu-Chi Chang, Bang-Gee Hsu, Hung-Hsiang Liou, Chung-Jen Lee and Ji-Hung Wang

    Citation: BMC Cardiovascular Disorders 2018 18:214

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  44. Content type: Study protocol

    Hypertension prevalence in young adults has increased and is associated with increased incidence of cerebrovascular and cardiovascular events in middle age. However, there is significant debate regards how to ...

    Authors: Wilby Williamson, Odaro J. Huckstep, Eleni Frangou, Afifah Mohamed, Cheryl Tan, Maryam Alsharqi, Mariane Bertagnolli, Winok Lapidaire, Julia Newton, Henner Hanssen, Richard McManus, Helen Dawes, Charlie Foster, Adam J. Lewandowski and Paul Leeson

    Citation: BMC Cardiovascular Disorders 2018 18:208

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  45. Content type: Research article

    It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a gro...

    Authors: Alina S. Kerimkulova, Olga S. Lunegova, Aibek E. Mirrakhimov, Saamay S. Abilova, Malik P. Nabiev, Ksenia V. Neronova, Erkaiym E. Bektasheva, Ulan M. Toktomamatov, Jyldyz E. Esenbekova and Erkin M. Mirrakhimov

    Citation: BMC Cardiovascular Disorders 2018 18:199

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  46. Content type: Research article

    Treatment adherence play important roles in blood pressure control leading to reduction in morbidity and mortality. This study therefore assessed adherence to pharmacological and non-pharmacological therapies ...

    Authors: Rasaq Adisa, Olumide Ayodeji Ilesanmi and Titilayo Oyelola Fakeye

    Citation: BMC Cardiovascular Disorders 2018 18:194

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  47. Content type: Research article

    Ideal cardiovascular health (CVH) metrics have been found to be associated with subclinical vascular abnormalities. However, the relationship between ideal CVH metrics and retinal vessel calibers and retinal n...

    Authors: Qian Zhang, Dandan Wang, Anxin Wang, Shufeng Zhang, Yuesong Pan, Yang Li, Shengyun Chen, Shouling Wu, Wenbin Wei and Xingquan Zhao

    Citation: BMC Cardiovascular Disorders 2018 18:187

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