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Hypertension and cardiovascular risk

Section edited by Christian Ott

This section concerns all aspects of hypertension and peripheral vascular disease including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology. This section also considers articles concerning patients at high cardiovascular risk, including but not limited to patients with metabolic syndrome and diabetes.

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  1. Content type: Research article

    Resistant hypertension and renal sympathetic hyperactivity are closely linked, and catheter-based renal denervation (RDN) is regarded as a new treatment strategy. However, the acute changes in vascular morphol...

    Authors: Enyong Su, Linwei Zhao, Chuanyu Gao, Wen Zhao, Xianpei Wang, Datun Qi, Lijie Zhu, Xiaohang Yang, Binbin Zhu and Yahui Liu

    Citation: BMC Cardiovascular Disorders 2019 19:67

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  2. Content type: Research article

    With development of cholesterol management guidelines by the American College of Cardiology/American Heart Association (ACC/AHA), more individuals at risk of cardiovascular disease may be eligible for statin t...

    Authors: Omar Hamoui, Mohamed I. Omar, Frederick J. Raal, Wafa Rashed, Abdoul Kane, Mohamed Alami, Paula Abreu, Walid Mashhoud and Alawi A. Alsheikh-Ali

    Citation: BMC Cardiovascular Disorders 2019 19:61

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  3. Content type: Research article

    Cardiovascular (CV) disease (CVD) is a well-recognized complication of type 2 diabetes mellitus (T2DM) and there is a clinical need for glucose-lowering therapies that do not further increase CV risk in this p...

    Authors: Marile Santamarina and Curt J. Carlson

    Citation: BMC Cardiovascular Disorders 2019 19:60

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  4. Content type: Research article

    Daily aerobic exercise such as healthy walking could have an immediate effect on parameters of arterial stiffness; however, there is little evidence in the diabetic population. Our aim, therefore, is to evalua...

    Authors: Rosario Alonso-Domínguez, José I. Recio-Rodríguez, Maria C. Patino-Alonso, Natalia Sánchez-Aguadero, Luis García-Ortiz and Manuel A. Gómez-Marcos

    Citation: BMC Cardiovascular Disorders 2019 19:56

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  5. Content type: Research article

    To evaluate the impact of a rapid change in preferred treatment from clopidogrel to ticagrelor on the risk of ischemic stroke following acute myocardial infarction (AMI).

    Authors: Robin Henriksson, Anders Ulvenstam, Lars Söderström and Thomas Mooe

    Citation: BMC Cardiovascular Disorders 2019 19:51

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  6. Content type: Study protocol

    To increase cardiovascular disease prevention efforts, worksite interventions can promote healthy food choices, facilitate health education, increase physical activity and provide social support. This pioneer ...

    Authors: Archana Shrestha, Dipesh Tamrakar, Biraj Man Karmacharya, Abha Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Prajjwal Pyakurel, Polyna Khudyakov, Vasanti Malik, Josiemer Mattei and Donna Spiegelman

    Citation: BMC Cardiovascular Disorders 2019 19:48

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  7. Content type: Research article

    Although the link between elevated uric acid and metabolic syndrome has been reported in some studies; the relationship of serum uric acid (SUA) with lipid profile has not well studied or little is known so fa...

    Authors: Nurshad Ali, Sadaqur Rahman, Shiful Islam, Tangigul Haque, Noyan Hossain Molla, Abu Hasan Sumon, Rahanuma Raihanu Kathak, Md Asaduzzaman, Farjana Islam, Nayan Chandra Mohanto, Mohammad Abul Hasnat, Shaikh Mirja Nurunnabi and Shamim Ahmed

    Citation: BMC Cardiovascular Disorders 2019 19:42

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  8. Content type: Research article

    Protein arginine methyltransferases (PRMTs) can catalyse the methylation of arginine and participate in many important cellular reaction processes. The purpose of this research is to determine whether the expr...

    Authors: Buchuan Tan, Qian Liu, Liping Yang, Yushuang Yang, Dongna Liu, Long Liu and Fanbo Meng

    Citation: BMC Cardiovascular Disorders 2019 19:31

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  9. Content type: Research article

    To determine the prevalence of hypertension treatment and control among hypertensive patients in the Cuban municipalities of Cardenas and Santiago and to explore the main associated predictors.

    Authors: Esteban Londoño Agudelo, Armando Rodríguez Salvá, Addys Díaz Piñera, René García Roche, Pol De Vos, Tullia Battaglioli and Patrick Van der Stuyft

    Citation: BMC Cardiovascular Disorders 2019 19:29

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  10. Content type: Research article

    Our objectives were to critically appraise and summarise the current evidence for the effectiveness of using cardiovascular disease (CVD) risk scoring (total risk assessment - TRA) in routine risk assessment i...

    Authors: Krzysztof Studziński, Tomasz Tomasik, Janusz Krzysztoń, Jacek Jóźwiak and Adam Windak

    Citation: BMC Cardiovascular Disorders 2019 19:11

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  11. Content type: Research article

    Previous studies revealed a high rate of abnormal exercise test (ET) results in the absence of obstructive coronary artery disease (CAD) in asymptomatic athletes. The physiological background of this phenomeno...

    Authors: Danny A. J. P. van de Sande, Jan Hoogsteen, Pieter A. Doevendans and Hareld M. C. Kemps

    Citation: BMC Cardiovascular Disorders 2019 19:6

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  12. Content type: Research article

    Most patients with antihypertensive medication do not achieve their blood pressure (BP) target. The most important factor behind this failure is poor medication adherence. However, non-adherence to therapy doe...

    Authors: Aapo Tahkola, Päivi Korhonen, Hannu Kautiainen, Teemu Niiranen and Pekka Mäntyselkä

    Citation: BMC Cardiovascular Disorders 2018 18:240

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  13. Content type: Research article

    Our previous study showed that metformin regulates the mRNA and protein levels of type 2 small conductance calcium-activated potassium channel (SK2) and type 3 small conductance calcium-activated potassium cha...

    Authors: Chang-He Liu, Na Hua, Xi Fu, Yi-Long Pan, Bin Li and Xiao-Dong Li

    Citation: BMC Cardiovascular Disorders 2018 18:236

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  14. Content type: Research article

    Chest compression is a decisive element of cardio-pulmonary resuscitation (CPR). By applying a mechanical CPR device, compression interruptions can be minimised. We examined the efficiency of manual and device...

    Authors: Dóra Ujvárosy, Veronika Sebestyén, Tamás Pataki, Tamás Ötvös, István Lőrincz, György Paragh and Zoltán Szabó

    Citation: BMC Cardiovascular Disorders 2018 18:227

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  15. Content type: Research article

    Lecithin-cholesterol acyltransferase (LCAT) is believed to be involved in reverse cholesterol transport, which is known to play a key role in suppression of atherosclerosis. However, recent investigations have...

    Authors: Katsuaki Yokoyama, Shigemasa Tani, Rei Matsuo and Naoya Matsumoto

    Citation: BMC Cardiovascular Disorders 2018 18:224

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  16. Content type: Research article

    Matrix metalloproteinase 9 (MMP9) and Toll-like receptor 4 (TLR4) play important roles in aortic pathophysiology. However, there is lacking research on serum TLR4 levels in acute aortic dissection (AAD) patien...

    Authors: Tan Li, Jing-Jing Jing, Jun Yang, Li-Ping Sun, Yue-Hua Gong, Shi-Jie Xin and Yuan Yuan

    Citation: BMC Cardiovascular Disorders 2018 18:219

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  17. Content type: Research article

    Sclerostin is known to be a canonical Wnt/β-catenin signaling pathway inhibitor, while the Wnt/β-catenin signaling pathway is proposed to be involved in the development of arterial stiffness. This study aims t...

    Authors: Yu-Chi Chang, Bang-Gee Hsu, Hung-Hsiang Liou, Chung-Jen Lee and Ji-Hung Wang

    Citation: BMC Cardiovascular Disorders 2018 18:214

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  18. Content type: Study protocol

    Hypertension prevalence in young adults has increased and is associated with increased incidence of cerebrovascular and cardiovascular events in middle age. However, there is significant debate regards how to ...

    Authors: Wilby Williamson, Odaro J. Huckstep, Eleni Frangou, Afifah Mohamed, Cheryl Tan, Maryam Alsharqi, Mariane Bertagnolli, Winok Lapidaire, Julia Newton, Henner Hanssen, Richard McManus, Helen Dawes, Charlie Foster, Adam J. Lewandowski and Paul Leeson

    Citation: BMC Cardiovascular Disorders 2018 18:208

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  19. Content type: Research article

    It is known that atherosclerosis is the leading cause of cardiovascular disease. We aimed to study the correlation between components of metabolic syndrome (MS) and subclinical carotid atherosclerosis in a gro...

    Authors: Alina S. Kerimkulova, Olga S. Lunegova, Aibek E. Mirrakhimov, Saamay S. Abilova, Malik P. Nabiev, Ksenia V. Neronova, Erkaiym E. Bektasheva, Ulan M. Toktomamatov, Jyldyz E. Esenbekova and Erkin M. Mirrakhimov

    Citation: BMC Cardiovascular Disorders 2018 18:199

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  20. Content type: Research article

    Treatment adherence play important roles in blood pressure control leading to reduction in morbidity and mortality. This study therefore assessed adherence to pharmacological and non-pharmacological therapies ...

    Authors: Rasaq Adisa, Olumide Ayodeji Ilesanmi and Titilayo Oyelola Fakeye

    Citation: BMC Cardiovascular Disorders 2018 18:194

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  21. Content type: Research article

    Ideal cardiovascular health (CVH) metrics have been found to be associated with subclinical vascular abnormalities. However, the relationship between ideal CVH metrics and retinal vessel calibers and retinal n...

    Authors: Qian Zhang, Dandan Wang, Anxin Wang, Shufeng Zhang, Yuesong Pan, Yang Li, Shengyun Chen, Shouling Wu, Wenbin Wei and Xingquan Zhao

    Citation: BMC Cardiovascular Disorders 2018 18:187

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  22. Content type: Research article

    Despite the epidemiological evidence about the relationship between diabetes, mortality and cardiovascular disease, information about the population impact of uncontrolled diabetes is scarce. We aimed to estim...

    Authors: Jorge Navarro-Pérez, Domingo Orozco-Beltran, Vicente Gil-Guillen, Vicente Pallares, Francisco Valls, Antonio Fernandez, Ana María Perez-Navarro, Carlos Sanchis, Alejandro Dominguez-Lucas, Jose M. Martin-Moreno, Josep Redon and Maria Tellez-Plaza

    Citation: BMC Cardiovascular Disorders 2018 18:180

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  23. Content type: Research article

    Hypertensive crises are clinical syndromes grouped as hypertensive urgency and emergency, which occur as complications of untreated or inadequately treated hypertension. Emergency departments across the world ...

    Authors: Patrick J. Shao, Hendry R. Sawe, Brittany L. Murray, Juma A. Mfinanga, Victor Mwafongo and Michael S. Runyon

    Citation: BMC Cardiovascular Disorders 2018 18:158

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  24. Content type: Research article

    Hypertension is a challenging public health problem with a huge burden in the developing countries. Non-adherence to antihypertensive treatment is a big obstacle in blood pressure (BP) control and favours dise...

    Authors: Nkengla Menka Adidja, Valirie Ndip Agbor, Jeannine A. Aminde, Calypse A. Ngwasiri, Kathleen Blackett Ngu and Leopold Ndemnge Aminde

    Citation: BMC Cardiovascular Disorders 2018 18:150

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  25. Content type: Research article

    The cardiovascular disease risk was assessed in metabolically healthy obese (MHO) children, obese children with metabolic disorders (MUO), and to a control group of normal-weight children using carotid intima-...

    Authors: Giovanni Farello, Annarita Antenucci, Stefano Stagi, Chiara Mazzocchetti, Franco Ciocca and Alberto Verrotti

    Citation: BMC Cardiovascular Disorders 2018 18:140

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  26. Content type: Research article

    To explore the effects of chronic intermittent hypoxia (CIH), which mimics sleep apnea syndrome, on the cardiac renin angiotensin system (RAS), and to investigate the cardiac protection of an angiotensin recep...

    Authors: Wanyu Wang, Ailing Song, Yiming Zeng, Xiaoyang Chen, Yixiang Zhang, Yonghong Shi, Yihua Lin and Wen Luo

    Citation: BMC Cardiovascular Disorders 2018 18:133

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  27. Content type: Research article

    Evidences suggest that central hemodynamics indexes are independent predictors of future cardiovascular events and all-cause mortality. Multiple factors have been pointed to have potential influence on central...

    Authors: Valeria Aparecida Costa-Hong, Henrique Cotchi Simbo Muela, Thiago Andrade Macedo, Allan Robson Kluser Sales and Luiz Aparecido Bortolotto

    Citation: BMC Cardiovascular Disorders 2018 18:123

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  28. Content type: Research article

    The skeletal muscle mass-to-visceral fat area ratio (SVR) has been linked to arterial stiffness in non-diabetic adults. We examined the association between the SVR and arterial stiffness in patients with type ...

    Authors: Jing Xu, Xiaoyan Pan, Haili Liang, Yi Lin, Yilian Hong, Qiya Si, Feixia Shen and Xuejiang Gu

    Citation: BMC Cardiovascular Disorders 2018 18:89

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  29. Content type: Research article

    To compare the reproducibility in total cholesterol (TC), systolic blood pressure (BP), and the resulting Systematic COronary Risk Evaluation (SCORE) obtained by an in-office cardio-preventive screening progra...

    Authors: Sabina Ulbricht, Stefan Gross, Eva Brammen, Franziska Weymar, Ulrich John, Christian Meyer and Marcus Dörr

    Citation: BMC Cardiovascular Disorders 2018 18:84

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  30. Content type: Research article

    Increased arterial stiffness (iAS) and microalbuminuria (MAU), which may occur simultaneously or separately in the general population and share similar risk factors, are markers of macro- and microvascular inj...

    Authors: Rujia Miao, Liuxin Wu, Ping Ni, Yue Zeng and Zhiheng Chen

    Citation: BMC Cardiovascular Disorders 2018 18:83

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  31. Content type: Research article

    Due to a relative lack of outpatient heart failure (HF) clinical registries, we aimed to describe symptoms, signs, and medication treatment among ambulatory patients with heart failure (HF) over time.

    Authors: Larry A. Allen, Fengming Tang, Philip Jones, Tracie Breeding, Angelo Ponirakis and Stuart J. Turner

    Citation: BMC Cardiovascular Disorders 2018 18:80

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  32. Content type: Research article

    The benefits of supervised physical activity programs in cardiac rehabilitation have been amply demonstrated, but the quantity of physical activity often declines quickly once supervision ends. This trial asse...

    Authors: Marion Fournier, Rémi Radel, Laurent Bailly, Christian Pradier, Roxane Fabre, Alain Fuch, Philippe Mossé, Jean-Jacques Domerego, Jocelyn Gal and Fabienne d’Arripe-Longueville

    Citation: BMC Cardiovascular Disorders 2018 18:77

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  33. Content type: Research article

    Centenarians refer to a special group who have outlived most of their fellows. Body shape and abdominal obesity have been identified as cardiovascular disease (CVD) risk factors. Our study aimed to evaluate th...

    Authors: Qiao Zhu, Xiao-Bing Wang, Yao Yao, Chao-Xue Ning, Xiao-Ping Chen, Fu-Xin Luan and Ya-Li Zhao

    Citation: BMC Cardiovascular Disorders 2018 18:73

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  34. Content type: Research article

    The present study sought to explore the relationship of common cardiovascular disease risk factors and noncoding RNAs with essential hypertension (EH).

    Authors: Shiying Chen, Rong Chen, Tingxing Zhang, Shaowei Lin, Zhou Chen, Bi Zhao, Huangyuan Li and Siying Wu

    Citation: BMC Cardiovascular Disorders 2018 18:58

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  35. Content type: Research article

    High salt intake increases blood pressure (BP) and hypertension risk. This study aimed to examine association of urinary sodium excretion with BP and hypertension correlates among Cameroonian pygmies under hun...

    Authors: Daniel Lemogoum, William Ngatchou, Claude Bika Lele, Cecile Okalla, Marc Leeman, Jean-Paul Degaute and Philippe van de Borne

    Citation: BMC Cardiovascular Disorders 2018 18:49

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  36. Content type: Research article

    Antioxidants have shown great promise in stroke prevention. Diarylheptanoids (also known as diphenylheptanoids) are a small class of plant secondary metabolites that possess antioxidant activity greater than t...

    Authors: Cong Lan, Xinjian Chen, Yuxun Zhang, Wei Wang, Wei Eric Wang, Yukai Liu, Yue Cai, Hongmei Ren, Shuo Zheng, Lin Zhou and Chunyu Zeng

    Citation: BMC Cardiovascular Disorders 2018 18:43

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  37. Content type: Research article

    Epicardial adipose tissue (EAT) is an emerging cardio-metabolic risk factor and has been shown to correlate with adverse cardiovascular (CV) outcome; however the underlying pathophysiology of this link is not ...

    Authors: Shaween Al-Talabany, Ify Mordi, J. Graeme Houston, Helen M. Colhoun, Jonathan R. Weir-McCall, Shona Z. Matthew, Helen C. Looker, Daniel Levin, Jill J. F. Belch, Fiona Dove, Faisel Khan and Chim C. Lang

    Citation: BMC Cardiovascular Disorders 2018 18:31

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  38. Content type: Research article

    Inconsistent conclusions have been reported for the genetic relationship between CYP4F2 (Cytochrome P450 Family 4 Subfamily F Member 2) polymorphisms and the susceptibility to cardiovascular and cerebrovascular d...

    Authors: Tao Zhang, Kuiying Yu and Xuhua Li

    Citation: BMC Cardiovascular Disorders 2018 18:29

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  39. Content type: Research article

    The rate of blood pressure (BP) control in adult hypertensive patients is poor and the reasons for poor control of BP pressure are not fully understood globally. This study aimed to assess the rate and factors...

    Authors: Saeed M. Omar, Osama Elnour, Gamal K. Adam, Osman E. Osman and Ishag Adam

    Citation: BMC Cardiovascular Disorders 2018 18:26

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  40. Content type: Research article

    Xanthine oxidase inhibitors (XOI), classified as purine-like (allopurinol and oxypurinol) and non-purine (febuxostat and topiroxostat) XOI, present antioxidant properties by reducing the production of reactive...

    Authors: Markus Bredemeier, Lediane Moreira Lopes, Matheus Augusto Eisenreich, Sheila Hickmann, Guilherme Kopik Bongiorno, Rui d’Avila, André Luis Bittencourt Morsch, Fernando da Silva Stein and Guilherme Gomes Dias Campos

    Citation: BMC Cardiovascular Disorders 2018 18:24

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  41. Content type: Debate

    National estimates of ‘heart age’ by government health organisations in the US, UK and China show most people have an older heart age than current age. While most heart age calculators are promoted as a commun...

    Authors: Carissa Bonner, Katy Bell, Jesse Jansen, Paul Glasziou, Les Irwig, Jenny Doust and Kirsten McCaffery

    Citation: BMC Cardiovascular Disorders 2018 18:19

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  42. Content type: Research article

    Heart rate (HR) is a prognostic marker that is increasingly used as a therapeutic target in patients with cardiovascular disease. The association between resting and mean HR remains unclear. We therefore set o...

    Authors: Marlena V. Habal, Kumaraswamy Nanthakumar, Peter C. Austin, Cassandra Freitas, Christopher Labos and Douglas S. Lee

    Citation: BMC Cardiovascular Disorders 2018 18:17

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  43. Content type: Research article

    Hypertrophic cardiomyopathy (HCM) is a genetic disease was characterised by left ventricular hypertrophy (LVH), myocardial fibrosis, fiber disarray. The short-axis systolic function is important in left ventri...

    Authors: Jun Huang, Zi-Ning Yan, Yi-Fei Rui, Li Fan, Chang Liu and Jie Li

    Citation: BMC Cardiovascular Disorders 2018 18:13

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  44. Content type: Research article

    The diagnosis of hypertension in children is complex because based on normative values by sex, age and height, and these values vary depending on the environment. Available BP references used, because of the a...

    Authors: Emmanuel Kiyana Muyumba, Dophra Ngoy Nkulu, Clarence Kaut Mukeng, Jacques Mbaz Musung, Placide Kambola Kakoma, Christian Ngama Kakisingi, Oscar Numbi Luboya, Françoise Kaj Malonga, Justin Kalungwe Kizonde, Olivier Mukuku and Weili Yan

    Citation: BMC Cardiovascular Disorders 2018 18:9

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  45. Content type: Research article

    Microvascular rarefaction influences peripheral vascular resistance, perfusion and metabolism by affecting blood pressure and flow pattern. In hypertension microvascular rarefaction has been described in exper...

    Authors: Agnes J. Bosch, Joanna M. Harazny, Iris Kistner, Stefanie Friedrich, Joanna Wojtkiewicz and Roland E. Schmieder

    Citation: BMC Cardiovascular Disorders 2017 17:300

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  46. Content type: Research article

    To evaluate association of 24 h–systolic blood pressure (SBP) variability and obstructive sleep apnea (OSA) as defined by the apnea-hypopnea index ≥5/h; and association of 24 h–SBP variability and prevalent ca...

    Authors: Xiao Ke, Yan Sun, Rongfeng Yang, Jiawen Liang, Shaoyun Wu, Chengheng Hu and Xing Wang

    Citation: BMC Cardiovascular Disorders 2017 17:287

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  47. Content type: Research article

    The purpose of this study was to assess the functional effects and acceptability of rocker-soled shoes that were designed to relatively “unload” the calf muscles during walking in people with calf claudication...

    Authors: Garry A. Tew, Ahmed Shalan, Alastair R. Jordan, Liz Cook, Elizabeth S. Coleman, Caroline Fairhurst, Catherine Hewitt, Stephen W. Hutchins and Andrew Thompson

    Citation: BMC Cardiovascular Disorders 2017 17:283

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  48. Content type: Research article

    Ideal cardiovascular health (CVH) is related to a low cardiovascular disease risk profile. This study aimed to investigate CVH metrics with both the biomarkers and markers of subclinical impairments of cardiov...

    Authors: Ya-Qin Wang, Chang-Fa Wang, Ling Zhu, Hong Yuan, Liu-Xin Wu and Zhi-Heng Chen

    Citation: BMC Cardiovascular Disorders 2017 17:269

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