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Coronary artery disease

Section edited by Fabrizio D'ascenzo
This section concerns all aspects of coronary artery disease including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

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  1. Content type: Research article

    Klotho, possibly an age-regulating protein, is considered an important factor contributing to the lifespan and pathophysiology of hypertension and coronary artery disease (CAD). The present study was carried o...

    Authors: Hamed Akbari, Gholamreza Asadikaram, Hamid Aria, Saba Fooladi, Sina Vakili and Mohammad Masoumi

    Citation: BMC Cardiovascular Disorders 2018 18:237

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  2. Content type: Study protocol

    Plaque composition and morphologic characteristics identified by virtual histology intravascular ultrasound (VH-IVUS) can determine plaques at increased risk of clinical events following percutaneous coronary ...

    Authors: Yin Liu, Hai-Bo Wang, Xiang Li, Jian-Yong Xiao, Ji-Xiang Wang, Kathleen H. Reilly, Bo Sun and Jing Gao

    Citation: BMC Cardiovascular Disorders 2018 18:233

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  3. Content type: Case report

    In the era of primary percutaneous coronary intervention (PPCI), the incidence of post-cardiac injury syndrome (PCIS) in patients with acute myocardial infarction (AMI) following PPCI has become less common. H...

    Authors: Yan Gao, Nanette H. Bishopric, Hong-wei Chen, Jiang-tao Li, Yu-lang Huang and He-xun Huang

    Citation: BMC Cardiovascular Disorders 2018 18:234

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  4. Content type: Research article

    The prognostic significance of changes in mean platelet volume (MPV) during hospitalization in ST segment elevation myocardial infarction (STEMI) patients underwent primary percutaneous coronary intervention (...

    Authors: Eyup Avci, Tuncay Kiris, Aykan Çelik, Eser Variş, Fatma Kayaalti Esin, Diyar Köprülü and Hasan Kadi

    Citation: BMC Cardiovascular Disorders 2018 18:226

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  5. Content type: Research article

    Ticagrelor has been acknowledged as a new oral antagonist of P2Y12-adenosine diphosphate receptor, as a strategy with more rapid onset as well as more significant platelet inhibition function in acute coronary...

    Authors: Dong Wang, Xiao-Hong Yang, Ji-Dong Zhang, Rui-Bin Li, Min Jia and Xiao-Ran Cui

    Citation: BMC Cardiovascular Disorders 2018 18:217

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  6. Content type: Research article

    To decrease the morbidity burden of cardiovascular disease and to avoid the development of potentially preventable complications, early assessment and treatment of acute coronary syndrome (ACS) are important. ...

    Authors: Mats Holmberg, Henrik Andersson, Karin Winge, Camilla Lundberg, Thomas Karlsson, Johan Herlitz and Birgitta Wireklint Sundström

    Citation: BMC Cardiovascular Disorders 2018 18:216

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  7. Content type: Research article

    Obstructive sleep apnea (OSA) and insomnia are frequent sleep problems that are associated with poor prognosis in patients with coronary heart disease. The mechanisms linking poor sleep with an increased cardi...

    Authors: Roland von Känel, Mary Princip, Jean-Paul Schmid, Jürgen Barth, Hansjörg Znoj, Ulrich Schnyder and Rebecca E. Meister-Langraf

    Citation: BMC Cardiovascular Disorders 2018 18:213

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  8. Content type: Research article

    Compared to ST-segment elevation myocardial infarction (STEMI) patients who present at centres with catheterization facilities, those transferred for primary percutaneous coronary intervention (PCI) have subst...

    Authors: Oumin Shi, Anam M. Khan, Mohammad R. Rezai, Cynthia A. Jackevicius, Jafna Cox, Clare L. Atzema, Dennis T. Ko, Thérèse A. Stukel, Laurie J. Lambert, Madhu K. Natarajan, Zhi-jie Zheng and Jack V. Tu

    Citation: BMC Cardiovascular Disorders 2018 18:204

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  9. Content type: Research article

    We conducted a randomized controlled trial to investigate whether an additional platelet inhibition with tirofiban would reduce the extent of myocardial damage and prevent periprocedural myonecrosis in patient...

    Authors: Wonjae Lee, Jung-Won Suh, Jin Joo Park, Chang-Hwan Yoon, Young-Seok Cho, Tae-Jin Youn and In-Ho Chae

    Citation: BMC Cardiovascular Disorders 2018 18:201

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  10. Content type: Research article

    Receptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or a...

    Authors: Juho Heliste, Anne Jokilammi, Ilkka Paatero, Deepankar Chakroborty, Christoffer Stark, Timo Savunen, Maria Laaksonen and Klaus Elenius

    Citation: BMC Cardiovascular Disorders 2018 18:196

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  11. Content type: Research article

    Experimental studies suggest that morphine may protect the myocardium against ischemia-reperfusion injury by activating salvage kinase pathways. The objective of this two-center, randomized, double-blind, cont...

    Authors: Philippe Le Corvoisier, Romain Gallet, Pierre-François Lesault, Etienne Audureau, Muriel Paul, Julien Ternacle, Saïd Ghostine, Stéphane Champagne, Raphaele Arrouasse, Dalila Bitari, Gauthier Mouillet, Jean-Luc Dubois-Randé, Alain Berdeaux, Bijan Ghaleh, Jean-François Deux and Emmanuel Teiger

    Citation: BMC Cardiovascular Disorders 2018 18:193

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  12. Content type: Research article

    Shock index(SI) is a conventional predictive marker for haemodynamic state. Its breakpoint varies by different conditions according to previous studies. The current study was performed to evaluate the capabili...

    Authors: Zhonghai Wei, Jian Bai, Qing Dai, Han Wu, Shuaihua Qiao, Biao Xu and Lian Wang

    Citation: BMC Cardiovascular Disorders 2018 18:188

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  13. Content type: Research article

    Patients with renal impairment often left out from most major clinical trials assessing the optimal treatment for ST-elevation myocardial infarction (STEMI). Large body of evidence from various cardiovascular ...

    Authors: Muhammad Dzafir Ismail, Maisarah Jalalonmuhali, Zaid Azhari, Jeevitha Mariapun, Zhen-Vin Lee, Imran Zainal Abidin, Wan Azman Wan Ahmad and Ahmad Syadi Mahmood Zuhdi

    Citation: BMC Cardiovascular Disorders 2018 18:184

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  14. Content type: Research article

    Thyroid hormones deeply influence the cardiovascular system; however, the association between the fT3/fT4 ratio and the clinical outcome in euthyroid patients with acute myocardial infarction (AMI) undergoing ...

    Authors: Tongtong Yu, Chunyang Tian, Jia Song, Dongxu He, Jiake Wu, Zongyu Wen, Zhijun Sun and Zhaoqing Sun

    Citation: BMC Cardiovascular Disorders 2018 18:181

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  15. Content type: Research article

    Coronary artery disease (CAD) is showing an increasing trend in young adults. Cigarette smoking has been shown to be a major cause of premature CAD. Previous studies have also shown that hyperuricemia (HUA) is...

    Authors: Sai Lv, Wei Liu, Yujie Zhou, Yuyang Liu, Dongmei Shi, Yingxin Zhao and Xiaoli Liu

    Citation: BMC Cardiovascular Disorders 2018 18:178

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  16. Content type: Research article

    Reliability of models for estimating pretest probability (PTP) of obstructive coronary artery disease (CAD) has not been investigated in individuals at low extreme of traditional risk factor (RF) burden. Thus,...

    Authors: Minghui Wang, Yujie Liu, Xiujun Zhou, Jia Zhou, Hong Zhang and Ying Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:176

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  17. Content type: Research article

    Non-obstructive coronary artery disease (NOCAD) is a common finding on coronary angiography. Our goal was to evaluate the long-term prognosis of NOCAD patients with stable angina (SA).

    Authors: Christine K. Kissel, Guanmin Chen, Danielle A. Southern, P. Diane Galbraith and Todd J. Anderson

    Citation: BMC Cardiovascular Disorders 2018 18:173

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  18. Content type: Research article

    Development of collateral circulation in coronary artery disease is cardio-protective. A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activatio...

    Authors: Edward C. A. Marks, Tom M. Wilkinson, Chris M. Frampton, Lorraine Skelton, Anna P. Pilbrow, Tim G. Yandle, Chris J. Pemberton, Robert N. Doughty, Gillian A. Whalley, Chris J. Ellis, Richard W. Troughton, Maurice C. Owen, Neil R. Pattinson, Vicky A. Cameron, A. Mark Richards, Steven P. Gieseg…

    Citation: BMC Cardiovascular Disorders 2018 18:169

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  19. Content type: Research article

    Cardiac rehabilitation improves prognosis after an acute myocardial infarction (AMI), however, the optimal method of implementation is unknown. The aim of the study was to evaluate the effect of individually-t...

    Authors: Halldora Ögmundsdottir Michelsen, Marie Nilsson, Fredrik Scherstén, Ingela Sjölin, Alexandru Schiopu and Margret Leosdottir

    Citation: BMC Cardiovascular Disorders 2018 18:167

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  20. Content type: Research article

    The Orsiro biodegradable polymer sirolimus-eluting stent (O-SES) is a new-generation biodegradable polymer drug-eluting stent with the thinnest strut thickness to date developed to improve the percutaneous tre...

    Authors: Ping Zhu, Xin Zhou, Chenliang Zhang, Huakang Li, Zhihui Zhang and Zhiyuan Song

    Citation: BMC Cardiovascular Disorders 2018 18:170

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  21. Content type: Research article

    The use of inappropriate elective Percutaneous Coronary Intervention (PCI) has decreased over time, but hospital-level variation in the use of inappropriate PCI persists. Understanding the barriers and facilit...

    Authors: Anne Lambert-Kerzner, Charles Maynard, Marina McCreight, Amy Ladebue, Katherine M. Williams, Kelty B. Fehling and Steven M. Bradley

    Citation: BMC Cardiovascular Disorders 2018 18:164

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  22. Content type: Research article

    Adaptor-related protein complex 2 alpha 2 subunit (AP2A2) gene encodes a protein-a subunit of the AP-2 adaptor protein complex. Evidence has revealed that benzodiazepine receptor-associated protein 1 (BZRAP1) ...

    Authors: Sibo Wang, Zhihui Ma, Yongjun Zhang, Yankui Ding, Zhong Chen and Liansheng Wang

    Citation: BMC Cardiovascular Disorders 2018 18:161

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  23. Content type: Research article

    Understanding the determinants associated with prediabetes and type 2 diabetes in coronary patients may help to individualize treatment and modelling interventions. We sought to identify sociodemographic, medi...

    Authors: John Munkhaugen, Jøran Hjelmesæth, Jan Erik Otterstad, Ragnhild Helseth, Stina Therese Sollid, Erik Gjertsen, Lars Gullestad, Joep Perk, Torbjørn Moum, Einar Husebye and Toril Dammen

    Citation: BMC Cardiovascular Disorders 2018 18:160

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  24. Content type: Research article

    Angina pectoris (AP) and unheralded myocardial infarction (MI) are considered random clinical equivalents of ischemic heart disease (IHD). Aim of the study was to evaluate the long-term progression of AP as op...

    Authors: Clara Carpeggiani, Claudio Michelassi, Patrizia Landi and Antonio L’Abbate

    Citation: BMC Cardiovascular Disorders 2018 18:156

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  25. Content type: Research article

    The xanthine oxidase inhibitor allopurinol that is commonly used to treat gout, has been suggested to have pleiotropic effects that are likely to reduce the incidence of myocardial infarction (MI) in at risk i...

    Authors: Tejas P. Singh, Tristan Skalina, Daniel Nour, Aarya Murali, Sean Morrison, Joseph V. Moxon and Jonathan Golledge

    Citation: BMC Cardiovascular Disorders 2018 18:143

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  26. Content type: Correspondence

    The potential life-threatening consequences of catecholamine use for emergency circulatory support in Takotsubo cardiomyopathy-related acute heart failure is a major challenge in cardiovascular emergences. In ...

    Authors: Michael Dandel and Roland Hetzer

    Citation: BMC Cardiovascular Disorders 2018 18:144

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  27. Content type: Research article

    Despite marked advances in our understanding of the pathophysiology of the coronary slow flow phenomenon (CSFP), the exact mechanism remains unclear. Previous studies have suggested that CSFP might be associat...

    Authors: Yong Wang, Mou-jie Liu, Hui-min Yang, Chun-yan Ma, Peng-yu Jia, Da-lin Jia and Ai-jie Hou

    Citation: BMC Cardiovascular Disorders 2018 18:138

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  28. Content type: Study protocol

    In Denmark and other countries, there has been a shift in the management of patients with an implantable cardioverter defibrillator (ICD) with remote device monitoring largely replacing in-hospital visits. Les...

    Authors: Susanne S. Pedersen, Søren J. Skovbakke, Uffe K. Wiil, Thomas Schmidt, Rene dePont Christensen, Carl J. Brandt, Jan Sørensen, Michael Vinther, Charlotte E. Larroudé, Thomas M. Melchior, Sam Riahi, Kim G. E. Smolderen, John A. Spertus, Jens B. Johansen and Jens C. Nielsen

    Citation: BMC Cardiovascular Disorders 2018 18:136

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  29. Content type: Research article

    Atrial and ventricular cardiac arrhythmias are one of the most common early complications after cardiac surgery and these serve as a major cause of mortality and morbidity after cardiac revascularization. We w...

    Authors: Shirvan Salaminia, Fatemeh Sayehmiri, Parvin Angha, Koroush Sayehmiri and Morteza Motedayen

    Citation: BMC Cardiovascular Disorders 2018 18:129

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  30. Content type: Research article

    The stenosis of the coronary arteries is usually caused by atherosclerosis. Hemodynamic significance of patient-specific coronary stenoses and the risk of its progression may be assessed by comparing the hemod...

    Authors: Zbigniew Malota, Jan Glowacki, Wojciech Sadowski and Marcin Kostur

    Citation: BMC Cardiovascular Disorders 2018 18:132

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  31. Content type: Research article

    Nonculprit lesions are the major cause of future cardiovascular events. However, the natural course of nonculprit lesions and angiographic predictors of plaque progression are not well-studied. The purpose of ...

    Authors: Jeehoon Kang, Kyung Woo Park, Michael S. Lee, Chengbin Zheng, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo and Hyo-Soo Kim

    Citation: BMC Cardiovascular Disorders 2018 18:130

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  32. Content type: Research article

    Spontaneous reperfusion (SR) and early infarct related artery (IRA) patency before primary percutaneous coronary intervention (PPCI) might bring extra benefit for patients with ST-segment elevation myocardial ...

    Authors: Jing Li, Ying Zhou, Yaowen Zhang and Jingang Zheng

    Citation: BMC Cardiovascular Disorders 2018 18:125

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  33. Content type: Case report

    Percutaneous coronary interventions (PCI) of old calcified saphenous vein grafts (SVGs) is challenging and is associated with a considerably high risk of adverse ischemic events in the short- and long-term as ...

    Authors: Mariano Pellicano, Vincent Floré, Emanuele Barbato and Bernard De Bruyne

    Citation: BMC Cardiovascular Disorders 2018 18:122

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  34. Content type: Research article

    It is well recognized that cardio- vascular risk factors lead to histological and functional changes in aorta, and aortic stiffness is the best predictor of cardiovascular morbidity and mortality. In this stud...

    Authors: Fereshteh Ghaderi, Hossein Samim, Faeze Keihanian and Seyed Ali Danesh Sani

    Citation: BMC Cardiovascular Disorders 2018 18:121

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  35. Content type: Research article

    In a previous study, we found that titrating clopidogrel maintenance doses (MDs) according to vasodilator-stimulated phosphoprotein (VASP) monitoring minimised the rate of major adverse cardiovascular and cere...

    Authors: Chaoyue Hu, Xumin Zhang, Yonghua Liu, Yang Gao, Xiaohong Zhao, Hua Zhou, Yu Luo, Yaling Liu and Xiaodong Wang

    Citation: BMC Cardiovascular Disorders 2018 18:120

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  36. Content type: Case report

    Kawasaki disease is an acute febrile disease with mucocutaneous and cardiovascular involvement affecting infants and young children. Though coronary artery abnormalities are common in Kawasaki disease, no cons...

    Authors: Xu Guo, Xiaoou Wang, Xinzhong Zhang, Ahmed O. Ahmed, David H. Hsi and Daqing Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:118

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  37. Content type: Research article

    Transmural acute myocardial infarction (AMI) is associated with a high risk for ventricular arrhythmia before, during and after treatment. Consequently, it is recommended that patients diagnosed with transmura...

    Authors: Marco Albanese, Korhan Alpaslan, Taoufik Ouarrak, Peter Merguet, Steffen Schneider and Wolfgang Schöls

    Citation: BMC Cardiovascular Disorders 2018 18:116

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  38. Content type: Research article

    Although several meta-analyses have demonstrated the utility of intravascular ultrasound (IVUS) in guiding drug-eluting stent (DES) implantation compared to angiography-guidance, there has been a dearth of evi...

    Authors: Yue Wang, Gary S. Mintz, Zhichun Gu, Yue Qi, Yue Wang, Mengru Liu and Xiaofan Wu

    Citation: BMC Cardiovascular Disorders 2018 18:115

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  39. Content type: Research article

    There have been limited data on the impact of hyperuricemia on long-term clinical outcomes after percutaneous coronary intervention (PCI) for in-stent restenosis (ISR).

    Authors: Hyung Joon Joo, Han Saem Jeong, Hyungdon Kook, Seung Hun Lee, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu and Do-Sum Lim

    Citation: BMC Cardiovascular Disorders 2018 18:114

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  40. Content type: Research article

    Oxidative stress is increased in hyperuricemic patients with acute myocardial infarction (AMI). Use of sulfhydryl ACE-inhibitors (ACEIs), such as zofenopril or captopril, plus xanthine oxidase inhibitors (XOIs), ...

    Authors: Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti and Ettore Ambrosioni

    Citation: BMC Cardiovascular Disorders 2018 18:112

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  41. Content type: Research article

    Myocardial bridge (MB) is generally described as a congenital benign variation. Previous studies have suggested that MB prevents atherosclerotic plaques from accumulating within the bridge segment but promotes...

    Authors: Lisheng Jiang, Min Zhang, Hong Zhang, Lan Shen, Qin Shao, Linghong Shen and Ben He

    Citation: BMC Cardiovascular Disorders 2018 18:105

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  42. Content type: Research article

    The relationship between platelet reactivity and long-term clinical outcomes remains controversial. The present prospective study was designed to explore the association between high platelet reactivity (HPR) ...

    Authors: Xiao-Fei Gao, Shu Lu, Zhen Ge, Guang-Feng Zuo, Zhi-Mei Wang, Feng Wang, Xiang-Quan Kong, Da-Yang Chai, Shao-Liang Chen and Jun-Jie Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:103

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  43. Content type: Research article

    The precise relationship between increased thrombolysis in myocardial infarction (TIMI) frame counts and the topographical extent of isolated coronary artery ectasia (CAE) has not been fully explained. New par...

    Authors: Wei Wu, Shuyang Zhang, Yuchao Guo, Ruifeng Liu, Zhujun Shen, Xueqing Zhu and Zhenyu Liu

    Citation: BMC Cardiovascular Disorders 2018 18:102

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  44. Content type: Study protocol

    Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) and they represent independent risk factors for disability, morbidity, hospital readmission...

    Authors: Elisabetta Tonet, Elisa Maietti, Giorgio Chiaranda, Francesco Vitali, Matteo Serenelli, Giulia Bugani, Gianni Mazzoni, Rossella Ruggiero, Jonathan Myers, Giovanni Quinto Villani, Ursula Corvi, Giovanni Pasanisi, Simone Biscaglia, Rita Pavasini, Giulia Ricci Lucchi, Gianluigi Sella…

    Citation: BMC Cardiovascular Disorders 2018 18:98

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  45. Content type: Research article

    Personal resources are identified as important for the ability to return to work (RTW) for patients with ischaemic heart disease (IHD) or heart failure (HF) undergoing cardiac rehabilitation (CR). The patient ...

    Authors: Birgitte Laier Bitsch, Claus Vinther Nielsen, Christina Malmose Stapelfeldt and Vibeke Lynggaard

    Citation: BMC Cardiovascular Disorders 2018 18:101

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  46. Content type: Research article

    Hong Kong (HK) and Guangzhou (GZ) are cities in China with different healthcare systems. This study aimed to compare 30-day and 6-month mortality and characteristics of patients with suspected cardiac chest pa...

    Authors: Huilin Jiang, Yunmei Li, Junrong Mo, Xiaohui Chen, Min Li, Peiyi Lin, Kevin K. C. Hung, Timothy H. Rainer and Colin A. Graham

    Citation: BMC Cardiovascular Disorders 2018 18:95

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  47. Content type: Research article

    Diabetes is among the strongest predictors of outcome after coronary artery stenting and the incidence of negative outcomes is still high in this specific group. Data of long-term outcomes comparing diabetic p...

    Authors: Remzi Anadol, Katharina Schnitzler, Liv Lorenz, Melissa Weissner, Helen Ullrich, Alberto Polimeni, Thomas Münzel and Tommaso Gori

    Citation: BMC Cardiovascular Disorders 2018 18:92

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  48. Content type: Research article

    Mitral regurgitation in ischemic heart disease (IMR) is a strong predictor of outcome but until now, pathophysiology is not sufficiently understood and treatment is not satisfying. We aimed to systematically e...

    Authors: Caroline Morbach, Diego Bellavia, Stefan Störk and Lissa Sugeng

    Citation: BMC Cardiovascular Disorders 2018 18:93

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