Skip to content


Coronary artery disease

Section edited by Fabrizio D'ascenzo
This section concerns all aspects of coronary artery disease including but not limited to: prevention, diagnosis and management, as well as related molecular genetics, and pathophysiology.

Page 1 of 8

  1. Content type: Research article

    Patients with renal impairment often left out from most major clinical trials assessing the optimal treatment for ST-elevation myocardial infarction (STEMI). Large body of evidence from various cardiovascular ...

    Authors: Muhammad Dzafir Ismail, Maisarah Jalalonmuhali, Zaid Azhari, Jeevitha Mariapun, Zhen-Vin Lee, Imran Zainal Abidin, Wan Azman Wan Ahmad and Ahmad Syadi Mahmood Zuhdi

    Citation: BMC Cardiovascular Disorders 2018 18:184

    Published on:

  2. Content type: Research article

    Thyroid hormones deeply influence the cardiovascular system; however, the association between the fT3/fT4 ratio and the clinical outcome in euthyroid patients with acute myocardial infarction (AMI) undergoing ...

    Authors: Tongtong Yu, Chunyang Tian, Jia Song, Dongxu He, Jiake Wu, Zongyu Wen, Zhijun Sun and Zhaoqing Sun

    Citation: BMC Cardiovascular Disorders 2018 18:181

    Published on:

  3. Content type: Research article

    Coronary artery disease (CAD) is showing an increasing trend in young adults. Cigarette smoking has been shown to be a major cause of premature CAD. Previous studies have also shown that hyperuricemia (HUA) is...

    Authors: Sai Lv, Wei Liu, Yujie Zhou, Yuyang Liu, Dongmei Shi, Yingxin Zhao and Xiaoli Liu

    Citation: BMC Cardiovascular Disorders 2018 18:178

    Published on:

  4. Content type: Research article

    Reliability of models for estimating pretest probability (PTP) of obstructive coronary artery disease (CAD) has not been investigated in individuals at low extreme of traditional risk factor (RF) burden. Thus,...

    Authors: Minghui Wang, Yujie Liu, Xiujun Zhou, Jia Zhou, Hong Zhang and Ying Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:176

    Published on:

  5. Content type: Research article

    Non-obstructive coronary artery disease (NOCAD) is a common finding on coronary angiography. Our goal was to evaluate the long-term prognosis of NOCAD patients with stable angina (SA).

    Authors: Christine K. Kissel, Guanmin Chen, Danielle A. Southern, P. Diane Galbraith and Todd J. Anderson

    Citation: BMC Cardiovascular Disorders 2018 18:173

    Published on:

  6. Content type: Research article

    Development of collateral circulation in coronary artery disease is cardio-protective. A key process in forming new blood vessels is attraction to occluded arteries of monocytes with their subsequent activatio...

    Authors: Edward C. A. Marks, Tom M. Wilkinson, Chris M. Frampton, Lorraine Skelton, Anna P. Pilbrow, Tim G. Yandle, Chris J. Pemberton, Robert N. Doughty, Gillian A. Whalley, Chris J. Ellis, Richard W. Troughton, Maurice C. Owen, Neil R. Pattinson, Vicky A. Cameron, A. Mark Richards, Steven P. Gieseg…

    Citation: BMC Cardiovascular Disorders 2018 18:169

    Published on:

  7. Content type: Research article

    Cardiac rehabilitation improves prognosis after an acute myocardial infarction (AMI), however, the optimal method of implementation is unknown. The aim of the study was to evaluate the effect of individually-t...

    Authors: Halldora Ögmundsdottir Michelsen, Marie Nilsson, Fredrik Scherstén, Ingela Sjölin, Alexandru Schiopu and Margret Leosdottir

    Citation: BMC Cardiovascular Disorders 2018 18:167

    Published on:

  8. Content type: Research article

    The Orsiro biodegradable polymer sirolimus-eluting stent (O-SES) is a new-generation biodegradable polymer drug-eluting stent with the thinnest strut thickness to date developed to improve the percutaneous tre...

    Authors: Ping Zhu, Xin Zhou, Chenliang Zhang, Huakang Li, Zhihui Zhang and Zhiyuan Song

    Citation: BMC Cardiovascular Disorders 2018 18:170

    Published on:

  9. Content type: Research article

    The use of inappropriate elective Percutaneous Coronary Intervention (PCI) has decreased over time, but hospital-level variation in the use of inappropriate PCI persists. Understanding the barriers and facilit...

    Authors: Anne Lambert-Kerzner, Charles Maynard, Marina McCreight, Amy Ladebue, Katherine M. Williams, Kelty B. Fehling and Steven M. Bradley

    Citation: BMC Cardiovascular Disorders 2018 18:164

    Published on:

  10. Content type: Research article

    Adaptor-related protein complex 2 alpha 2 subunit (AP2A2) gene encodes a protein-a subunit of the AP-2 adaptor protein complex. Evidence has revealed that benzodiazepine receptor-associated protein 1 (BZRAP1) ...

    Authors: Sibo Wang, Zhihui Ma, Yongjun Zhang, Yankui Ding, Zhong Chen and Liansheng Wang

    Citation: BMC Cardiovascular Disorders 2018 18:161

    Published on:

  11. Content type: Research article

    Understanding the determinants associated with prediabetes and type 2 diabetes in coronary patients may help to individualize treatment and modelling interventions. We sought to identify sociodemographic, medi...

    Authors: John Munkhaugen, Jøran Hjelmesæth, Jan Erik Otterstad, Ragnhild Helseth, Stina Therese Sollid, Erik Gjertsen, Lars Gullestad, Joep Perk, Torbjørn Moum, Einar Husebye and Toril Dammen

    Citation: BMC Cardiovascular Disorders 2018 18:160

    Published on:

  12. Content type: Research article

    Angina pectoris (AP) and unheralded myocardial infarction (MI) are considered random clinical equivalents of ischemic heart disease (IHD). Aim of the study was to evaluate the long-term progression of AP as op...

    Authors: Clara Carpeggiani, Claudio Michelassi, Patrizia Landi and Antonio L’Abbate

    Citation: BMC Cardiovascular Disorders 2018 18:156

    Published on:

  13. Content type: Research article

    The xanthine oxidase inhibitor allopurinol that is commonly used to treat gout, has been suggested to have pleiotropic effects that are likely to reduce the incidence of myocardial infarction (MI) in at risk i...

    Authors: Tejas P. Singh, Tristan Skalina, Daniel Nour, Aarya Murali, Sean Morrison, Joseph V. Moxon and Jonathan Golledge

    Citation: BMC Cardiovascular Disorders 2018 18:143

    Published on:

  14. Content type: Correspondence

    The potential life-threatening consequences of catecholamine use for emergency circulatory support in Takotsubo cardiomyopathy-related acute heart failure is a major challenge in cardiovascular emergences. In ...

    Authors: Michael Dandel and Roland Hetzer

    Citation: BMC Cardiovascular Disorders 2018 18:144

    Published on:

  15. Content type: Research article

    Despite marked advances in our understanding of the pathophysiology of the coronary slow flow phenomenon (CSFP), the exact mechanism remains unclear. Previous studies have suggested that CSFP might be associat...

    Authors: Yong Wang, Mou-jie Liu, Hui-min Yang, Chun-yan Ma, Peng-yu Jia, Da-lin Jia and Ai-jie Hou

    Citation: BMC Cardiovascular Disorders 2018 18:138

    Published on:

  16. Content type: Study protocol

    In Denmark and other countries, there has been a shift in the management of patients with an implantable cardioverter defibrillator (ICD) with remote device monitoring largely replacing in-hospital visits. Les...

    Authors: Susanne S. Pedersen, Søren J. Skovbakke, Uffe K. Wiil, Thomas Schmidt, Rene dePont Christensen, Carl J. Brandt, Jan Sørensen, Michael Vinther, Charlotte E. Larroudé, Thomas M. Melchior, Sam Riahi, Kim G. E. Smolderen, John A. Spertus, Jens B. Johansen and Jens C. Nielsen

    Citation: BMC Cardiovascular Disorders 2018 18:136

    Published on:

  17. Content type: Research article

    Atrial and ventricular cardiac arrhythmias are one of the most common early complications after cardiac surgery and these serve as a major cause of mortality and morbidity after cardiac revascularization. We w...

    Authors: Shirvan Salaminia, Fatemeh Sayehmiri, Parvin Angha, Koroush Sayehmiri and Morteza Motedayen

    Citation: BMC Cardiovascular Disorders 2018 18:129

    Published on:

  18. Content type: Research article

    The stenosis of the coronary arteries is usually caused by atherosclerosis. Hemodynamic significance of patient-specific coronary stenoses and the risk of its progression may be assessed by comparing the hemod...

    Authors: Zbigniew Malota, Jan Glowacki, Wojciech Sadowski and Marcin Kostur

    Citation: BMC Cardiovascular Disorders 2018 18:132

    Published on:

  19. Content type: Research article

    Nonculprit lesions are the major cause of future cardiovascular events. However, the natural course of nonculprit lesions and angiographic predictors of plaque progression are not well-studied. The purpose of ...

    Authors: Jeehoon Kang, Kyung Woo Park, Michael S. Lee, Chengbin Zheng, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo and Hyo-Soo Kim

    Citation: BMC Cardiovascular Disorders 2018 18:130

    Published on:

  20. Content type: Research article

    Spontaneous reperfusion (SR) and early infarct related artery (IRA) patency before primary percutaneous coronary intervention (PPCI) might bring extra benefit for patients with ST-segment elevation myocardial ...

    Authors: Jing Li, Ying Zhou, Yaowen Zhang and Jingang Zheng

    Citation: BMC Cardiovascular Disorders 2018 18:125

    Published on:

  21. Content type: Case report

    Percutaneous coronary interventions (PCI) of old calcified saphenous vein grafts (SVGs) is challenging and is associated with a considerably high risk of adverse ischemic events in the short- and long-term as ...

    Authors: Mariano Pellicano, Vincent Floré, Emanuele Barbato and Bernard De Bruyne

    Citation: BMC Cardiovascular Disorders 2018 18:122

    Published on:

  22. Content type: Research article

    It is well recognized that cardio- vascular risk factors lead to histological and functional changes in aorta, and aortic stiffness is the best predictor of cardiovascular morbidity and mortality. In this stud...

    Authors: Fereshteh Ghaderi, Hossein Samim, Faeze Keihanian and Seyed Ali Danesh Sani

    Citation: BMC Cardiovascular Disorders 2018 18:121

    Published on:

  23. Content type: Research article

    In a previous study, we found that titrating clopidogrel maintenance doses (MDs) according to vasodilator-stimulated phosphoprotein (VASP) monitoring minimised the rate of major adverse cardiovascular and cere...

    Authors: Chaoyue Hu, Xumin Zhang, Yonghua Liu, Yang Gao, Xiaohong Zhao, Hua Zhou, Yu Luo, Yaling Liu and Xiaodong Wang

    Citation: BMC Cardiovascular Disorders 2018 18:120

    Published on:

  24. Content type: Case report

    Kawasaki disease is an acute febrile disease with mucocutaneous and cardiovascular involvement affecting infants and young children. Though coronary artery abnormalities are common in Kawasaki disease, no cons...

    Authors: Xu Guo, Xiaoou Wang, Xinzhong Zhang, Ahmed O. Ahmed, David H. Hsi and Daqing Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:118

    Published on:

  25. Content type: Research article

    Transmural acute myocardial infarction (AMI) is associated with a high risk for ventricular arrhythmia before, during and after treatment. Consequently, it is recommended that patients diagnosed with transmura...

    Authors: Marco Albanese, Korhan Alpaslan, Taoufik Ouarrak, Peter Merguet, Steffen Schneider and Wolfgang Schöls

    Citation: BMC Cardiovascular Disorders 2018 18:116

    Published on:

  26. Content type: Research article

    Although several meta-analyses have demonstrated the utility of intravascular ultrasound (IVUS) in guiding drug-eluting stent (DES) implantation compared to angiography-guidance, there has been a dearth of evi...

    Authors: Yue Wang, Gary S. Mintz, Zhichun Gu, Yue Qi, Yue Wang, Mengru Liu and Xiaofan Wu

    Citation: BMC Cardiovascular Disorders 2018 18:115

    Published on:

  27. Content type: Research article

    There have been limited data on the impact of hyperuricemia on long-term clinical outcomes after percutaneous coronary intervention (PCI) for in-stent restenosis (ISR).

    Authors: Hyung Joon Joo, Han Saem Jeong, Hyungdon Kook, Seung Hun Lee, Jae Hyoung Park, Soon Jun Hong, Cheol Woong Yu and Do-Sum Lim

    Citation: BMC Cardiovascular Disorders 2018 18:114

    Published on:

  28. Content type: Research article

    Oxidative stress is increased in hyperuricemic patients with acute myocardial infarction (AMI). Use of sulfhydryl ACE-inhibitors (ACEIs), such as zofenopril or captopril, plus xanthine oxidase inhibitors (XOIs), ...

    Authors: Claudio Borghi, Stefano Omboni, Giorgio Reggiardo, Stefano Bacchelli, Daniela Degli Esposti and Ettore Ambrosioni

    Citation: BMC Cardiovascular Disorders 2018 18:112

    Published on:

  29. Content type: Research article

    Myocardial bridge (MB) is generally described as a congenital benign variation. Previous studies have suggested that MB prevents atherosclerotic plaques from accumulating within the bridge segment but promotes...

    Authors: Lisheng Jiang, Min Zhang, Hong Zhang, Lan Shen, Qin Shao, Linghong Shen and Ben He

    Citation: BMC Cardiovascular Disorders 2018 18:105

    Published on:

  30. Content type: Research article

    The relationship between platelet reactivity and long-term clinical outcomes remains controversial. The present prospective study was designed to explore the association between high platelet reactivity (HPR) ...

    Authors: Xiao-Fei Gao, Shu Lu, Zhen Ge, Guang-Feng Zuo, Zhi-Mei Wang, Feng Wang, Xiang-Quan Kong, Da-Yang Chai, Shao-Liang Chen and Jun-Jie Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:103

    Published on:

  31. Content type: Research article

    The precise relationship between increased thrombolysis in myocardial infarction (TIMI) frame counts and the topographical extent of isolated coronary artery ectasia (CAE) has not been fully explained. New par...

    Authors: Wei Wu, Shuyang Zhang, Yuchao Guo, Ruifeng Liu, Zhujun Shen, Xueqing Zhu and Zhenyu Liu

    Citation: BMC Cardiovascular Disorders 2018 18:102

    Published on:

  32. Content type: Study protocol

    Reduced physical performance and impaired mobility are common in elderly patients after acute coronary syndrome (ACS) and they represent independent risk factors for disability, morbidity, hospital readmission...

    Authors: Elisabetta Tonet, Elisa Maietti, Giorgio Chiaranda, Francesco Vitali, Matteo Serenelli, Giulia Bugani, Gianni Mazzoni, Rossella Ruggiero, Jonathan Myers, Giovanni Quinto Villani, Ursula Corvi, Giovanni Pasanisi, Simone Biscaglia, Rita Pavasini, Giulia Ricci Lucchi, Gianluigi Sella…

    Citation: BMC Cardiovascular Disorders 2018 18:98

    Published on:

  33. Content type: Research article

    Personal resources are identified as important for the ability to return to work (RTW) for patients with ischaemic heart disease (IHD) or heart failure (HF) undergoing cardiac rehabilitation (CR). The patient ...

    Authors: Birgitte Laier Bitsch, Claus Vinther Nielsen, Christina Malmose Stapelfeldt and Vibeke Lynggaard

    Citation: BMC Cardiovascular Disorders 2018 18:101

    Published on:

  34. Content type: Research article

    Hong Kong (HK) and Guangzhou (GZ) are cities in China with different healthcare systems. This study aimed to compare 30-day and 6-month mortality and characteristics of patients with suspected cardiac chest pa...

    Authors: Huilin Jiang, Yunmei Li, Junrong Mo, Xiaohui Chen, Min Li, Peiyi Lin, Kevin K. C. Hung, Timothy H. Rainer and Colin A. Graham

    Citation: BMC Cardiovascular Disorders 2018 18:95

    Published on:

  35. Content type: Research article

    Diabetes is among the strongest predictors of outcome after coronary artery stenting and the incidence of negative outcomes is still high in this specific group. Data of long-term outcomes comparing diabetic p...

    Authors: Remzi Anadol, Katharina Schnitzler, Liv Lorenz, Melissa Weissner, Helen Ullrich, Alberto Polimeni, Thomas Münzel and Tommaso Gori

    Citation: BMC Cardiovascular Disorders 2018 18:92

    Published on:

  36. Content type: Research article

    Mitral regurgitation in ischemic heart disease (IMR) is a strong predictor of outcome but until now, pathophysiology is not sufficiently understood and treatment is not satisfying. We aimed to systematically e...

    Authors: Caroline Morbach, Diego Bellavia, Stefan Störk and Lissa Sugeng

    Citation: BMC Cardiovascular Disorders 2018 18:93

    Published on:

  37. Content type: Technical advance

    Cardiac computed tomography (CT) is often performed in patients who are at high risk for lung cancer in whom screening is currently recommended. We tested diagnostic ability and radiation exposure of a novel u...

    Authors: Carlo Gaudio, Gennaro Petriello, Francesco Pelliccia, Alessandra Tanzilli, Alberto Bandiera, Gaetano Tanzilli, Francesco Barillà, Vincenzo Paravati, Massimo Pellegrini, Enrico Mangieri and Paolo Barillari

    Citation: BMC Cardiovascular Disorders 2018 18:90

    Published on:

  38. Content type: Research article

    Myocardial apoptosis is important in the pathogenesis and progression of myocardial infarction-induced heart failure (MI-HF). Renal sympathetic denervation (RDN) has become a promising therapeutic strategy for...

    Authors: Li Wang, Lijun Song, Chao Li, Qiaoli Feng, Mengping Xu, Zhuqing Li and Chengzhi Lu

    Citation: BMC Cardiovascular Disorders 2018 18:86

    Published on:

  39. Content type: Research article

    Currently, many methodological approaches have been developed to assess peripheral endothelial function. However, a development of the noninvasive and automated technique for routinely assessing endothelial fu...

    Authors: Daoyuan Si, Lujia Ni, Yunfei Wang, Jinsha Liu, Jining Yang and Ping Yang

    Citation: BMC Cardiovascular Disorders 2018 18:81

    Published on:

  40. Content type: Research article

    Due to limitations associated with clopidogrel following percutaneous coronary intervention (PCI), other newer oral anti-platelet agents are being studied. We aimed to systematically carry out a direct compari...

    Authors: Pravesh Kumar Bundhun and Feng Huang

    Citation: BMC Cardiovascular Disorders 2018 18:78

    Published on:

  41. Content type: Research article

    The neutrophil to lymphocyte ratio (NLR) is an indicator of systemic inflammation and a prognostic marker in patients with acute coronary syndrome (ACS). This study aims to investigate the value of NLR to pred...

    Authors: Sai Zhang, Jun Diao, Chunmei Qi, Jingjing Jin, Li Li, Xingjuan Gao, Lei Gong and Weiheng Wu

    Citation: BMC Cardiovascular Disorders 2018 18:75

    Published on:

  42. Content type: Research article

    We aimed to evaluate the impact of thrombus aspiration (TA) during primary percutaneous coronary intervention (P-PCI) in ‘real-world’ settings.

    Authors: Hélder Pereira, Daniel Caldeira, Rui Campante Teles, Marco Costa, Pedro Canas da Silva, Vasco da Gama Ribeiro, Vítor Brandão, Dinis Martins, Fernando Matias, Francisco Pereira-Machado, José Baptista, Pedro Farto e Abreu, Ricardo Santos, António Drummond, Henrique Cyrne de Carvalho, João Calisto…

    Citation: BMC Cardiovascular Disorders 2018 18:69

    Published on:

  43. Content type: Research article

    N-terminal pro B-type peptide (NT-proBNP) has been associated with risk of myocardial infarction (MI), but less is known about the relationship between NT-proBNP and very small non ST-elevation MI, also known ...

    Authors: Madeline R. Sterling, Raegan W. Durant, Joanna Bryan, Emily B. Levitan, Todd M. Brown, Yulia Khodneva, Stephen P. Glasser, Joshua S. Richman, George Howard, Mary Cushman and Monika M. Safford

    Citation: BMC Cardiovascular Disorders 2018 18:66

    Published on:

  44. Content type: Case report

    An unusual case of typical angina which occurred on a long haul flight is presented. This case is notable as this was the index presentation, with no previous symptoms prior to this. Physiological changes at a...

    Authors: Firas Al-Janabi, Regina Mammen, Grigoris Karamasis, John Davies and Thomas Keeble

    Citation: BMC Cardiovascular Disorders 2018 18:61

    Published on:

  45. Content type: Research article

    Cardiovascular disease is still the leading cause of premature death world-wide with factors like abdominal obesity, hypertension and dyslipidemia being central risk factors in the etiology. The aim of the pre...

    Authors: Matthias Lidin, Mai-Lis Hellénius, Monica Rydell-Karlsson and Elin Ekblom-Bak

    Citation: BMC Cardiovascular Disorders 2018 18:59

    Published on:

  46. Content type: Research article

    Valvular heart disease is a leading cause of cardiovascular mortality, especially in China. More than a half of valvular heart diseases are caused by acute rheumatic fever. microRNA is involved in many physiol...

    Authors: Qiyu Lu, Yi Sun, Yuyin Duan, Bin Li, Jianming Xia, Songhua Yu and Guimin Zhang

    Citation: BMC Cardiovascular Disorders 2018 18:53

    Published on:

  47. Content type: Research article

    Previous studies have shown that the presence of anemia is associated with increased short- and long-term outcomes in patients with acute myocardial infarction (AMI). This study aims at examining the impact of...

    Authors: Miriam Giovanna Colombo, Inge Kirchberger, Ute Amann, Margit Heier, Christian Thilo, Bernhard Kuch, Annette Peters and Christa Meisinger

    Citation: BMC Cardiovascular Disorders 2018 18:50

    Published on:

  48. Content type: Case report

    Severe obesity is asscociated with an increased risk of coronary artery disease (CAD) but non-invasive cardiac imaging modalities have important technical limits.

    Authors: Lukas Stoiber, Bernhard Schnackenburg, Rolf Gebker, Hanane Hireche-Chikaoui, Burkert Pieske and Sebastian Kelle

    Citation: BMC Cardiovascular Disorders 2018 18:47

    Published on:

  49. Content type: Research article

    Drug-eluting balloons (DEB) have significant value for treating coronary artery disease (CAD). However, the merits of using DEB versus drug-eluting stents (DES) to treat CAD remain controversial. Herein, we co...

    Authors: Lulu Liu, Bin Liu, Jiajun Ren, Gang Hui, Chao Qi and Junnan Wang

    Citation: BMC Cardiovascular Disorders 2018 18:46

    Published on: