The association of cardiac troponin and cardiovascular events in patients with concomitant heart failure preserved ejection fraction and atrial fibrillation

Table 3 Clinical outcomes according to the 99th percentile upper reference limit of hs-cTnI in patients with newly detected AF and concomitant HFpEF

	Non-elevated hs-cTnI	Elevated hs-cTnI	Unadjusted HR	P-value	Adjusted HR^a	P-value
	(< 99th percentile URL)	(≥ 99th percentile URL)	Unadjusted HR		Adjusted HR^a
	(n = 295)	(n = 174)	(95% CI)		(95% CI)
MACCE	56 (19.0)	50 (28.7)	1.52 (1.03–2.24)	0.03	1.54 (1.08–2.55)	0.03
All cause death	12 (4.1)	12 (6.9)	1.51 (0.66–3.47)	0.32	1.34 (0.57–3.12)	0.51
Heart failure-caused readmission	25 (8.5)	27 (15.5)	1.88 (1.08–3.25)	0.02	1.52 (0.86–2.67)	0.08
Revascularization-caused readmission	3 (1.0)	6 (3.4)	3.58 (0.89–14.33)	0.07	3.86 (1.39–15.09)	0.02
Stroke-caused readmission	20 (6.8)	15 (8.6)	1.12 (0.56–2.24)	0.75	1.02 (0.49–2.08)	0.96

MACCE Major adverse cardiac and cerebrovascular events, HFpEF Heart failure with preserved ejection fraction, AF Atrial fibrillation, hs-cTnI high-sensitivity cardiac troponin I, URL Upper reference limit, HR Hazard ratio, CI Confidence interval
^a Adjusted factors: age, female sex, previous heart failure, and use of loop diuretics

ISSN: 1471-2261