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Table 4 Association between LA parameters, clinical or other echocardiographic variables, and VO2max (mL/kg/min) in the univariate and multivariate linear regression analyses: P value, coefficient (95% confidence interval)

From: Left atrial dysfunction can independently predict exercise capacity in patients with chronic heart failure who use beta-blockers

 

LA reservoir strain

LA conduit strain

LA booster strain

LAVImax

LAVImin

Univariate

 < 0.0001;0.23 (0.13 to 0.33)

0.019; 0.18 (0.03 to 0.32)

0.001; 0.25 (0.10 to 0.41)

 < 0.0001;  − 0.13 ( − 0.17 to  − 0.08)

 < 0.0001;  − 0.16 ( − 0.22 to  − 0.10)

Model 1

 < 0.0001;0.19 (0.09 to 0.28)

0.004; 0.19 (0.06 to 0.32)

0.032; 0.16 (0.010 to 0.31)

 < 0.0001;  − 0.10 ( − 0.15 to  − 0.05)

 < 0.0001;  − 0.13 ( − 0.19 to  − 0.07)

Model 2

0.001; 0.19 (0.08 to 0.29)

0.140;  − 0.143 ( − 0.28 to  − 0.00)

0.015;  − 0.18 ( − 0.33 to  − 0.04)

 < 0.0001;  − 0.10 ( − 0.16 to  − 0.05)

 < 0.0001;  − 0.13 ( − 0.21 to  − 0.06)

Model 3

0.003; 0.18 (0.07 to 0.29)

0.114;  − 0.12 ( − 0.28 to 0.03)

0.021;  − 0.19 ( − 0.35 to  − 0.03)

0.002;  − 0.10 ( − 0.15 to  − 0.04)

0.003;  − 0.11 ( − 0.19 to  − 0.04)

  1. Model 1: adjusted for age, sex, and BMI. Model 2: adjusted for NT-proBNP, hemoglobin and GFR. Model 3: adjusted for left ventricular ejection fraction, E/e' and TAPSE
  2. LA, left atrial; LAVImax, maximum left atrial volume index; LAVImin, minimum left atrial volume index; BMI, body mass index; NT-proBNP, N-terminal pro-brain natriuretic peptide; GFR, glomerular filtration rate; E/e′, ratio of transmitral E velocity to tissue Doppler mitral annulus e′ velocity; TAPSE, tricuspid annular plane systolic excursion