| Total | ESC strategy | p | CACS-CL strategy | p | ||
---|---|---|---|---|---|---|---|
High risk | Low risk | High risk | Low risk | ||||
n = 5289 | n = 2962 | n = 2327 | n = 2247 | n = 3042 | |||
Age (years, mean ± SD) | 56.1 ± 10.3 | 58.1 ± 10.4 | 53.6 ± 10.6 |  < 0.0001 | 58.6 ± 10.5 | 54.3 ± 10.4 |  < 0.0001 |
Male | 2697 (51) | 1807 (61) | 890 (38) |  < 0.0001 | 1303 (58) | 1394 (46) |  < 0.0001 |
Diabetes | 1005 (19) | 652 (22) | 353 (15) |  < 0.0001 | 562 (25) | 443 (14) |  < 0.0001 |
Hypertension | 2169 (41) | 1303 (44) | 866 (37) |  < 0.0001 | 1011 (45) | 1158 (38) |  < 0.0001 |
Hyperlipidemia | 1798 (34) | 1155 (39) | 643 (28) |  < 0.0001 | 854 (38) | 944 (31) |  < 0.0001 |
Smoking | 1534 (29) | 948 (32) | 586 (25) |  < 0.0001 | 742 (33) | 792 (26) |  < 0.0001 |
Family history | 1904 (36) | 1214 (41) | 690 (30) |  < 0.0001 | 989 (44) | 915 (30) |  < 0.0001 |
Symptom |  |  |  |  < 0.0001 |  |  |  < 0.0001 |
 Nonanginal chest pain | 2010 (38) | 918 (31) | 1092 (47) |  | 742 (33) | 1268 (42) |  |
 Atypical angina | 2380 (45) | 1392 (47) | 988 (42) |  | 989 (44) | 1391 (46) |  |
 Typical angina | 899 (17) | 652 (22) | 247 (11) |  | 516 (23) | 383 (12) |  |
CACS (median, 25th–75th) | 4 (0–75) | 55 (0–389) | 0 (0–37) |  < 0.0001 | 62 (0–401) | 0 (0–31) |  < 0.0001 |
CAD |  |  |  |  < 0.0001 |  |  |  < 0.0001 |
 No CAD | 2644 (50) | 1118 (38) | 1526 (65) |  | 559 (25) | 2085 (69) |  |
 Nonobstructive CAD | 1640 (31) | 992 (33) | 648 (28) |  | 817 (36) | 823 (27) |  |
 Obstructive CADa | 1005 (19) | 852 (29) | 153 (7) |  | 871 (39) | 134 (4) |  |
MACE | 211 (4) | 177 (6) | 34 (1) |  < 0.0001 | 185 (8) | 26 (1) |  < 0.0001 |