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Table 3 Baseline characteristics, CAD and MACE by risk groups based on two strategies

From: Comparison of risk assessment strategies incorporating coronary artery calcium score with estimation of pretest probability to defer cardiovascular testing in patients with stable chest pain

 

Total

ESC strategy

p

CACS-CL strategy

p

High risk

Low risk

High risk

Low risk

n = 5289

n = 2962

n = 2327

n = 2247

n = 3042

Age (years, mean ± SD)

56.1 ± 10.3

58.1 ± 10.4

53.6 ± 10.6

 < 0.0001

58.6 ± 10.5

54.3 ± 10.4

 < 0.0001

Male

2697 (51)

1807 (61)

890 (38)

 < 0.0001

1303 (58)

1394 (46)

 < 0.0001

Diabetes

1005 (19)

652 (22)

353 (15)

 < 0.0001

562 (25)

443 (14)

 < 0.0001

Hypertension

2169 (41)

1303 (44)

866 (37)

 < 0.0001

1011 (45)

1158 (38)

 < 0.0001

Hyperlipidemia

1798 (34)

1155 (39)

643 (28)

 < 0.0001

854 (38)

944 (31)

 < 0.0001

Smoking

1534 (29)

948 (32)

586 (25)

 < 0.0001

742 (33)

792 (26)

 < 0.0001

Family history

1904 (36)

1214 (41)

690 (30)

 < 0.0001

989 (44)

915 (30)

 < 0.0001

Symptom

   

 < 0.0001

  

 < 0.0001

 Nonanginal chest pain

2010 (38)

918 (31)

1092 (47)

 

742 (33)

1268 (42)

 

 Atypical angina

2380 (45)

1392 (47)

988 (42)

 

989 (44)

1391 (46)

 

 Typical angina

899 (17)

652 (22)

247 (11)

 

516 (23)

383 (12)

 

CACS (median, 25th–75th)

4 (0–75)

55 (0–389)

0 (0–37)

 < 0.0001

62 (0–401)

0 (0–31)

 < 0.0001

CAD

   

 < 0.0001

  

 < 0.0001

 No CAD

2644 (50)

1118 (38)

1526 (65)

 

559 (25)

2085 (69)

 

 Nonobstructive CAD

1640 (31)

992 (33)

648 (28)

 

817 (36)

823 (27)

 

 Obstructive CADa

1005 (19)

852 (29)

153 (7)

 

871 (39)

134 (4)

 

MACE

211 (4)

177 (6)

34 (1)

 < 0.0001

185 (8)

26 (1)

 < 0.0001

  1. Values are presented as n (%) unless stated otherwise
  2. ESC strategy 2019 European Society of Cardiology guideline-determined risk assessment strategy, CACS coronary artery calcium score, CACS-CL strategy CACS-weighted clinical likelihood model-based risk assessment strategy, CAD coronary artery disease, MACE major adverse cardiovascular event
  3. aObstructive CAD was defined as an individual had at least one lesion with ≥ 50% diameter stenosis or any non-assessable segments because of severe calcification on CCTA