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Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: Hyperuricemia exacerbates abdominal aortic aneurysm formation through the URAT1/ERK/MMP-9 signaling pathway

Fig. 5

Soluble uric acid stimulates p-ERK1/2 and MMP9 production through URAT1 in HASMCs. A Protein abundance in cells that were stimulated or not stimulated with uric acid and transfected with siURAT1. B MMP-9 protein expression abundance. C URAT1 protein abundance. D p-ERK1/2 protein abundance. E Protein abundance in cells stimulated or not stimulated with uric acid, PD98059 or NAC. F MMP-9 protein expression abundance. G p-ERK protein abundance. H Fold changes in the relative mRNA expression of URAT1 between the uric acid-treated group and the control group. The Ct value of URAT1 obtained by RT–PCR and that of the internal control. p-ERK1/2: phospho-extracellular signal-regulated kinase 1/2; MMP: matrix metalloproteinase; URAT1: urate transporter 1; HASMCs: human aortic smooth muscle cells; NAC: N-acetylcysteine. The upper and lower whiskers show the maximal and minimal values, respectively, and the upper, middle and lower horizontal lines in the box represent the upper, middle and lower quartiles, respectively. Original images of blots (Additional file 1). *P < 0.05

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