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Table 3 Distribution genotypes and allele frequencies and the candidate SNPs between CR and non-CR patients

From: Influence of genetic polymorphisms in P2Y12 receptor signaling pathway on antiplatelet response to clopidogrel in coronary heart disease

Gene/SNP

Genotype

Non-CR

CR

Co-dominat

P value

Dominant

P value

Recessive

P value

CYP2C19*2

No. of patients with data

90

149

0.020

0.031

0.000

 

*1/*1, n (%)

52 (57.8)

64 (43.0)

 

*1/*2, n (%)

37 (41.1)

74 (49.7)

 

*2/*2, n (%)

1 (1.1)

11 (7.4)

CYP2C19*3

No. of patients with data

87

144

0.227

N/A

0.227

 

*1/*1, n (%)

81 (93.1)

127 (88.2)

 

*1/*3, n (%)

6 (6.9)

17 (11.8)

CYP2C19*2*3

No. of patients with data

87

144

0.072

N/A

0.072

 

*1/*1, n (%)

46 (52.9)

53 (36.8)

 

*1/*2 + *1/*3, n (%)

7 (8.0)

2 (1.4)

 

*2/*2 + *1/*3, n (%)

0 (0.0)

0 (0.0)

P2RY12 rs2046934

No. of patients with data

87

141

0.945

N/A

0.945

 

GG, n (%)

51 (58.6)

82 (58.2)

 

GA, n (%)

36 (41.4)

59 (41.8)

P2RY12 rs6809699

No. of patients with data

86

141

0.043

0.115

0.021

 

CC, n (%)

76 (88.4)

107 (75.9)

 

CA, n (%)

10 (11.6)

30 (21.3)

 

AA, n (%)

0 (0)

4 (2.8)

PIK3CA rs67562832

No. of patients with data

84

146

0.470

0.629

0.336

 

AA, n (%)

64 (76.2)

119 (81.5)

 

AG, n (%)

19 (22.6)

24 (16.4)

 

GG, n (%)

1 (1.2)

3 (2.1)

PIK3CA rs77576241

No. of patients with data

86

146

0.303

0.442

0.133

 

CC, n (%)

84 (97.7)

136 (93.2)

 

CT, n (%)

2 (2.3)

9 (6.2)

 

TT, n (%)

0 (0)

1 (0.7)

APBB1IP rs11015149

No. of patients with data

86

146

0.024

0.023

0.364

 

CC, n (%)

73 (84.9)

117 (80.1)

 

CA, n (%)

10 (11.6)

29 (19.9)

 

AA, n (%)

3 (3.5)

0 (0)

TLN1 rs2295795

No. of patients with data

85

145

0.326

0.135

0.672

 

GG, n (%)

47 (55.3)

76 (52.4)

 

GA, n (%)

36 (42.4)

59 (40.7)

 

AA, n (%)

2 (2.4)

10 (6.9)

TLN1 rs10814270

No. of patients with data

85

147

0.422

0.346

0.241

 

CC, n (%)

21 (24.7)

47 (32.0)

 

CT, n (%)

44 (51.8)

73 (49.7)

 

TT, n (%)

20 (23.5)

27 (18.4)

ITGB3 rs3785873

No. of patients with data

85

145

0.236

0.634

0.090

 

GG, n (%)

61 (71.8)

88 (60.7)

 

GA, n (%)

20 (23.5)

48 (33.1)

 

AA, n (%)

4 (4.7)

9 (6.2)

ITGB3 rs58847127

No. of patients with data

86

145

0.363

0.440

0.291

 

GG, n (%)

71 (82.6)

127 (87.6)

 

GC, n (%)

15 (17.4)

17 (11.7)

 

CC, n (%)

0 (0)

1 (0.4)

ITGA2B rs3760364

No. of patients with data

86

144

0.853

N/A

0.853

 

TT (%)

80 (93)

133 (92.4)

 

TA (%)

6 (7)

11 (7.6)

RASGRP2 rs2230414

No. of patients with data

86

143

0.642

0.716

0.478

 

CC, n (%)

39 (45.3)

58 (40.6)

 

CA, n (%)

36 (41.9)

69 (48.3)

 

AA, n (%)

11 (12.8)

16 (11.2)