Hepatic dysfunction and adverse outcomes after total arch repair of acute type a aortic dissection: application of the MELD-XI score

Table 1 Preoperative data of the two groups

Valuables	MELD-XI < 14 (n = 74)	MELD-XI ≥ 14 (n = 153)	P value
Demographic and baseline risks
Age (years)	51.22 ± 11.79	51.37 ± 10.56	0.923
BMI (kg/m²)	25.04 ± 3.26	25.29 ± 3.16	0.581
Male gender (n, %)	45 (60.8)	87 (56.9)	0.572
Hypertension (n, %)	54 (73.0)	120 (78.4)	0.362
Diabetes mellitus (n, %)	5 (6.8)	7 (4.6)	0.710
Marfan syndrome (n, %)	5 (6.8)	5 (3.3)	0.392
Smoking history (n, %)	36 (48.6)	83 (54.2)	0.428
Drinking history (n, %)	12 (16.2)	27 (17.6)	0.789
Preoperative LVEF (%)	64.73 ± 5.92	63.17 ± 7.44	0.117
Preoperative comorbidities
COPD (n, %)	1 (1.4)	3 (2.0)	1.000
Shock (sbP < 80 mmHg) ^a (n, %)	1 (1.4)	6 (3.9)	0.522
Moderate/severe pericardial effusion ^b (n, %)	1 (1.4)	9 (5.9)	0.225
Myocardial ischaemia^c (n, %)	1 (1.4)	7 (4.5)	0.395
Multi-organ malperfusion ^d (n, %)	0 (0)	1 (0.7)	1.000
Renal insufficiency ^e (n, %)	7 (9.5)	35 (22.9)	0.023
Acute aortic regurgitation (n, %)	20 (27.0)	44 (28.8)	0.786
Involving the celiac trunk ^f (n, %)	4 (5.4)	33 (21.6)	0.002
Involving the renal artery (n, %)	9 (12.2)	25 (16.3)	0.408
Preoperative biochemical data
Leucocytes(10⁹/L)	11.38 ± 3.19	12.36 ± 4.00	0.065
Hemoglobin(g/L)	130.53 ± 18.13	130.88 ± 19.71	0.898
Albumin (g/L)	39.10 ± 8.45	37.13 ± 5.60	0.038
Total bilirubin(U/L)	15.68 ± 8.50	20.96 ± 20.24	0.033
Alanine transaminase (U/L)	31.34 (14.75,38.00)	119.41 (19.00,57.50)	0.003
Aspartate transaminase (U/L)	45.74 (18.50,33.00)	177.41 (21.00,80.00)	< 0.001
γ-glutamyl transferase (U/L)	39.22 ± 42.93	47.08 ± 49.81	0.246

Data are presented as mean ± standard deviation, median [interquartile range] or number (%). Chi-square test for categorical variables and t test or Wilcoxon rank sum test for continuous variables
Sbp Systolic blood pressure, LVEF Left ventricle ejection fraction, BMI Body mass index, COPD Chronic obstructive pulmonary disease
^aShock:Simply the systolic blood pressure less than 90 mmHg
^bModerate/severe pericardial effusion: intraoperatively confirmed effusion volume exceeding 300 ml and were based on cardiac color ultrasonography, an anechoic area in the left ventricular posterior wall were increased(> 10 mm)
^cMyocardial ischaemia: myocardial ischaemia indicated by the preoperative electrocardiogram, increased myocardial enzymes and segmental wall motion abnormalities revealed by the UCG
^dMulti-organ malperfusion: clinical symptom or evidence of ischaemia involving three or more organs of the heart, brain, spinal, liver, spinal cord, or gastrointestinal tract and extremities
^ePreoperative renal insufficiency: Serum creatinine > 130 mmol/L
^fInvolving the celiac trunk: Preoperative abdominal aortic CTA revealed dissection of the celiac trunk

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