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Table 4 Evidence for interaction beyond additivity regarding the risk for future Acute Myocardial Infarction (AMI)

From: Anxiety and depression symptoms, albuminuria and risk of acute myocardial infarction in the Norwegian HUNT cohort study

 

RERI (95% CI)

AP (95% CI)

S (95%CI)

Imputed models

 ACR yes (ACR > =3) and Depression yes (HADS-D > =8)

0.36 (−0,34, 1.05)

19.3% (−12.8, 51.4%)

1.73 (0.65, 4.65)

 ACR yes (ACR > =3) and Anxiety yes (HADS-A > =8)

−0.37 (− 0,39, − 1.13)

−20.0% (−14.6, −54.7%)

1.77 (0.61, 5.12)

 ACR yes (ACR > =3) and HADS-D or HADS-A > =8

0.32 (− 0,62, 1.68)

18.3% (−11.7, 48.4%)

1.78 (0.62, 2,33)

Complete case

 i) ACR yes (ACR > =3) and Depression yes (HADS-D > =8)

1.01 (− 0.06, 2.08)

44,3% (14.5, 74.0%)

4.75 (0.84, 26.7)

 ii) ACR yes (ACR > =3) and Anxiety yes (HADS-A > =8)

1.48(− 0.98, 1.97)

21.1% (38.4, 68.0%)

5.96 (1.45, 24.5)

 iii) ACR yes (ACR > =3) and HADS-D or HADS-A > =8

1.10 (0.73, 1.13)

49,0% (24.1, 73.9%)

8,85 (0.47, 168.0)

  1. Overview of n, events and person-years in CC:
  2. i) Albumine Creatinine Ratio (ACR, mg/mmol) and HADS-Depression (n = 5660 persons/ 564 cases/ 84,500 person-years)
  3. ii) ACR and HADS-Anxiety (n = 5599/553 cases/ 83,839 person-years)
  4. iii) ACR and HADS- Depression or Anxiety (n = 5607/555cases/ 83,951 person-years)
  5. The results on synergisms are derived from model 3 in Table 2
  6. Abbreviations: ACR Albumine Creatinine Ratio, RERI The Relative Excess Risk, AP Attributable Proportion, S Synergi Index, CI 95% Confidence Intervals