Table 3 Association between single nucleotide polymorphisms and peak and trough plasma concentrations of dabigatran

ABCB1

rs4148738

CC

N = 13

46.20 ± 31.10

 N = 10

82.30 ± 58.66

CT

N = 45

48.80 ± 42.93

 N = 26

97.33 ± 60.65

TT

N = 25

58.52 ± 34.93

 N = 22

114.16 ± 50.35

P value

0.535

0.310

rs2032582

AT

N = 17

43.12 ± 34.16

 N = 6

87.89 ± 54.86

CC

N = 11

45.95 ± 31.91

 N = 9

109.01 ± 41.55

AA

N = 13

46.20 ± 31.10

 N = 10

82.30 ± 58.66

AC

N = 28

52.26 ± 47.74

 N = 20

100.16 ± 63.34

TT

N = 4

65.23 ± 34.14

 N = 3

154.06 ± 74.07

CT

N = 10

69.66 ± 37.17

 N = 10

106.83 ± 50.45

P value

0.568

0.520

rs1045642

AA

N = 13

43.01 ± 32.90

 N = 11

75.55 ± 59.19

AG

N = 41

51.24 ± 44.78

 N = 23

99.44 ± 51.85

GG

N = 29

55.17 ± 32.39

 N = 24

114.45 ± 58.29

P value

0.650

0.169

CES1

rs2244613

GG

N = 32

44.21 ± 30.20

 N = 20

89.16 ± 57.00

GT

N = 37

58.03 ± 45.72

 N = 28

113.09 ± 58.86

TT

N = 14

49.86 ± 36.21

 N = 10

91.54 ± 48.04

P value

0.338

0.304

rs8192935

AA

N = 45

42.73 ± 29.04

 N = 31

89.58 ± 54.35

AG

N = 36

58.66 ± 45.46

 N = 25

112.23 ± 58.03

GG

N = 2

112.69 ± 40.63

 N = 2

141.08 ± 63.29

P value

0.013^*

0.202