Table 2 List of selected endomiRs
MiRNA | Target protein | Pathophysiological effect |
|---|---|---|
miR-10a (24)↓ miR-146a (25) ↓ miR-185 (26) ↑ | NFκB ↑ NOX-4 ↑ GPx-1 ↓ | Increased oxidative stress Increased oxidative stress Increased oxidative stress |
miR-92a (27) ↓ miR-125a-5p a (28) ↑ miR-217 (29) ↑ | TNF-α-receptor 1 ↑ eNOS ↓ SIRT-1 ↓ | Reduced nitric oxide availability Reduced nitric oxide availability Reduced nitric oxide availability |
miR-19a (30) ↑ miR-21 (31) ↑ miR-100 (32) ↑ | cyclin D1 ↓ β–galactosidase ↑ NrF-2 ↓ | Accelerated cellular senescence Accelerated cellular senescence Accelerated cellular senescence |
miR-34a (33) ↑ miR-124 (35) ↓ miR-199a-5p (34) ↑ | SIRT-1 ↓ PTBP1 ↑ AMPK ↓ | Dysregulated energy metabolism Dysregulated energy metabolism Dysregulated energy metabolism |
miR-126 (36) ↓ miR-155 (37) ↓ miR-205 (38) ↑ | VCAM-1 ↑ AT1 receptor ↑ TIMP-3 ↓ | Increased chronic inflammation Increased chronic inflammation Increased chronic inflammation |