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Table 4 Independent predictors of all-cause death

From: The predictive effect of direct-indirect bilirubin ratio on clinical events in acute coronary syndrome: results from an observational cohort study in north China

 

Univariate

Multivariate

HR (95%CI)

p value

Adjusted HR (95%CI)

p value

Total bilirubin, umol/L

1.011 (0.997, 1.025)

0.132

  

Direct bilirubin, umol/L

1.109 (1.079, 1.140)

<0.001

1.069 (1.035, 1.103)

< 0.001

Indirect bilirubin, umol/L

0.996 (0.976, 1.015)

0.650

  

Direct/indirect bilirubin ratio

3.339 (2.352, 4.739)

<0.001

2.652 (1.577, 4.461)

<0.001

Age, years

1.088 (1.078, 1.099)

<0.001

1.056 (1.042, 1.070)

<0.001

Male gender

1.161 (0.967, 1.393)

0.110

  

BMI, kg/m2

0.936 (0.911, 0.961)

<0.001

0.966 (0.938, 0.995)

0.023

SBP, mmHg

1.009 (1.004, 1.014)

<0.001

1.007 (1.001, 1.013 )

0.027

DBP, mmHg

0.987 (0.979, 0.995)

0.002

0.993 (0.982, 1.004)

0.225

Heart rate, bpm

1.024 (1.019, 1.030)

<0.001

1.014 (1.007, 1.020)

<0.001

Medical history

    
 

Current/ex-Smoker

1.031 (0.864, 1.231)

0.732

  
 

Hypertension

1.391 (1.132, 1.710)

0.002

1.047 (0.817, 1.342)

0.716

 

Diabetes

1.412 (1.182, 1.686)

<0.001

0.878 (0.685, 1.125)

0.304

 

Dyslipidemia

0.854 (0.714, 1.021)

0.084

  
 

Previous Stroke

2.170 (1.777, 2.649)

<0.001

1.427 (1.139, 1.788)

0.002

 

Previous MI

1.970 (1.575, 2.464)

<0.001

1.215 (0.899, 1.641)

0.206

 

Past PCI

1.380 (1.110, 1.716)

0.004

1.199 (0.900, 1.596)

0.215

 

Past CABG

2.153 (1.404, 3.301)

<0.001

1.389 (0.842, 2.291)

0.199

Medication on admission

    
 

Antiplatelet agent

1.033 (0.863, 1.237)

0.722

  
 

ACEI/ARB

1.060 (0.882, 1.274)

0.536

  
 

Beta-blocker

0.783 (0.625, 0.980)

0.033

0.865 (0.663, 1.128)

0.284

 

Statins

0.699 (0.568, 0.862)

0.001

0.789 (0.615, 1.013)

0.063

Laboratory data

    
 

WBC, 109/L

1.047 (1.011, 1.084)

0.010

1.038 (0.995, 1.083)

0.085

 

Hemoglobin, g/L

0.988 (0.985, 0.991)

<0.001

0.995 (0.990, 1.000)

0.032

 

HsCRP, mg/L

1.033 (1.026, 1.041)

<0.001

  
 

RBG at admission, mmol/L

1.062 (1.041, 1.084)

<0.001

  
 

FPG, mmol/L

1.104 (1.071, 1.139)

<0.001

  
 

HbA1c, %

1.176 (1.111, 1.243)

<0.001

1.169 (1.085, 1.260)

<0.001

 

Albumin, g/L

0.858 (0.839, 0.877)

<0.001

0.970 (0.943, 0.998)

0.034

 

ALT, U/L

0.988 (0.982, 0.995)

0.001

0.990 (0.983, 0.998)

0.009

 

AST, U/L

1.001 (1.001, 1.002)

0.086

  
 

ALP, U/L

1.008 (1.004, 1.011)

<0.001

  
 

GGT, U/L

1.002 (1.000, 1.004)

0.054

  
 

ChE,

0.685 (0.647, 0.725)

<0.001

  
 

Creatinine, umol/L

1.025 (1.021, 1.029)

<0.001

  
 

eGFR, ml/min/1.73m2

0.961 (0.957, 0.966)

<0.001

0.988 (0.981, 0.994)

<0.001

 

TC, mmol/L

0.910 (0.833, 0.994)

0.037

0.976 (0.870, 1.094)

0.674

 

TGs, mmol/L

0.720 (0.639, 0.811)

<0.001

0.924 (0.813, 1.050)

0.224

 

LDLC, mmol/L

0.943 (0.837, 1.063)

0.337

  
 

HDLC, mmol/L

0.783 (0.558, 1.098)

0.156

  

Echocardiography

    
 

LVEF

0.005 (0.003, 0.011)

<0.001

0.034 (0.013, 0.091)

<0.001

Angiography findings

    
 

LM/three-vessel

2.936 (2.284, 3.774)

<0.001

1.666 (1.248, 2.224)

0.001

 

Proximal LAD

1.411 (1.172, 1.700)

<0.001

1.026 (0.832, 1.265)

0.813

 

PCI/CABG

1.049 (0.876, 1.258)

0.601

  

Medication during hospitalization

    
 

Antiplatelet agent

0.634 (0.405, 0.992)

0.046

0.684 (0.394, 1.188)

0.178

 

ACEI/ARB

1.328 (1.105, 1.597)

0.003

0.995 (0.794, 1.245)

0.962

 

Beta-blocker

1.009 (0.831, 1.225)

0.931

  
 

Statins

0.714 (0.537, 0.949)

0.020

0.837 (0.581, 1.205)

0.339

  1. ACEI: angiotensin-converting enzyme inhibitors, ARB: angiotensin receptor blockers, ALT: alanine aminotransferase, AST: aspartate amino transferase, ALP: alkaline phosphatase, BMI: body mass index, CABG: Coronary Artery Bypass Grafting, CRP: c-reactive protein, ChE: Cholinesterase, DBP: diastolic blood pressure, eGFR: estimated glomerular filtration rate, FPG: fast plasma glucose, GGT: gamma glutamyl transpeptidase, HDL-C: high density lipoprotein cholesterol, LDL-C: low density lipoprotein cholesterol, LVEF: left ventricular ejection fraction, MI: myocardial infarction, NSTEMI: non-ST elevated myocardial infarction, PCI: percutaneous coronary intervention, RBG: random blood glucose, SBP: systolic blood pressure, STEMI:ST-elevated myocardial infarction, TC: total cholesterol, TGs: triacylglycerol, UAP: unstable angina pectoris, WBC: white blood cells