Table 3 Association of GRS on cardiometabolic risk factors among obese and overweight female subjects

BMI (Kg/m²)

0.49

0.22 to 0.76

< 0.001

0.42

0.13 to 0.71

0.004

Body composition

WC (cm)

0.86

0.18 to 1.54

0.01

0.81

0.08 to 1.53

0.02 ^a

0.01

WHR (ratio)

0.12

-0.20 to 0.45

0.46

0.004

0.00 to 0.008

0.07 ^a

0.01

BFM (kg)

0.82

0.25 to 1.39

0.005

0.79

0.19 to 1.39

0.01 ^a

0.01

BF (%)

0.44

0.06 to 0.82

0.02

0.49

0.08 to 0.89

0.01 ^a

0.01

BMR (kcal)

-1.49

-10.95 to 7.96

0.75

-4.66

-14.99 to 5.66

0.37 ^a

0.006

BMC (g)

-0.02

-0.44 to 0.005

0.12

-0.02

-0.05 to -0.001

0.04 ^a

0.02

SMM (kg)

-0.01

-0.25 to 0.23

0.92

-0.09

-0.35 to 0.16

0.46 ^a

0.08

Blood pressure

SBP (mmHg)

0.62

-1.20 to 2.44

0.50

-0.21

-2.10 to 1.67

0.82

0.081

DBP (mmHg)

0.20

-1.09 to 1.50

0.75

-0.47

-1.81 to 0.86

0.48

0.071

Blood parameters

FBS (mg/Dl)

0.54

-0.85 to 1.95

0.44

0.26

-1.13 to 1.66

0.71

0.10

Total cholesterol (g/dl)

-3.63

-8.74 to 1.47

0.16

-3.78

-9.09 to 1.53

0.16

0.09

TG (mg/dl)

2.28

-7.68 to 12.25

0.65

1.12

-9.65 to 11.90

0.83

0.07

HDL (mg/dl)

-1.13

-2.66 to 0.40

0.14

-0.42

-2.05 to 1.21

0.61

0.008

LDL (mg/dl)

-2.5

-5.95 to 0.92

0.15

-2.24

-5.81 to 1.31

0.21

0.084

hs-CRP (mg/L)

0.46

0.14 to 0.78

0.005

0.44

0.11 to 0.78

0.009

0.15

HOMA index

0.04

-0.13 to 0.23

0.61

-0.03

-0.22 to 0.16

0.76

0.10

Insulin (mIU/ ml)

0.01

-0.01 to 0.05

0.33

0.01

-0.02 to 0.04

0.45

0.07

MCP-1 (ng/ml)

0.43

-8.21 to 9.07

0.92

0.91

-8.00 to 9.83

0.84

0.009

Galectin3 (ng/ml)

0.09

-0.93 to 1.12

0.85

0.04

-1.17 to 1.26

0.93

0.03

PAI-1 (ng/ml)

-0.68

-3.80 to 2.43

0.66

-2.13

-5.41 to 1.15

0.20

0.06