Table 2 Multivariate regression analysis of the association between CVD risk factors and Plasma Klotho
From: Association between serum klotho levels and cardiovascular disease risk factors in older adults
Plasma klotho (pg/ml) | Total population | Stratification by gender | ||||
|---|---|---|---|---|---|---|
Male | Female | |||||
Beta coefficienta (SE) | p value | Beta coefficienta (SE) | p value | Beta coefficienta (SE) | p value | |
BMI | ||||||
Underweight | 12.798 (26.550) | 0.6298 | − 4.644 (38.501) | 0.9040 | 18.798 (36.491) | 0.6065 |
Normal weight | Reference | Reference | ||||
Overweight | − 22.607 (7.483) | 0.0025 | − 19.077 (10.237) | 0.0624 | − 26.068 (11.322) | 0.0213 |
Obesity | − 23.716 (7.264) | 0.0011 | − 12.607 (10.779) | 0.2422 | − 38.948 (10.506) | 0.0002 |
Exercise | ||||||
Yes | Reference | Reference | ||||
No | − 3.691 (5.549) | 0.5059 | 9.663 (7.370) | 0.1898 | − 16.763 (8.194) | 0.0408 |
Smoking | ||||||
Current smoking | − 46.412 (7.512) | < .0001 | − 34.831 (9.830) | 0.0004 | − 60.661 (11.426) | < .0001 |
Experienced at the past | − 24.207 (6.444) | 0.0002 | − 24.461 (8.338) | 0.0034 | − 26.961 (9.883) | 0.0064 |
None | Reference | Reference | ||||
Alcohol drinking | ||||||
Yes | − 51.194 (6.768) | < .0001 | − 49.196 (10.666) | < .0001 | − 55.834 (8.746) | < .0001 |
No | Reference | Reference | ||||
Hypertension | ||||||
Yes | Reference | Reference | ||||
No | 4.767 (6.550) | 0.4668 | 17.588 (8.430) | 0.037 | − 10.358 (10.095) | 0.3049 |
Dyslipidemia | ||||||
Yes | Reference | Reference | ||||
No | 15.474 (5.546) | 0.0053 | − 4.570 (7.340) | 0.5335 | 37.511 (8.361) | < .0001 |
1-unit increase in lipid profiles (mg/dL) | ||||||
HDL | 0.010 (0.182) | 0.9562 | − 0.654 (0.272) | 0.0162 | 0.499 (0.250) | 0.0461 |
LDL | − 0.055 (0.117) | 0.6409 | 0.069 (0.151) | 0.6469 | − 0.153 (0.176) | 0.3845 |
TG | − 0.117 (0.033) | 0.0006 | 0.052 (0.046) | 0.2559 | − 0.285 (0.077) | 0.0002 |
Total Chol | − 0.249 (0.066) | 0.0002 | − 0.173 (0.087) | 0.0479 | − 0.315 (0.100) | 0.0018 |
1-unit increase in blood Pressure (mm Hg) | ||||||
Systolic blood pressure | − 0.206 (0.158) | 0.1934 | − 0.267 (0.209) | 0.2010 | − 0.113 (0.234) | 0.6276 |
Diastolic blood pressure | − 0.040 (0.287) | 0.8891 | − 0.089 (0.456) | 0.8437 | 0.030 (0.351) | 0.9308 |