Table 1 Basic demographic data of the study population [n (%)] base on liver enzymes
Variables | GGT | ALT | AST | ALP | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Full population | Propensity score matched | Full population | Propensity score matched | Full population | Propensity score matched | Full population | Propensity score matched | ||||||||||||
Un-*** expose | Expose** | Un expose | Expose | Un- expose | Expose | Un- expose | Expose | Un- expose | Expose | Un- expose | Expose | Un- expose | expose | Un- expose | expose | ||||
4939 | 3328 | 1832 | 1832 | 4266 | 4001 | 1852 | 1852 | 4458 | 3809 | 2047 | 2047 | 4555 | 3712 | 2168 | 2168 | ||||
Age* group n (%) | |||||||||||||||||||
35–45 | 2676 (54.2) | 1671 (50.2) | 887 (48.4) | 920 (50.2) | 2149 (50.4) | 2198 (54.9) | 936 (50.5) | 1017 (54.9) | 2364 (53.0) | 1983 (52.1) | 994 (48.6) | 1065 (52.0) | 2601 (57.1) | 1746 (47.0) | 1004 (46.3) | 1020 (47.0) | |||
46–55 | 1481 (30.0) | 1085 (32.6) | 606 (33.1) | 597 (32.6) | 1339 (31.4) | 1227 (30.7) | 611 (33.0) | 568 (30.7) | 1373 (30.8) | 1193 (31.3) | 675 (32.9) | 642 (31.4) | 1360 (29.9) | 1206 (32.5) | 755 (34.8) | 704 (32.5) | |||
56–56 | 782 (15.8) | 572 (17.2) | 339 (18.5) | 315 (17.2) | 778 (18.2) | 576 (14.4) | 305 (16.5) | 267 (14.4) | 721 (16.2) | 633 (16.6) | 378 (18.5) | 340 (16.6) | 594 (13.0) | 760 (20.5) | 409 (18.9) | 444 (20.5) | |||
Gender * | |||||||||||||||||||
Mele | 1857 (37.6) | 2102 (63.2) | 1124 (61.4) | 1157 (63.2) | 1351 (31.7) | 2608 (65.2) | 1167 (63.0) | 1207 (65.2) | 1589 (35.6) | 2370 (62.2) | 1267 (61.9) | 1273 (62.2) | 2058 (45.2) | 1901 (51.2) | 1142 (52.7) | 1110(51.2) | |||
Female | 3082 (62.4) | 1226 (36.8) | 708 (38.6) | 675 (36.8) | 2915 (68.3) | 1393 (34.8) | 685 (37.0) | 645 (34.8) | 2869 (64.4) | 1439 (37.8) | 780 (38.1) | 774 (37.8) | 2497 (54.8) | 1811 (48.8) | 1026 (47.3) | 1058(48.8) | |||
Education Years | |||||||||||||||||||
0 | 1164 (23.6) | 633 (19.0) | 370 (20.2) | 348 (19.0) | 1141 (26.8) | 656 (16.4) | 335 (18.1) | 304 (16.4) | 1003 (22.5) | 794 (20.8) | 400 (19.5) | 427 (20.9) | 863 (18.9) | 934 (25.2) | 487 (22.5) | 545 (25.1) | |||
1–5 | 2028 (41.1) | 1177 (35.4) | 656 (35.8) | 648 (35.4) | 1811 (42.4) | 1394 (34.8) | 662 (35.7) | 645 (34.8) | 1875 (42.1) | 1330 (34.9) | 759 (37.1) | 715 (34.9) | 1853 (40.7) | 1352 (36.4) | 862 (39.8) | 790(36.5) | |||
6–9 | 835 (16.9) | 624 (18.7) | 347 (19.0) | 344 (18.8) | 677 (15.9) | 782 (19.5) | 358 (19.3) | 362 (19.6) | 763 (17.1) | 696 (18.3) | 412 (20.1) | 373 (18.2) | 798 (17.5) | 661 (17.8) | 360 (16.6) | 386 (17.8) | |||
10–12 | 573 (11.6) | 556 (16.7) | 266 (14.5) | 306 (16.7) | 419 (9.8) | 710 (17.8) | 292 (15.8) | 329 (17.8) | 524 (11.7) | 605 (15.9) | 298 (14.6) | 326 (15.9) | 647 (14.2) | 482 (13.0) | 276 (12.7) | 282 (13.0) | |||
13< | 339 (6.8) | 338 (10.2) | 193 (10.5) | 186 (10.1) | 218 (5.1) | 459 (11.5) | 205 (11.1) | 212 (11.4) | 293 (6.6) | 384 (10.1) | 178 (8.7) | 206 (10.1) | 394 (8.7) | 283 (7.6) | 183 (8.4) | 165 (7.6) | |||
Physical Activity METs | |||||||||||||||||||
Low | 1301 (26.3) | 1127 (33.9) | 636 (34.7) | 621 (33.9) | 1123 (26.3) | 1305 (32.6) | 642 (34.7) | 604 (32.6) | 1306 (29.3) | 1122 (29.3) | 621 (30.0) | 603 (29.4) | 1288 (28.3) | 1140 (30.7) | 674 (31.1) | 666 (30.7) | |||
Medium | 2509 (50.8) | 1448 (43.5) | 775 (42.3) | 797 (43.5) | 2237 (52.5) | 1720 (43.0) | 764 (41.2) | 797 (43.0) | 2287 (51.3) | 1670 (43.8) | 863 (42.2) | 898 (43.9) | 2227 (48.9) | 1730 (46.6) | 1003 (46.3) | 1010(46.6) | |||
Intense | 1129 (22.9) | 753 (22.6) | 420 (23.0) | 414 22.6) | 906 (21.2) | 976 (24.4) | 446 (24.1) | 451 (24.1) | 865 (19.4) | 1017 (26.7) | 563 (27.5) | 546 (26.7) | 1040 (22.8) | 842 (22.7) | 491 (22.6) | 492 (22.7) | |||
Alcohol Consumption | |||||||||||||||||||
No | 4761 (96.4) | 3092 (92.2) | 1711 (93.4) | 1702 (92.9) | 4117 (96.5) | 3736 (93.4) | 1736 (93.7) | 1729 (93.4) | 4251 (95.4) | 3602 (94.6) | 1933 (94.4) | 1936 (94.6) | 4355 (95.6) | 3498 (94.2) | 2042 (94.2) | 2043 (94.2) | |||
Yes | 178 (3.6) | 236 (7.1) | 121 (6.6) | 132 (7.1) | 149 (3.5) | 265 (6.6) | 116 (6.3) | 123 (6.6) | 207 (4.6) | 207 (5.4) | 114 (5.6) | 111 (5.4) | 200 (4.4) | 214 (5.8) | 126 (5.8) | 125(5.8) | |||
BMI* | |||||||||||||||||||
18.9> | 166 (3.4) | 40 (1.2) | 22 (1.2) | 24 (1.3) | 169 (4.0) | 37 (0.9) | 34 (1.8) | 17 (0.9) | 113 (2.5) | 93 (2.4) | 57 (2.8) | 50 (2.4) | 128 (2.8) | 78 (2.1) | 41 (1.9) | 46 (2.1) | |||
19-24.9 | 1654 (33.5) | 682 (20.5) | 375 (20.5) | 434 (23.7) | 1427 (33.5) | 909 (22.7) | 464 (40.925.1) | 421 (22.7) | 1228 (27.6) | 1108 (29.1) | 633 (30.9) | 596 (29.1) | 1383 (30.4) | 953 (25.7) | 559 (25.8) | 557(25.7) | |||
25-29.9 | 2014 (40.8) | 1581 (47.5) | 870 (47.5) | 825 (45.0) | 1636 (38.3) | 1959 (49.0) | 817 (44.1) | 906 (49.9) | 1874 (42.0) | 1721 (45.2) | 888 (43.4) | 924 (45.1) | 1927 (42.3) | 1668 (44.9) | 954 (44.0) | 974(44.9) | |||
30.0-34.9 | 866 (17.5) | 818 (24.6) | 450 (24.6) | 382 (20.8) | 799 (18.7) | 885 (22.1) | 396 (21.4) | 98 (5.3) | 952 (21.4) | 732 (19.2) | 364 (17.8) | 394 (19.3) | 889 (19.5) | 795 (21.4) | 475 (21.9) | 464 (21.4) | |||
35.00< | 239 (4.8) | 207 (6.2) | 114 (6.2) | 168 (9.2) | 235 (5.5) | 211 (5.3) | 141 (7.6) | 20 (1.0) | 291 (6.5) | 155 (4.1) | 105 (5.1) | 83 (4.1) | 228 (5.0) | 218 (5.9) | 139 (6.4) | 127 (5.9) | |||
Smoking status | |||||||||||||||||||
Non-smoker | 2142 (43.4) | 1257 (37.8) | 684 (37.3) | 692 (37.8) | 1806 (42.3) | 1593 (39.8) | 657 (35.5) | 738 (39.9) | 1875 (42.1) | 1524 (40.0) | 735 (35.9) | 819 (40.1) | 1977 (43.4) | 1422 (38.3) | 865 (40.0) | 83 (38.3) | |||
recently | 515 (10.4) | 486 (14.6) | 288 (15.7) | 268 (14.6) | 503 (11.8) | 498 (12.5) | 363 (19.6) | 230 (12.4) | 535 (12.0) | 466 (12.2) | 380 (18.6) | 250 (12.2) | 451 (9.9) | 550 (14.8) | 252 (11.6) | 321 (14.8) | |||
history | 316 (6.4) | 331 (9.9) | 175 (9.6) | 182 (9.9) | 263 (6.2) | 384 (9.6) | 167 (9.0) | 178 (9.6) | 300 (6.7) | 347 (9.1) | 200 (9.8) | 187 (9.1) | 342 (7.5) | 305 (8.2) | 210 (9.7) | 178 (8.2) | |||
the past | 1966 (39.8) | 1254 (37.7) | 685 (37.4) | 690 (37.7) | 1694 (39.7) | 526 (38.1) | 665 (35.9) | 706 (38.1) | 1748 (39.2) | 1472 (38.7) | 732 (35.7) | 791 (38.6) | 1785 (39.2) | 1435 (38.7) | 840 (38.7) | 838 (38.7) | |||
DM incidence | |||||||||||||||||||
No | 4864 (98.5) | 3172 (95.3) | 1750 (95.5) | 1746 (95.3) | 4165 (97.6) | 3871 (96.8) | 1769 (95.5) | 1792 (96.8) | 4324 (97.0) | 3712 (97.4) | 1993 (97.4) | 1995 (97.5) | 4459 (97.9) | 3577 (96.4) | 2097 (96.7) | 2089(96.4) | |||
yes | 75 (1.5) | 156 (4.7) | 82 (4.5) | 86 (4.7) | 101 (2.4) | 130 (3.2) | 83 (4.5) | 60 (3.2) | 134 (3.0) | 97 (2.6) | 54 (2.6) | 52 (2.5) | 96 (2.1) | 135 (3.6) | 71 (3.3) | 79 (3.6) | |||
CVD incidence | |||||||||||||||||||
No | 136 (2.7) | 98 (3.1) | 61 (2.9) | 65 (3.1) | 4132 (96.9) | 3902 (97.5) | 1802 (97.3) | 1806 (97.5) | 4324 (97.0) | 3710 (97.4) | 1993 (97.4) | 1994 (97.4) | 4454 (97.8) | 3580 (96.4) | 2097 (96.7) | 2091 (96.4) | |||
yes | 4936 (97.3) | 3097 (96.9) | 2080 (97.1) | 2076 (96.9) | 134 (3.1) | 99 (2.5) | 50 (2.7) | 46 (2.5) | 134 (3.0) | 99 (2.6) | 54 (2.6) | 53 (2.6) | 101 (2.2) | 132 (3.6) | 71 (3.3) | 77 (3.6) | |||
Salt Use | |||||||||||||||||||
Yes | 1397 (28.3) | 937 (28.1) | 488 (26.7) | 516 (28.2) | 1214 (28.5) | 1119 (28.0) | 508 (27.4) | 518 (28.0) | 1269 (28.5) | 1065 (28.0) | 561 (27.4) | 572 (27.9) | 1312 (28.8) | 1022 (27.5) | 592 (27.3) | 597 (27.5) | |||
Sometimes | 1590 (32.2) | 1030 (31.0) | 609 (33.2) | 567 (30.9) | 1352 (31.7) | 1267 (31.7) | 603 (32.6) | 586 (31.6) | 1441 (32.3) | 1179 (30.9) | 660 (32.2) | 634 (31.0) | 1448 (31.8) | 1172(31.6) | 685 (31.6) | 684 (31.6) | |||
No | 1952 (39.5) | 1361 (40.9) | 735 (40.1) | 749 (40.9) | 1696 (39.8) | 1615 (39.8) | 741 (40.0) | 748 (40.4) | 1748 (39.2) | 1565 (41.1) | 826 (40.4) | 841 (41.1) | 1795 (39.4) | 1518 (40.9) | 891 (41.1) | 887 (40.9) | |||
FH1_Hypertension | |||||||||||||||||||
NO | 2557 (51.8) | 1661 (49.9) | 912 (49.8) | 914 (49.9) | 2183 (51.2) | 2035 (50.9) | 930 (50.2) | 942 (50.9) | 2263 (50.8) | 1995 (51.3) | 1034 (50.5) | 1051 (51.3) | 2320 (50.9) | 1898 (51.1) | 1110 (51.2) | 1108 (51.1) | |||
yes | 2382 (48.2) | 1667 (50.1) | 920 (50.2) | 918 (50.1) | 2083 (48.8) | 1966 (49.1) | 922 (49.8) | 910 (49.1) | 2195 (49.2) | 1854 (48.7) | 1013 (49.5) | 996 (48.7) | 2235 (49.1) | 1814 (48.9) | 1058 (48.8) | 1059 (48.9) | |||