DNA methylation alternation in Stanford- A acute aortic dissection

Table 3 Top 10 significant hypomethylated positions in Stanford-A AAD compared to healthy control

CpG site	Gene	Chr	Gene region	Location	△Beta	P values
cg18264728	DAB2	chr5	5’UTR	N_Shelf	-0.528	<0.001
cg24753662	TBX1	chr22	5’UTR	Island	-0.519	<0.001
cg03551963					-0.393	<0.001
cg24531955	LOXL2		3’UTR		-0.327	<0.001
cg04279411					-0.320	<0.001
cg18419977	SLC22A18AS	chr11	Body; TSS1500	N_Shelf	-0.302	<0.001
cg20597486	IFI16		5’UTR; 1stExon		-0.328	<0.001
cg15338782	ATP10A		Body		-0.365	<0.001
cg00903308		chr7		N_Shore	-0.470	<0.001
cg01134144	ARHGEF6		TSS200		-0.315	<0.001

Abbreviations: 5’UTR, 5’-Untranslated region; 3’UTR, 3’-Untranslated region; TSS1500, 1500 bp upstream of transcription start site; TSS200, 200 bp upstream of transcription start site; N-Shelf, North shelf which are regions flanking island; N-Shore, North shore which are regions flanking island; Chr, Chromosome. AAD, Acute aortic dissection

ISSN: 1471-2261