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Table 1 Baseline characteristics of the studied patient population and the single factor analysis as stratified by the prognosis of stroke (n = 403)

From: Elevated NT-proBNP levels are associated with CTP ischemic volume and 90-day functional outcomes in acute ischemic stroke: a retrospective cohort study

Variables

Total population (n = 403)

Functional outcome

x2/t/Z

p-value

Excellent (90-day mRS 0–2) (n = 228)

Poor (90-day mRS 3–6) (n = 175)

Age, median (IQR)—years

67 (56–75)

66.5 (55–73)

69 (60,77)

− 2.851

0.004

Sex—no. (%)

   

2.907

0.088

 Male

256 (63.5)

75 (32.9)

72 (41.1)

  

 Female

147 (36.5)

153 (67.1)

103 (58.9)

  

BMI, mean (SD)—kg/m2

24.48 ± 3.36

24.43 ± 3.57

24.43 ± 3.58

0.254

0.799

SBP, median (IQR)—mmHg

155 (138–175)

154 (137–173)

156 (141–178)

− 0.971

0.332

DBP, median (IQR)—mmHg

88 (78–100)

88 (77.25–99)

89 (78–101)

− 0.538

0.590

Medical history

Atrial Fibrillation—no. (%)

121 (30.0)

52 (22.8)

69 (39.4)

13.019

 < 0.001

Hypertension—no. (%)

269 (66.7)

144 (63.2)

125 (71.4)

3.051

0.081

Diabetes mellitus—no. (%)

99 (24.6)

50 (21.9)

49 (28.0)

1.969

0.161

Family history of stroke—no. (%)

86 (21.3)

51 (22.4)

35 (20.0)

0.331

0.565

Smoking—no. (%)

137 (34.0)

80 (35.1)

57 (32.6)

0.279

0.597

Biochemical variables

TnI, median (IQR)—pg/ml

11.2 (7.42–17.23)

10.765 (7.32–14.64)

12.76 (7.69–21.46)

− 2.577

0.010

D-dimer, median (IQR)—ng/mL

0.36 (0.22–0.81)

0.31 (0.22–0.52)

0.53 (0.26–1.25)

− 5.451

 < 0.001

PLT, mean (SD)—109/L

198.92 ± 58.55

201.45 ± 58.70

195.63 ± 58.35

0.988

0.324

Cr, median (IQR)—mmol/L

66.8 (57.7–79)

67.75 (58.03–79.9)

65.2 (56–78)

− 1.162

0.245

TG, median (IQR)—mmol/L

1.24 (0.91–1.6)

1.28 (0.9–1.74)

1.17 (0.93–1.5)

− 1.610

0.107

TC, median (IQR)—mmol/L

4.3 (3.67–5.04)

4.21 (3.63–5.04)

4.36 (3.7–5.04)

− 1.158

0.247

HDL-C, median (IQR)—mmol/L

1.01 (0.86–1.19)

0.99 (0.84–1.16)

1.04 (0.88–1.21)

− 1.654

0.098

LDL-C, median (IQR)—mmol/L

2.72 (2.11–3.33)

2.7 (2.06–3.33)

2.78 (2.22–3.35)

− 1.076

0.282

HCY, median (IQR)—mmol/L

6 (5.6–7.2)

6 (5.6–6.9)

6.1 (5.5–8)

− 1.004

0.315

NT-proBNP, median (IQR)—100 pg/mL

1.46 (0.5–7.38)

1.02 (0.49–4.56)

3.28 (0.51–10)

− 3.492

 < 0.001

CTP imaging date

CTP ischemic volume (IQR)—mL

34 (0–110)

15.5 (0–58.5)

88 (15–185)

− 7.299

 < 0.001

CTP infarct core volume (IQR)—mL

2 (0–14)

1 (0–6)

10 (1–59)

− 7.961

 < 0.001

CTP ischemic penumbra volume (IQR)—ml

30 (0–84)

13 (0–51)

63 (12–102)

− 6.268

 < 0.001

NIHSS—no. (%)

   

81.372

 < 0.001

 Excellent (0–4)

148 (36.7)

127 (55.7)

21 (12.0)

  

 Poor (5–42)

255 (63.3)

101 (44.3)

154 (88.0)

  

Treatment decisions—no. (%)

   

3.725

0.293

 IV rt-PA

218 (54.1)

132 (57.9)

86 (49.1)

  

 EVT

45 (11.2)

21 (9.2)

24 (13.7)

  

 IV rt-PA + EVT

22 (5.5)

12 (5.3)

10 (5.7)

  

 Standardized treatment

118 (29.3)

63 (27.6)

55 (31.4)

  

TOAST—no. (%)

   

28.356

 < 0.001

 LAA

232 (57.6)

128 (56.1)

104 (59.4)

  

 CE

107 (26.6)

46 (20.2)

61 (34.9)

  

 Other

64 (15.9)

54 (23.7)

10 (5.7)

  
  1. p-value < 0.05 are shown in bold
  2. SBP systolic pressure, DBP diastolic pressure, NIHSS National Institutes of Health Stroke Scale, BMI body mass index p-value, intergroup difference; LAA large-artery atherosclerosis, CE cardioembolic
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BMC Cardiovascular Disorders

ISSN: 1471-2261

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