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Fig. 5 | BMC Cardiovascular Disorders

Fig. 5

From: The synergistic mechanism of fibroblast growth factor 18 and integrin β1 in rat abdominal aortic aneurysm repair

Fig. 5

a Immunohistochemical staining: Itgβ1 was mainly expressed in the intima and media of the aortic wall; Itgβ1 was strongly expressed (+++) in the Sham group; Itgβ1 expression in the AAA + FGF18 and AAA groups was similar; both were weakly positive (+); compared with the AAA group, Itgβ1 expression was significantly higher in the AAA + LV-Itgβ1 and AAA + FGF18 + LV-Itgβ1 groups. Both groups were moderately positive (++). b HE staining: the aortic wall of the Sham group was normal; the structure of the aortic wall in the AAA group was destroyed, and rupturing of the elastic fibers and sparse arrangement were observed; the elastic fibers of the AAA + FGF18 group were not damaged to some extent; the aortic media in the AAA + LV-Itgβ1 + FGF18 group was thinner than that in the Sham group, and the overall structure of the aortic wall was relatively intact. c EVG staining: The structure of the abdominal aortic wall in the Sham group was normal, and the elastic fibers were continuous and regularly corrugated; the elastic fibers of the AAA group were broken and irregularly arranged; AAA + FGF18 group: the elastic fibers increased, and a sparse arrangement and local fractures were osberved; the white tip represents the irregularly arranged elastic fibers; the elastic fibers of the AAA + LV-Itgβ1 group were dense and regularly arranged, but local fractures were observed; the elastic fibers of the AAA + FGF18 + LV-Itgβ1 group were continuous and densely arranged; bar = 500 μm, 100 μm

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