Skip to main content
Fig. 2 | BMC Cardiovascular Disorders

Fig. 2

From: The synergistic mechanism of fibroblast growth factor 18 and integrin β1 in rat abdominal aortic aneurysm repair

Fig. 2

Effects of FGF18 on elastin expression in SMCs. a There was no significant difference in elastin expression between the SMCs treated with 100 ng/mL of FGF18 solution and the SMCs that were not treated with the FGF18 solution (p = 0.163); there was no significant difference in elastin expression between the SMCs treated with 200 ng/mL of FGF18 solution and the SMCs treated with 400 ng/mL of FGF18 solution (p = 0.379). b There was no significant difference in the expression of elastin at different time points after treatment with 100 ng/mL FGF18 solution (p > 0.05). c FGF18 + Itgβ1 can promote the expression of elastin; in the Con group (not treated with FGF18), there was no significant difference in elastin expression amongst the NC, NC + LV-con, NC + LV-Itgβ1-RNAi, and NC + LV-Itgβ1 groups (p > 0.05); there was also no significant difference in elastin expression amongst the NC, NC + LV-Con, and NC + LV-Itgβ1-RNAi groups after FGF18 treatment (p > 0.05); after treatment with FGF18 (100 ng/mL, 24 h), the elastin expression in SMCs in the NC + LV-Itgβ1 group was higher than that in the other three groups (p < 0.05). ***p < 0.001 versus the NC group (treated with FGF18); (d) FGF18 + Itgβ1 promoted the expression of elastic fiber component proteins in SMCs; the expression levels of elastin, fibulin-5, and fibrillin-1 in SMCs in the NC + LV-Itgβ1 group showed a positive relationship with the concentration of the FGF18 solution; The WB gel of a, b, c, and d were cut prior to hybridization with antibodies; **p < 0.05 versus the 0 ng/mL group. ***p < 0.001 versus the 0 ng/mL group

Back to article page