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Table 4 Predictive value of LDH for secondary endpoints

From: Impact of lactate dehydrogenase on prognosis of patients undergoing cardiac surgery

  Unadjusted Adjusted
OR/HR (95% Cl) P OR/HR(95% Cl) P
MIMIC IIIa     
 1-year mortality 2.69 (2.08–3.47) < 0.001 2.08 (1.59–2.73) < 0.001
 Prolonged ventilation 3.86 (3.09–4.81) < 0.001 3.02 (2.38–3.84) < 0.001
 CRRT 2.98 (2.16–4.12) < 0.001 2.84 (1.85–4.36) < 0.001
 ICU stay > 6 days 3.97 (3.24–4.88) < 0.001 3.22 (2.58–4.02) < 0.001
 Hospital stay > 15 days 2.84 (2.32–3.47) < 0.001 2.24 (1.80–2.80) < 0.001
MIMIC IVb     
 1-year mortality 3.27 (1.86–5.76) < 0.001 1.99 (1.05–3.76) 0.034
 Prolonged ventilation 4.50 (3.25–6.23) < 0.001 2.77 (1.90–4.04) < 0.001
 CRRT 3.78 (2.43–5.88) < 0.001 2.92 (1.57–5.40) 0.001
 ICU stay > 6 days 3.55 (2.45–5.15) < 0.001 2.37 (1.55–3.63) < 0.001
 Hospital stay > 15 days 4.98 (3.57–6.93) < 0.001 3.05 (2.09–4.46) < 0.001
  1. The OR/HR was examined regarding the low LDH as reference
  2. OR odds ratio, HR hazard ratio, 95% CI 95% confidence interval, MIMIC Medical Information Mart for Intensive Care, LDH lactate dehydrogenase, ICU intensive care units, CRRT continuous renal replacement therapy
  3. aThe baseline model includes variables that are significant in univariate logistic proportional hazard analysis in MIMIC III, including ethnicity, SBP, heart rate, hypertension, CHD, heart failure, BUN, SCr, sodium, potassium, glucose, SAPS II, SOFA score(details shown in Additional file 2: Table S1)
  4. bThe baseline model includes variables that are significant in univariate logistic proportional hazard analysis in MIMIC IV, including hypertension, heart failure, CKD, WBC, BUN, SCr, sodium, potassium, SAPS II (details shown in Additional file 2: Table S1)