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Fig. 3 | BMC Cardiovascular Disorders

Fig. 3

From: Dynamic regulation of HIF-1 signaling in the rhesus monkey heart after ischemic injury

Fig. 3

Dynamic changes in HIF-1 target genes in the ischemic heart after MI. A Heatmap of 89 significantly changed HIF-1 target genes after ischemic injury, which were segregated into 3 clusters based on their expression patterns using k-means clustering analysis. B Line chart of corresponding clusters. C Top 4 GO terms associated with each cluster. D The expression of mRNA levels determined by RNA-seq and qPCR. qPCR analysis was carried out to examine the expression pattern of two representative genes from each cluster (LDHA and ANGPT2 from cluster 1, LOX and P4HA1 from cluster 2, and VEGFA and SLC2A1 from cluster 3) on the same samples used for RNA-seq. n = 3, * p < 0.05, as determined by one-way ANOVA against the sham group. E Heatmap of normalized enrichment scores (NES) of selected biological processes that were significantly enriched from GSEA. F Heatmap showing the dynamic changes in three subsets of HIF-1 target genes that were significantly enriched in glycolysis, angiogenesis and ECM remodeling

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