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Table 2 Circulating biomarkers of inflammation, fibrosis, and myocyte stretch stratified by HIV serostatus (n = 381)

From: Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV

Biomarker

Median [IQR]

p-valuea

PLWOH (n = 146)

PLWH (n = 235)

sCD14, ng/mL

1424 (1243, 1618)

1662 (1399, 1892)

 < 0.001

IL-6, pg/mL

1.3 (0.8, 2.2)

1.4 (0.9, 2.1)

0.84

Galectin-3, ng/mL

15.3 (12.0, 17.5)

15.1 (12.4, 18.9)

0.13

GDF-15, pg/mL

761 (593, 1003)

1091 (794, 1442)

 < 0.001

TIMP-2, ng/mL

85.9 (77.3, 94.9)

85.7 (77.7, 95.7)

0.93

MMP-2, ng/mL

213 (188, 242)

210 (187, 247)

0.59

NT-proBNP, pg/mL

45.9 (27.6, 79.5)

50.5 (32.4, 110.3)

0.03

hsTnI, ng/mL

2.8 (2.1, 4.9)

3.1 (2.3, 5.1)

0.31

  1. IQR, interquartile range; PLWOH, persons living without HIV; PLWH, persons living with HIV; sCD14, soluble cluster of differentiation 14; IL-6, interleukin-6; GDF-15, growth differentiation factor 15; TIMP-2, tissue inhibitor of metalloproteinase 2; MMP-2, matrix metalloproteinase 2; NT-proBNP, N-terminal prohormone of brain natriuretic peptide; hsTnI, high sensitivity troponin I
  2. aUnadjusted p-values computed using Wilcoxon rank-sum test