The blood microbiome and its association to cardiovascular disease mortality: case-cohort study

Table 3 Prevalence of bacterial genera amongst cases and controls sorted according to total prevalence in the subsample

Genus	Case prevalence (%)	Control prevalence (%)	HR	Confidence interval 95%	p-value
Streptococcus	42.3	58.9	0.54	0.36–0.81	0.003
Staphylococcus	38.3	25.1	1.70	1.09–2.57	0.020
Enhydrobacter*	34.8	13.1	3.30	2.01–5.57	< 0.001
Kocuria*	22.5	3.4	8.50	4.05–17.84	< 0.001
Paracoccus*	5.7	18.3	0.29	0.15–0.57	< 0.001
Stenotrophomonas	7.5	13.7	0.48	0.25–0.92	0.028
Veillonella	4.9	12.0	0.32	0.15–0.68	0.003
Bacteroides	2.6	10.9	0.24	0.09–0.63	0.004

Hazard ratios for cardiovascular disease mortality by Cox proportional hazard regression univariate analyses are presented with accompanying confidence intervals and p-values for the bacteria found to be significant at the 2% cut-off point. Each genus must be present in at least five cases and five controls as well as over five per cent total prevalence to be included in the analyses
*The bacterial genus is also significant when considering the Bonferroni correction

ISSN: 1471-2261