Fig. 1

The EV-profiling led to the discovery of miR-224-5p and 222-3p in the low CFR group. a demonstrates the volcano plot describing the relevance of the miRs with respect to p-value and relative fold change. b, c are representative graphs of the most highly expressed miRs in the respective groups with miR-224-5p and miR-222-3p highly expressed only in the Low CFR group and not among the highest expressed miRNA in the High CFR group. Whereas the d is a comparative graph of the significant increase of the miR-224-5p in the Low CFR group through a Mann–Whitney plot