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Table 1 Case information of the cover-disc in 11 dogs without concavity revealed by TEE

From: The healing response of LAMax LAAC™ left atrial appendage occluder in a canine model: the potential influence of the implantation technique on the healing response

Group

Case No

Device model*

LAA orifice covered by cover-disc monitored by TEE

Peri-device flow CDFI Post-LAAC (mm)

Neo-intimal coverage of LAA occluder’s atrial-surface inspected by gross examination

    

 < 24 h

1 m

2 m

3 m

 

1 month

8

1824

Partially, gap

0

0

Partially, except area at 60° near MA

9

2430

Partially, gap

0

0

Partially, except area at 120° near MA

11

1824

Partially, Over the orifice

5

0

Partially, anchor part blocked LAA orifice, none detectable hole was found from LA to LAA

2 months

14

1824

Partially, gap

2

0

0

Partially, except the area at 0° near MA, none detectable hole was found from LA to LAA

3 months

18

1824

Partially, pushed MA

0

0

0

0

Fully, MA compression by cover-plate with granulation tissue

19

2127

Partially, over the orifice

0

0

0

0

Partially, anchor part blocked small lobe, none detectable hole was found from LA to LAA

21

1824

Partially, gap

2

2

2

2

Fully, the left edge of cover-plate inside LAA, an irregular fissure along the cover plate's edge was found and passed with an 18-gauge hypodermic needle from LA to LAA

23

2127

Partially,Over the orifice

3

3

0

0

Partially, anchor part blocked LAA orifice, none detectable hole was found from LA to LAA

24

1824

Partially, large gap

2

2

2

2

Fully, left edge of cover-plate inside LAA, an irregular hole was found from LA to LAA and passed with an 18-gauge hypodermic needle

6 months

25

2133#

Partially, pushed MA

0

0

0

0

Fully, MA compression with granulation tissue, pulmonary venous partial obstruction

27

2430

Partially, pushed MA

0

0

0

0

Fully, MA compression with granulation tissue

  1. *, the first two digits of LAMax device model are the diameter of anchor part, while the last two digits are the diameter of the cover-plate part; #, LAMax plus device with a special-designed cover-plate with 12 mm larger in diameter than the anchor; LAA, left atrial appendage; MA, mitral annulus