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Fig. 4 | BMC Cardiovascular Disorders

Fig. 4

From: Agonist-induced Piezo1 activation promote mitochondrial-dependent apoptosis in vascular smooth muscle cells

Fig. 4Fig. 4

Piezo1 induces mitochondrial-dependent VSMCs apoptosis via Ca2+ overload and ROS accumulation. (A, B) The fraction of apoptotic cells was assessed. (C, D) The MMP of VSMCs was assessed. (E–H) Western blot analysis of apoptotic related proteins expression level. (I–L) Western blot analysis of related proteins expression level. BAPTA-AM (10 μM), NAC (40 mM). *P < 0.05 and **P < 0.01 vsersus Control. #P < 0.05 and ##P < 0.01 vs. cell treated with Yoda1(30 μM) alone

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