Skip to main content

Table 5 Selected miRNAs under study involved in CAD pathogenesis with their predictive/ validated function and biomarker type

From: Identification of a circulating microRNAs biomarker panel for non-invasive diagnosis of coronary artery disease: case–control study

MiRNA Predictive/ validated function Biomarker References
MiR-21 Share in the proinflammatory processes in the vascular endothelium,
Promotes atherosclerosis
Diagnosis
Severity
Fleissner et al., Zhou et al. and Weber et al., [31, 33, 60]
MiR-126 Increase EC proliferation,
Protects against atherosclerosis
Prognostic
Diagnosis
Severity
Kuhnert et al., and Urbich et al. [38, 46]
MiR-133a Promotes myogenesis,
Cardiac conductance,
Controls collagen synthesis and fibrosis
Diagnosis
Prognostic
Severity
Ahlin et al., Liu et al. and Laffont et al. [89,90,91]
MiR-135b Positive regulation of blood vessel endothelial cell migration, and proliferation Prognostic
Treatment Prediction
Maiti et al., Potthoff et al. and Lin et al. [39, 41, 42]
MiR-140 Negative regulation of NF-kappaB activity, and interleukin-6 production Diagnosis
Prognostic
Werner et al. and Taurino et al. [84, 92]
MiR-145 Increases collagen in the plaque,
Increase stability of the plaque,
Protects against atherosclerosis
Severity
Diagnosis
Cordes et al. and Wei et al. [93, 94]
MiR-146a Inhibits lipid accumulation,
Decrease inflammatory response,
Prevents atherosclerosis
Prognostic
Severity
Taganov et al. and Yang et al. [95, 96]
MiR-155 Increases inflammation,
Increases atherosclerosis
Severity
Diagnosis
Nazari-Jahantigh et al., Wei et al. Androulidaki et al., and Du et al. [61, 62, 97, 98]
MiR-182 Affected by angiogenesis causing modulation in the myocardial response Diagnosis
Treatment Prediction
Zhu et al., and Li et al. [51, 99]
MiR-196b Modulates the cardiomyocyte hypertrophy,
Associated with peripheral arterial disease
Prognostic
Treatment Prediction
Stather et al. and Wu et al. [100, 101]
MiR-200b Promotes endothelial cell apoptosis
Regulation of myotube differentiation and angiogenesis
Prognostic
Treatment Prediction
Zhang et al. [102]
MiR-205 Regulating oxidative stress, mitochondrial function, and apoptosis thus affecting cardiac ischemia/ reperfusion injury Prognostic
Treatment Prediction
Xu et al. [52]
MiR-208a Has a role in cardiac development,
Regulate cardiac myosin heavy chain expression
Severity
Diagnosis
Chistiakov et al. [103]
MiR-223 Affects inflammation in endothelial cells,
Increases atherosclerosis
Prognostic Vickers et al. and Tabet et al. [56, 57]