Skip to main content

Table 2 Distribution of SNPs of PCSK9 gene in T2DM patients and control subjects

From: Association of genetic polymorphisms of PCSK9 with type 2 diabetes in Uygur Chinese population

Genotype Model   Case (n, %) Control (n, %) χ2 P value
rs11583680 Codominant CC 534 (80.7) 977 (80.1) 0.166 0.920
   CT 119 (18.0) 224 (18.4)   
   TT 9 (1.4) 19 (1.6)   
  Dominant CC 534 (80.7) 977 (80.1) 0.092 0.762
   CT + TT 128 (19.3) 243 (19.9)   
  Recessive CC + CT 653 (98.6) 1201 (98.4) 0.115 0.735
   TT 9 (1.4) 19 (1.6)   
  Overdominant CC + TT 543 (82.0) 996 (81.6) 0.043 0.836
   CT 119 (18.0) 224 (18.4)   
rs2483205 Codominant CC 357 (53.9) 583 (47.8) 6.523 0.038
   CT 257 (38.8) 533 (43.7)   
   TT 48 (7.3) 104 (8.5)   
  Dominant CC 357 (53.9) 583 (47.8) 6.473 0.011
   CT + TT 305 (46.1) 637 (52.2)   
  Recessive CC + CT 614 (92.7) 1116 (91.5) 0.938 0.333
   TT 48 (7.3) 104 (8.5)   
  Overdominant CC + TT 405 (61.2) 687 (56.3) 4.173 0.041
   CT 257 (38.8) 533 (43.7)   
rs2495477 Codominant AA 340 (51.4) 560 (45.9) 5.334 0.069
   GA 274 (41.4) 554 (45.4)   
   GG 48 (7.3) 106 (8.7)   
  Dominant AA 340 (51.4) 560 (45.9) 5.123 0.024
   GA + GG 322 (48.6) 660 (54.1)   
  Recessive AA + GA 614 (92.7) 1114 (91.3) 1.181 0.277
   GG 48 (7.3) 106 (8.7)   
  Overdominant AA + GG 388 (58.6) 666 (54.6) 2.815 0.093
   GA 274 (41.4) 554 (45.4)   
rs562556 Codominant AA 613 (92.6) 1097 (89.9) 3.744 0.154
   GA 48 (7.3) 121 (9.9)   
   GG 1 (0.2) 2 (0.2)   
  Dominant AA 613 (92.6) 1097 (89.9) 3.712 0.054
   GA + GG 49 (7.4) 123 (10.1)   
  Recessive AA + GA 661 (99.8) 1218 (99.8) 0.004 0.947
   GG 1 (0.2) 2 (0.2)   
  Overdominant AA + GG 614 (92.7) 1099 (90.1) 3.735 0.053
   GA 48 (7.3) 121 (9.9)   
  1. Note: The bold indicates statistical difference between the two groups and P < 0.05