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Table 1 Major indicators for differential diagnosis between RCM and CP

From: Clinical genetic testing in four highly suspected pediatric restrictive cardiomyopathy cases

 

RCM

CP

Pericardial calcification (TTE, Chest X-ray, CT, MRI)

Rare

 + 

Thickened pericardium (TTE, Chest X-ray, CT, MRI)

0

 + 

Thickened endocardium (TTE, CT, MRI)

Sometimes

0

Abrupt septal movement (‘notch’ or ‘bounce’) in early diastole (TTE)

0

 + 

Septal movement toward left ventricle in inspiration (TTE)

0

 + 

Left and right atrial enlargement (TTE, CT, MRI)

 + 

 + 

the tissue velocity of mitral annulus (TTE)

 < 8 cm/s

 > 8 cm/s

systolic area index (Cardiac catheterization)

0.92 ± 0.19

1.4 ± 0.2

End-diastolic pressure difference between left and right ventricles (Cardiac catheterization)

 > 5 mmHg

 < 5 mmHg

the ratio of right ventricular end-diastolic pressure to systolic pressure (Cardiac catheterization)

0.35 ± 0.14

0.50 ± 0.13

Radionuclide retention in atrium, Delayed radionuclide imaging of right ventricle (Radionuclide examination)

 + 

0

myocardial interstitial fibrosis (Endomyocardial biopsy)

 + 

Rare

B-type natriuretic peptide

Can be higher than 800 pg/ml

Most between 100 ~ 200 pg/ml

  1. RCM restrictive cardiomyopathy, CP constrictive pericarditis, CT computed tomography, MRI magnetic resonance imaging, TTE transthoracic echocardiography