Events | Events rate | Crude model | Model 1a | Model 2b | Model 3c | |
---|---|---|---|---|---|---|
N | Person-year | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | |
Myocardial infarction | ||||||
 LDL-C < 130, hs-CRP < 3 | 16 | 7644.7 | 1 | 1 | 1 | 1 |
 LDL-C < 130, hs-CRP ≥ 3 | 31 | 9429.8 | 1.44 (0.80, 2.60) | 1.35 (0.77, 2.36) | 1.62 (0.88, 2.99) | 1.67 (0.90, 3.09) |
 LDL-C ≥ 130, hs-CRP < 3 | 25 | 8129.7 | 1.19 (0.59, 2.43) | 1.05 (0.54, 2.05) | 1.35 (0.71, 2.55) | 1.37 (0.72, 2.61) |
 LDL-C ≥ 130, hs-CRP ≥ 3 | 30 | 7917.6 | 1.41 (0.73, 2.73) | 1.30 (0.70, 2.42) | 1.72 (0.93, 3.20) | 1.71 (0.91, 3.19) |
Ischemic heart disease | ||||||
 LDL-C < 130, hs-CRP < 3 | 66 | 7644.7 | 1 | 1 | 1 | 1 |
 LDL-C < 130, hs-CRP ≥ 3 | 83 | 9429.8 | 1.33 (0.98, 1.82) | 1.22 (0.84, 1.76) | 1.14 (0.81, 1.60) | 1.15 (0.81, 1.63) |
 LDL-C ≥ 130, hs-CRP < 3 | 101 | 8129.7 | 1.26 (0.88, 1.79) | 1.07 (0.70, 1.63) | 1.30 (0.93, 1.81) | 1.29 (0.92, 1.81) |
 LDL-C ≥ 130, hs-CRP ≥ 3 | 105 | 7917.6 | 1.42 (1.02, 1.97) | 1.24 (0.83, 1.84) | 1.50 (1.08, 2.08) | 1.44 (1.03, 2.02) |
Stroke | ||||||
 LDL-C < 130, hs-CRP < 3 | 21 | 7644.7 | 1 | 1 | 1 | 1 |
 LDL-C < 130, hs-CRP ≥ 3 | 19 | 9429.8 | 1.21 (0.66, 2.22) | 1.31 (0.60, 2.12) | 0.78 (0.42, 1.45) | 0.84 (0.44, 1.60) |
 LDL-C ≥ 130, hs-CRP < 3 | 26 | 8129.7 | 1.13 (0.57, 2.27) | 0.95 (0.46, 1.96) | 1.02 (0.57, 1.83) | 1.07 (0.59, 1.96) |
 LDL-C ≥ 130, hs-CRP ≥ 3 | 29 | 7917.6 | 1.36 (0.69, 2.64) | 1.21 (0.60, 2.42) | 1.17 (0.66, 2.07) | 1.07 (0.59, 1.93) |
Cardiovascular disease | ||||||
 LDL-C < 130, hs-CRP < 3 | 87 | 7644.7 | 1 | 1 | 1 | 1 |
 LDL-C < 130, hs-CRP ≥ 3 | 102 | 9429.8 | 1.32 (0.99, 1.74) | 1.21 (0.90, 1.62) | 1.05 (0.78, 1.41) | 1.07 (0.79, 1.45) |
 LDL-C ≥ 130, hs-CRP < 3 | 127 | 8129.7 | 1.26 (0.91, 1.74) | 1.05 (0.76, 1.47) | 1.24 (0.93, 1.65) | 1.24 (0.92, 1.67) |
 LDL-C ≥ 130, hs-CRP ≥ 3 | 134 | 7917.6 | 1.43 (1.06, 1.92) | 1.26 (0.92, 1.72) | 1.43 (1.08, 1.90) | 1.36 (1.01, 1.83) |
Cardiovascular mortality | ||||||
 LDL-C < 130, hs-CRP < 3 | 22 | 7644.7 | 1 | 1 | 1 | 1 |
 LDL-C < 130, hs-CRP ≥ 3 | 25 | 9429.8 | 1.03 (0.55, 1.95) | 0.88 (0.46, 1.69) | 0.79 (0.44, 1.42) | 0.87 (0.48, 1.58) |
 LDL-C ≥ 130, hs-CRP < 3 | 26 | 8129.7 | 1.21 (0.58, 2.52) | 0.97 (0.46, 2.04) | 0.89 (0.49, 1.57) | 1.00 (0.55, 1.81) |
 LDL-C ≥ 130, hs-CRP ≥ 3 | 29 | 7917.6 | 1.14 (0.57, 2.28) | 0.96 (0.47, 1.96) | 1.01 (0.58, 1.76) | 0.97 (0.54, 1.73) |
All-cause mortality | ||||||
 LDL-C < 130, hs-CRP < 3 | 73 | 2421.3 | 1 | 1 | 1 | 1 |
 LDL-C < 130, hs-CRP ≥ 3 | 68 | 2909.3 | 0.73 (0.41, 1.30) | 0.54 (0.36, 1.21) | 0.70 (0.50, 1.47) | 0.71 (0.51, 1.40) |
 LDL-C ≥ 130, hs-CRP < 3 | 60 | 2293.7 | 0.84 (0.44, 1.59) | 0.62 (0.40, 1.27) | 0.58 (0.41, 1.22) | 0.61 (0.43, 1.36) |
 LDL-C ≥ 130, hs-CRP ≥ 3 | 73 | 2518.7 | 0.78 (0.42, 1.46) | 0.59 (0.39, 1.24) | 0.75 (0.54, 1.55) | 0.74 (0.53, 1.44) |