Variables | Univariate analysis HR (95% CI) | p value | Multivariate analysis HR (95% CI) | p value |
|---|
Age, years | 1.020 (0.973–1.070) | 0.406 | – | – |
Gender | 0.692 (0.226–2.124) | 0.520 | – | – |
Comorbidities | 2.235 (0.728–6.857) | 0.160 | – | – |
Smoking status | 0.676 (0.257–1.778) | 0.428 | – | – |
BMI, kg/m2 | 0.850 (0.721–1.001) | 0.052 |  |  |
cTNI on admission, ng/mL | 4.074 (0.931–17.821) | 0.062 |  |  |
NT-proBNP, ng/mL | 2.727 (0.784–9.492) | 0.115 |  |  |
Ln-OPG, pg/mL | 2.932 (1.532–5.610) | 0.001* | 2.188 (1.102–4.344) | 0.025* |
- Comorbidities indicated hypertension, diabetes
- Data of osteoprotegerin showed skewed distribution and therefore was Ln-transformed before analysis
- The continuous cTNI levels on admission were transformed into the positive and the negative values based on the threshold value of 0.023Â ng/mL. Peak values of NT-proBNP were categorized into the positive and negative values according to the threshold value of 300Â pg/mL in acute phase
- Significant variables (p < 0.15) in univariate Cox regression were further included in the multivariable Cox regression, and only variables with significance were shown in table. Adopted factors: BMI, cTNI on admission, peak values of NT-proBNP, and Ln-OPG
- OPG osteoprotegerin, MACE major adverse cardiac events, AMI acute myocardial infarction, BMI body mass index, cTNI cardiac troponin I, NT-proBNP N terminal pro B type natriuretic peptide, HR hazard ratio, CI confidence intervals
- *p < 0.05 was considered statistically significant
