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Table 2 Linear regression analyses evaluating the relationships between Ln-sclerostin and scores indicating the severity of coronary artery occlusion

From: Association of serum sclerostin and osteoprotegerin levels with the presence, severity and prognosis in patients with acute myocardial infarction

Variables

GENSINI score

GRACE score

Univariate

Multivariate

Univariate

Multivariate

β (SE)

p value

β (SE)

p value

β (SE)

p value

β (SE)

p value

Male

−0.009 (0.104)

0.931

–

–

−0.193 (0.103)

0.065

–

–

Hypertension

−0.048 (0.106)

0.651

–

–

0.021 (0.105)

0.842

–

–

Diabetes

0.116 (0.106)

0.275

–

–

0.349 (0.099)

0.001*

–

–

Smoking status

−0.142 (0.105)

0.181

–

–

−0.174 (0.104)

0.097

–

–

Age, years

0.041 (0.106)

0.699

–

 

0.588 (0.085)

 < 0.001*

0.358 (0.106)

0.001*

BMI, kg/m2

−0.216 (0.103)

0.039*

−0.252 (0.107)

0.021*

−0.246 (0.102)

0.018*

–

–

Ln-FPG, mmol/L

0.165 (0.105)

0.118

–

–

0.280 (0.101)

0.007*

–

–

HDL-C, mmol/L

−0.031 (0.107)

0.773

–

–

−0.124 (0.105)

0.240

–

–

LDL-C, mmol/L

−0.023 (0.104)

0.825

–

–

−0.310 (0.100)

0.003*

–

–

Ln-TG, mmol/L

−0.009 (0.112)

0.936

–

 

−0.386 (0.097)

 < 0.001*

−0.201 (0.092)

0.032*

UA, umol/L

0.171 (0.108)

0.120

–

–

0.027 (0.108)

0.804

–

–

eGFR, mL/min/1.73m2

−0.093 (0.106)

0.381

–

–

−0.485 (0.092)

 < 0.001*

–

–

WBC count, × 10E9

0.052 (0.106)

0.626

–

–

0.025 (0.106)

0.814

–

–

Ln-sclerostin, pg/mL

0.335 (0.100)

0.001*

0.288 (0.108)

0.009*

0.245 (0.102)

0.019*

–

–

  1. Data of sclerostin, triglyceride, and fasting plasma glucose showed skewed distribution and therefore were Ln-transformed before analysis
  2. Significant variables (p < 0.15) in univariate linear regression were further included in the multivariable linear regression, and only variables with significance were shown in table. Adopted variables: BMI, Ln-FPG, UA, and Ln-sclerostin for multivariate regression model of GENSINI score; male, diabetes, smoking status, age, BMI, Ln-FPG, LDL-C, Ln-TG, eGFR and Ln-sclerostin for multivariate regression model of GRACE score
  3. BMI body mass index, FPG fasting plasma glucose, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, TG triglyceride, UA uric acid, eGFR estimated glomerular filtration rate, WBC white blood cell, GRACE the global registry of acute coronary event
  4. *p < 0.05 was considered statistically significant