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Table 2 CTA and combined CTA/CACS versus QCA as the reference standard (≥ 50% stenosis)

From: Diagnostic performance of quantitative coronary artery disease assessment using computed tomography in patients with aortic stenosis undergoing transcatheter aortic-valve implantation

  True positive False positive False negative True negative Sensitivity (%) Specificity (%) PPV (%) NPV (%) Positive LLR Negative LLR Accuracy
Patient based analysis (total n = 100 patients)
Including patients with non-evaluable segments (n = 100 included) 30 62 0 8 100 11.4 32.6 100 1.13 0 38
(95% CI)      88.4–100 5.1–21.3 30.8–34.5 nc 1.04–1.23 nc 28.5–48.3
Excluding patients with non-evaluable segments (n = 16 included, n = 84 excluded) 3 5 0 8 100 61.5 37.5 100 2.60 0 68.8
(95% CI)      29.2–100 31.6–86.1 23.2–54.4 nc 1.31–5.17 nc 41.3–89.0
Combined CTA/CACS (n = 100 included) (If non-evaluable segments present CACS cut-off ≥ 100 = CAD) 30 50 0 20 100 28.6 37.5 100 1.4 0 50
(95% CI)      88.4–100 18.4–40.6 34.1–41.0 nc 1.21–1.62 nc 39.8–60.2
Combined CTA/CACS (n = 100 included) (If non-evaluable segments present CACS cut-off ≥ 400 = CAD) 25 35 5 35 83.3 50.0 41.7 87.5 1.67 0.33 60
(95% CI)      65.3–94.4 37.8–62.2 35.0–48.7 75.3–94.2 1.25–2.21 0.14–0.77 49.7–69.7
Segment based analysis (all coronary segments, n = 1533 segments)
Including non-evaluable segments (n = 1533 included) 41 668 15 809 73.2 54.8 5.8 98.2 1.62 0.49 55.5
(95% CI)      59.7–84.2 52.2–57.3 4.9–6.8 97.2–98.8 1.37–1.92 0.32–0.76 52.9–58.0
Excluding non-evaluable segments (n = 955 included, n = 578 excluded) 19 112 15 809 55.9 87.8 14.5 98.2 4.60 0.50 86.7
(95% CI)      37.9–72.8 85.6–89.9 10.7–19.3 97.4–98.8 3.25–6.49 0.34–0.73 84.4–88.8
Proximal segment based analysis (left main stem + proximal segment of LAD, LCX, RCA)
Including non-evaluable segments (n = 400 included) 15 140 4 241 78.9 63.3 9.7 98.4 2.15 0.33 64.0
(95% CI)      54.4–94.0 58.2–68.1 7.6–12.3 96.2–99.3 1.65–2.81 0.14–0.80 59.1–68.7
Excluding non-evaluable segments (n = 301 included, n = 99 excluded) 8 48 4 241 66.7 83.4 14.3 98.4 4.01 0.40 82.7
(95% CI)      34.9–90.1 78.6–87.5 9.4–21.2 96.4–99.3 2.49–6.46 0.18–0.89 78.0–86.8
Left coronary artery proximal segment based analysis (left main stem + proximal segment of the LAD)
Including all non-evaluable segments (n = 200 included) 3 56 1 140 75.0 71.4 5.1 99.3 2.62 0.35 71.5
(95% CI)      19.4–99.4 64.6–77.6 2.8–9.0 96.2–99.9 1.43–4.82 0.06–1.92 64.7–77.6
Excluding non-evaluable segments (n = 165 included, n = 35 excluded) 3 21 1 140 75.0 87.0 12.5 99.3 5.75 0.29 86.7
(95% CI)      19.4–99.4 80.8–91.7 6.7–22.2 99.29–99.9 2.88–11.49 0.05–1.57 80.5–91.5
LAD vessel based analysis
Including all non- evaluable segments (n = 500 included) 16 207 8 269 66.7 56.5 7.2 97.1 1.53 0.59 57
(95% CI)      44.7–84.4 51.9–61.0 5.4–9.5 95.0–98.4 1.13–2.07 0.33–1.04 52.5–61.4
Excluding non-evaluable segments (n = 338 included, n = 162 excluded) 8 53 8 269 50.0 83.5 13.1 97.1 3.04 0.60 82.0
(95% CI)      24.7–75.4 79.0–87.4 8.0–20.7 95.4–98.2 1.76–5.26 0.37–0.98 77.4–85.9
LCX vessel based analysis
Including non-evaluable segments (n = 500 included) 15 218 4 263 78.9 54.7 6.4 98.5 1.74 0.39 55.6
(95% CI)      54.4–94.0 50.1–59.2 5.1–8.1 96.5–99.4 1.35–2.24 0.16–0.92 51.1–60.0
Excluding non-evaluable segments (n = 299 included, n = 201 excluded) 6 26 4 263 60.0 91.0 18.8 98.5 6.67 0.44 90.0
(95% CI)      26.2–87.8 87.1–94.0 11.0–30.1 96.9–99.3 3.57–12.46 0.21–0.94 86.0–93.1
RCA vessel based analysis
Including all non-evaluable segments (n = 400 included) 10 214 3 173 76.9 44.7 4.5 98.3 1.39 0.52 45.8
(95% CI)      46.2–95.0 39.7–49.8 3.3–6.0 95.5–99.4 1.02–1.90 0.19–1.40 40.8–50.8
Excluding non-evaluable segments (n = 209 included, n = 191 excluded) 5 28 3 173 62.5 86.1 15.2 98.3 4.49 0.44 85.2
(95% CI)      24.5–91.5 80.5–90.5 8.6–25.3 95.9–99.3 2.37–8.49 0.18–1.07 79.6–89.7
  1. CACS coronary artery calcium score, CAD coronary artery disease, CI confidence interval, CTA computed tomography angiography, LAD left anterior descending artery, LCX left circumflex artery, LLR likelihood ratio, nc not computable/calculable, NPV negative predictive value, PPV positive predictive value, QCA quantitative coronary angiography, RCA right coronary artery