Table 2 CTA and combined CTA/CACS versus QCA as the reference standard (≥ 50% stenosis)

Patient based analysis (total n = 100 patients)

Including patients with non-evaluable segments (n = 100 included)

30

62

0

8

100

11.4

32.6

100

1.13

0

38

(95% CI)

88.4–100

5.1–21.3

30.8–34.5

nc

1.04–1.23

nc

28.5–48.3

Excluding patients with non-evaluable segments (n = 16 included, n = 84 excluded)

3

5

0

8

100

61.5

37.5

100

2.60

0

68.8

(95% CI)

29.2–100

31.6–86.1

23.2–54.4

nc

1.31–5.17

nc

41.3–89.0

Combined CTA/CACS (n = 100 included) (If non-evaluable segments present CACS cut-off ≥ 100 = CAD)

30

50

0

20

100

28.6

37.5

100

1.4

0

50

(95% CI)

88.4–100

18.4–40.6

34.1–41.0

nc

1.21–1.62

nc

39.8–60.2

Combined CTA/CACS (n = 100 included) (If non-evaluable segments present CACS cut-off ≥ 400 = CAD)

25

35

5

35

83.3

50.0

41.7

87.5

1.67

0.33

60

(95% CI)

65.3–94.4

37.8–62.2

35.0–48.7

75.3–94.2

1.25–2.21

0.14–0.77

49.7–69.7

Segment based analysis (all coronary segments, n = 1533 segments)

Including non-evaluable segments (n = 1533 included)

41

668

15

809

73.2

54.8

5.8

98.2

1.62

0.49

55.5

(95% CI)

59.7–84.2

52.2–57.3

4.9–6.8

97.2–98.8

1.37–1.92

0.32–0.76

52.9–58.0

Excluding non-evaluable segments (n = 955 included, n = 578 excluded)

19

112

15

809

55.9

87.8

14.5

98.2

4.60

0.50

86.7

(95% CI)

37.9–72.8

85.6–89.9

10.7–19.3

97.4–98.8

3.25–6.49

0.34–0.73

84.4–88.8

Proximal segment based analysis (left main stem + proximal segment of LAD, LCX, RCA)

Including non-evaluable segments (n = 400 included)

15

140

4

241

78.9

63.3

9.7

98.4

2.15

0.33

64.0

(95% CI)

54.4–94.0

58.2–68.1

7.6–12.3

96.2–99.3

1.65–2.81

0.14–0.80

59.1–68.7

Excluding non-evaluable segments (n = 301 included, n = 99 excluded)

8

48

4

241

66.7

83.4

14.3

98.4

4.01

0.40

82.7

(95% CI)

34.9–90.1

78.6–87.5

9.4–21.2

96.4–99.3

2.49–6.46

0.18–0.89

78.0–86.8

Left coronary artery proximal segment based analysis (left main stem + proximal segment of the LAD)

Including all non-evaluable segments (n = 200 included)

3

56

1

140

75.0

71.4

5.1

99.3

2.62

0.35

71.5

(95% CI)

19.4–99.4

64.6–77.6

2.8–9.0

96.2–99.9

1.43–4.82

0.06–1.92

64.7–77.6

Excluding non-evaluable segments (n = 165 included, n = 35 excluded)

3

21

1

140

75.0

87.0

12.5

99.3

5.75

0.29

86.7

(95% CI)

19.4–99.4

80.8–91.7

6.7–22.2

99.29–99.9

2.88–11.49

0.05–1.57

80.5–91.5

LAD vessel based analysis

Including all non- evaluable segments (n = 500 included)

16

207

8

269

66.7

56.5

7.2

97.1

1.53

0.59

57

(95% CI)

44.7–84.4

51.9–61.0

5.4–9.5

95.0–98.4

1.13–2.07

0.33–1.04

52.5–61.4

Excluding non-evaluable segments (n = 338 included, n = 162 excluded)

8

53

8

269

50.0

83.5

13.1

97.1

3.04

0.60

82.0

(95% CI)

24.7–75.4

79.0–87.4

8.0–20.7

95.4–98.2

1.76–5.26

0.37–0.98

77.4–85.9

LCX vessel based analysis

Including non-evaluable segments (n = 500 included)

15

218

4

263

78.9

54.7

6.4

98.5

1.74

0.39

55.6

(95% CI)

54.4–94.0

50.1–59.2

5.1–8.1

96.5–99.4

1.35–2.24

0.16–0.92

51.1–60.0

Excluding non-evaluable segments (n = 299 included, n = 201 excluded)

6

26

4

263

60.0

91.0

18.8

98.5

6.67

0.44

90.0

(95% CI)

26.2–87.8

87.1–94.0

11.0–30.1

96.9–99.3

3.57–12.46

0.21–0.94

86.0–93.1

RCA vessel based analysis

Including all non-evaluable segments (n = 400 included)

10

214

3

173

76.9

44.7

4.5

98.3

1.39

0.52

45.8

(95% CI)

46.2–95.0

39.7–49.8

3.3–6.0

95.5–99.4

1.02–1.90

0.19–1.40

40.8–50.8

Excluding non-evaluable segments (n = 209 included, n = 191 excluded)

5

28

3

173

62.5

86.1

15.2

98.3

4.49

0.44

85.2

(95% CI)

24.5–91.5

80.5–90.5

8.6–25.3

95.9–99.3

2.37–8.49

0.18–1.07

79.6–89.7