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Fig. 6 | BMC Cardiovascular Disorders

Fig. 6

From: H3K9me2 regulation of BDNF expression via G9a partakes in the progression of heart failure

Fig. 6

Silencing of BDNF partially reverses the effect of sh-G9a on alleviating myocardial injury in rats with HF by inhibiting the TrkB signaling pathway. A The protein expression BDNF and the extent of TrkB phosphorylation in rat myocardial tissues by Western blot (Uncropped protein blots are provided in the Additional file 1). B Echocardiographic assessment of cardiac function in rats. C Myocardial damage in rats examined using TTC staining. D The pathological changes in the myocardial tissues of rats measured using HE staining. E Detection of CK-MB and cTnI in the serum of rats measured using ELISA. F Changes of inflammatory factors IL-6 and TNF-α in rats detected by ELISA. G Apoptosis in myocardial tissues of rats measured using TUNEL assay. H Changes of α-SMA in myocardial tissues of rats by immunohistochemistry. Data are expressed as mean ± SD (n = 6). Three or more groups were compared by one-way or two-way ANOVA and Tukey's post hoc test. *p < 0.05, **p < 0.01

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