Table 3 Significantly enriched signaling pathways associated to the validated differentially expressed miRNAs
From: MicroRNA profile of circulating CD4+ T cells in aged patients with atherosclerosis obliterans
KEGG pathway | FDR | Number of miRNAs | Putative target genes |
|---|---|---|---|
Adherent junction | 8.28 × 10−3 | 2 (miR-142-3p; miR-150) | ACTN1, ACTN4, PVRL2, RAC1, TCF4, WASL |
Protein digestion and absorption | 9.73 × 10−3 | 1 (miR-29b) | COL15A1, COL2A1, COL3A1, COL4A1, COL4A5, COL4A6 |
Focal adhesion | 0.012 | 3 (miR-29b; miR-142-3p; miR-150) | ACTN1, ACTN4, COL2A1, COL3A1, COL4A1, COL4A5, COL4A6, ELK1, RAC1 |
Circadian rhythm | 0.035 | 3(miR-29b; miR-142-3p; miR-150) | ARNTL, PER3, RORB |
ECM-receptor interaction | 0.035 | 1 (miR-29b) | COL2A1, COL3A1, COL4A1, COL4A5, COL4A6 |