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Table 3 Significantly enriched signaling pathways associated to the validated differentially expressed miRNAs

From: MicroRNA profile of circulating CD4+ T cells in aged patients with atherosclerosis obliterans

KEGG pathway FDR Number of miRNAs Putative target genes
Adherent junction 8.28 × 10−3 2 (miR-142-3p; miR-150) ACTN1, ACTN4, PVRL2, RAC1, TCF4, WASL
Protein digestion and absorption 9.73 × 10−3 1 (miR-29b) COL15A1, COL2A1, COL3A1, COL4A1, COL4A5, COL4A6
Focal adhesion 0.012 3 (miR-29b; miR-142-3p; miR-150) ACTN1, ACTN4, COL2A1, COL3A1, COL4A1, COL4A5, COL4A6, ELK1, RAC1
Circadian rhythm 0.035 3(miR-29b; miR-142-3p; miR-150) ARNTL, PER3, RORB
ECM-receptor interaction 0.035 1 (miR-29b) COL2A1, COL3A1, COL4A1, COL4A5, COL4A6
  1. KEGG: Kyoto Encyclopedia of Genes and Genomes; ECM: Extracellular matrix; FDR: False discovery rate