Table 1 Demographics and risk factors of each region (median [IQR] or frequency (percentages))

Patient related

Age*

56.94 [49.75, 63.50]

55.68 [46.95, 63.70]

58.19 [49.41, 65.54]

54.27 [46.59, 62.39]

54.84 [46.10, 63.44]

52.02 [45.51, 60.33]

53.26 [46.28, 60.55]

55.31[47.29, 63.50]

Female

732 (46.9)

6559 (46.1)

4689 (48.1)

2118 (46.2)

368 (43.9)

2113 (56.0)

1436 (42.1)

18,015 (47.2)

BMI

23.51 [21.33, 25.80]

23.44 [21.11, 25.78]

22.89 [20.76, 25.00]

22.60 [20.70, 24.84]

22.37 [20.08, 24.57]

22.51 [20.50, 24.69]

22.86 [20.71, 25.00]

23.03 [20.82, 25.31]

BSA(m²)*

1.67 [1.55, 1.81]

1.68 [1.55, 1.81]

1.62 [1.50, 1.75]

1.64 [1.53, 1.76]

1.59 [1.48, 1.71]

1.56 [1.46, 1.68]

1.66 [1.55, 1.78]

1.64 [1.53, 1.78]

Diabetes mellitus

131 (8.4)

1046 (7.4)

732 (7.5)

271 (5.9)

73 (8.7)

162 (4.3)

152 (4.5)

2567 (6.7)

Hypertension

447 (28.7)

4388 (30.9)

2951 (30.3)

1090 (23.8)

180 (21.5)

439 (11.6)

655 (19.2)

10,150 (26.6)

eGFR*

91.98 [76.84, 102.39]

88.59 [73.38, 100.35]

90.66 [75.20, 101.65]

95.09 [79.86, 105.88]

87.87 [70.70, 102.00]

94.09 [79.63, 104.95]

86.79 [69.40, 102.36]

90.70[74.69, 102.22]

CKD

20 (1.3)

874 (6.1)

151 (1.5)

51 (1.1)

11 (1.3)

16 (0.4)

10 (0.3)

1133 (3.0)

Dialysis*

1 (0.1)

69 (0.5)

29 (0.3)

12 (0.3)

1 (0.1)

4 (0.1)

1 (0.0)

117 (0.3)

COPD*

14 (0.9)

106 (0.7)

72 (0.7)

83 (1.8)

9 (1.1)

31 (0.8)

49 (1.4)

364 (1.0)

Previous stroke*

31 (2.0)

557 (3.9)

496 (5.1)

292 (6.4)

51 (6.1)

93 (2.5)

106 (3.1)

1626 (4.3)

Extracardiac arteriopathy

21 (1.3)

270 (1.9)

390 (4.0)

145 (3.2)

18 (2.1)

6 (0.2)

47 (1.4)

897 (2.4)

Heart related

NYHA III or IV*

1261 (80.8)

5804 (40.8)

5042 (51.7)

2331 (50.8)

514 (61.3)

2846 (75.4)

2173 (63.7)

19,971 (52.4)

Arrhythmia

523 (33.5)

1719 (12.1)

2989 (30.7)

1287 (28.1)

298 (35.5)

1267 (33.6)

858 (25.2)

8941 (23.4)

Critical status*

16 (1.0)

53 (0.4)

80 (0.8)

21 (0.5)

14 (1.7)

29 (0.8)

22 (0.6)

235 (0.6)

Previous myocardial infarction

41 (2.6)

427 (3.0)

127 (1.3)

90 (2.0)

32 (3.8)

31 (0.8)

41 (1.2)

789 (2.1)

Previous cardiac surgery*

42 (2.7)

1031 (7.3)

422 (4.3)

229 (5.0)

58 (6.9)

90 (2.4)

109 (3.2)

1981 (5.2)

LVEF*

LVEF ≥ 50%

1407 (90.2)

13,429 (94.5)

8633 (88.6)

4094 (89.3)

742 (88.4)

3049 (80.8)

2869 (84.1)

34,223 (89.8)

35% ≤ LVEF < 50%

136 (8.7)

692 (4.9)

992 (10.2)

457 (10.0)

89 (10.6)

641 (17.0)

518 (15.2)

3525 (9.2)

LVEF < 35%

17 (1.1)

96 (0.7)

119 (1.2)

36 (0.8)

8 (1.0)

83 (2.2)

24 (0.7)

383 (1.0)

Left main stenosis*

27(1.7)

194(1.4)

299(3.1)

74(1.6)

36(4.3)

54(1.4)

43(1.3)

727(1.9)

AS

427 (27.4)

2606 (18.3)

2352 (24.1)

1106 (24.1)

221 (26.3)

1260 (33.4)

885 (25.9)

8857 (23.2)

Severe AI

230 (14.7)

742 (5.2)

1663 (17.1)

862 (18.8)

165 (19.7)

757 (20.1)

749 (22.0)

5168 (13.6)

MS

484 (31.0)

2764 (19.4)

3062 (31.4)

1480 (32.3)

331 (39.5)

2049 (54.3)

1099 (32.2)

11,269 (29.6)

Severe MI

572 (36.7)

1015 (7.1)

2477 (25.4)

1392 (30.3)

244 (29.1)

877 (23.2)

544 (15.9)

7121 (18.7)

Severe TI*

185 (11.9)

368 (2.6)

1003 (10.3)

512 (11.2)

107 (12.8)

447 (11.8)

205 (6.0)

2827 (7.4)

RHD

547 (35.1)

4504 (31.7)

4790 (49.2)

2218 (48.4)

345 (41.1)

2137 (56.6)

1526 (44.7)

16,067 (42.1)

Endocarditis

83 (5.3)

439 (3.1)

317 (3.3)

194 (4.2)

54 (6.4)

65 (1.7)

99 (2.9)

1251 (3.3)

Operation related

Non-elective surgery*

17 (1.1)

225 (1.6)

91 (0.9)

73 (1.6)

17 (2.0)

19 (0.5)

70 ( 2.1)

512 ( 1.3)

Aortic aneurysm operation*

10(0.6)

317(2.2)

359(3.7)

198(4.3)

50(5.9)

115(3.0)

343(10.0)

1392(3.7)

CABG*

155 (9.9)

2219 (15.6)

1097 (11.3)

674 (14.7)

141 (16.8)

181 (4.8)

209 ( 6.1)

4676 (12.3)