CRP levels are significantly associated with CRP genotype and estrogen use in The Lifestyle, Biomarker and Atherosclerosis (LBA) study

Table 3 Univariate and adjusted multiple linear regression models in 780 individuals of the LBA cohort

	rs3091244 (−286C>T>A)			rs1800947 (+1059G>C)			rs1130864 (+1444C>T)			rs1205 (+1846G>A)
	Unstand b	Stand Beta	p	Unstand b	Stand Beta	p	Unstand b	Stand Beta	p	Unstand b	Stand Beta	p
Univariate models¹
Genotype	0.238	0.158	< 0.001	− 0.476	− 0.147	< 0.001	0.214	0.139	< 0.001	− 0.230	− 0.149	< 0.001
Multiple models²
BMI	0.099	0.320	< 0.001	0.100	0.324	< 0.001	0.098	0.318	< 0.001	0.099	0.321	< 0.001
LDL	− 0.046	− 0.032	0.354	− 0.049	− 0.033	0.326	− 0.044	− 0.030	0.377	− 0.043	− 0.029	0.388
Triglycerides(ln)	0.478	0.187	< 0.001	0.469	0.183	< 0.001	0.482	0.188	< 0.001	0.483	0.189	< 0.001
Insulin(ln)	0.001	0.000	0.991	0.000	0.000	0.995	0.010	0.005	0.885	0.007	0.004	0.916
Systolic BP	− 0.003	− 0.032	0.443	− 0.001	− 0.013	0.760	− 0.003	− 0.032	0.437	− 0.003	− 0.033	0.425
Sex (F/M)	− 0.175	− 0.080	0.051	− 0.196	− 0.089	0.030	− 0.155	− 0.071	0.083	− 0.166	− 0.076	0.063
Estrogen use (No/yes)	0.713	0.263	< 0.001	0.718	0.265	< 0.001	0.718	0.265	< 0.001	0.718	0.265	< 0.001
Genotype	0.180	0.120	< 0.001	− 0.424	− 0.132	< 0.001	0.163	0.106	< 0.001	− 0.199	− 0.130	< 0.001

The C-reactive protein [CRP(ln)] was regressed on BMI, LDL, triglycerides(ln), insulin(ln), systolic blood pressure, sex, estrogen use and genotypes (rs3091244, rs1800947, rs1130864, rs1205). Abbreviations (unit) used: BMI = Body Mass Index (kg/m²); LDL = Low density lipoprotein (mmol/L); Tri = Triglycerides (mmol/L); Ins = Insulin (mU/L); BP = Blood pressure (mmHg); F/M = Female/Male; Unstand b = Unstandardized beta-coefficient; Stand Beta = Standardized beta-coefficient
¹In the univariate models, CRP(ln) was regressed on the genotype, separately for each genotype
²In the multiple models, CRP(ln) was regressed on BMI, LDL, triglycerides(ln), insulin(ln), systolic blood pressure, sex, estrogen use and genotype, separately for each genotype. The adjusted R² for the models were 0.250, 0.253, 0,247, and 0.253 for rs3091244, rs1800947, rs1130864, and rs1205, respectively

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