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Table 2 Clinical characteristics of CAS after CABG

From: Perioperative coronary artery spasm after off-pump coronary artery bypass grafting in the non-manipulated coronary artery

Patient

Year of publication

Symptoms and preoperative findings

Evidence of postoperative CAS

Treatment

Patient outcome

1

1981 [8]

Exertional angina, 90% obstruction in the left main coronary artery

Inferior ST-segment elevation, hypotension

Intravenous NTG, IABP, nifedipine

Died

2

1981 [8]

Exertional and variant angina, 80% obstruction in the left anterior descending artery

Inferior ST-segment elevation, hypotension, sinus bradycardia

Intravenous NTG, IABP

Died

3

1981 [8]

Variant angina, 95% obstruction of LADA

Inferior ST-segment elevation, hypotension

Intravenous NTG, nifedipine

Died

4

1981 [8]

Rest and exertional angina, 90% obstruction in left main coronary artery

Inferior ST-segment elevation, hypotension, ventricular tachycardia

NTG, nifedipine

Recovery, but not reporting the discharge conditions

5

1981 [8]

Exertional angina, 99% obstruction of LADA, 90% obstruction of LCx

Inferior ST-segment elevation, hypotension, and atrioventricular block

NTG, nifedipine, IABP

Recovery, but not reporting the discharge conditions

6

1981 [8]

Rest and exertional angina, 90% obstruction of LADA, 70% obstruction of diagonal artery

Inferior ST-segment elevation, hypotension, and atrioventricular block

NTG, nifedipine, phentolamine

Recovery, but not reporting the discharge conditions

7

2007 [23]

Recurrent angina, underwent PTCA of the LCx and RCA; critical lesions of LCx and RCA

ST-segment elevation over leads II, III and aVF by ECG

Verapamil and NTG into the vein grafts by intracoronary injection, followed by i.v. infusion of nitroprusside and NTG

Discharged on day 10 uneventfully after surgery

8

2007 [23]

Exertional angina, left main coronary artery stenosis

ECG showed ST-segment elevation on lead III, short-run ventricular tachycardia

IABP and infusion of inotropic agent

Discharged on day 9 uneventfully with good clinical conditions

9

2007 [23]

Chest tightness, underwent PTCA with RCA stenting; total LAD occlusion and in-stent restenosis of RCA

ECG showed Q waves over leads II, III, and aVF, as well as inverted T wave over V4-V6

ECMO, intracoronary and systemic administration of NTG and nitroprusside; bolus injection of epinephrine and IABP insertion

Discharged with no complications on day 20 after surgery

10

2003 [26]

underwent PTCA with stenting of Cx and RCA; pre-stent sub-occlusive lesion of the RCA

ST segment elevation in lead D3, reduction of R wave in lead aVF, D3 and ST segment depression in lead V3-6, D1 and AVL; a new akynetic area in inferior left ventricular wall

Insertion of an IABP and intravenous NTG infusion

Discharged on 12 after surgery in good clinical conditions; survived in the 3-year follow-up

11

1999 [22]

Exertional angina, hypertension and previous myocardial infarction; angiogram revealed a mildly impaired ventricular contractility, a 90% stenosis on the LAD involving the first diagonal branch, and a 90% proximal stenosis in the RCA

Antero-lateral myocardial ischemia, elevation of blood pressure (33/30 mmHg) associated with ST-segment depression

Diltiazem, glyceryl trinitrate; intracoronary infusion of nitrates and verapamil

Discharged on day 7 after surgery

12

2013 [24]

Sudden bradycardia, hypertension; stenosis in the proximal anterior descending branch of LCA; 90% stenosis in the first and second diagonal branch, 90% stenosis of obtuse marginal branch and high lateral artery

ST segment elevation

Diltiaze, NTG, NCR, IABP

Discharged with no complications on day 74after surgery

13

2007 [25]

Recurrent angina; 60% in-stent stenosis with extension into the left main and ostial LCx

Minimal spasm in the radial artery graft, worsening of the native LAD lesion, and diffuse spasm of the native RCA

IABP, dobutamine and milrinone

Discharged on day 8 after aftery

14

2005 [27]

Frequent angina; 90% stenosis in left main trunk and 75% stenosis of posterolateral brunch of RCA

CAS was not observed, but was speculated based on ECG and hemodynamic deterioration. ST segment depression in precordial leads on ECG, ST-segment elevation in II, III and aVF leads

Diltiazem, vasodilator agents such as nicorandil, verapamil, papaverine and NTG; IABP

Not reported

15

2010 [4]

Unstable angina; 80% obstruction of proximal left AIA

Extensive anterior ischemia after ECG, ST segment elevation

Intracoronary vasodilators

Discharged on 13 after surgery

16

2010 [21]

Chronic stable angina pectoris and hypertension; 90% stenosis on distal left main coronary artery

ST segment depression, hypertension,

Intracoronary infusion of NTG, oral medication of nicorandil

Discharged on 15 after surgery

17

1990 [28]

Angina and chest pain at rest, nocturnal pain; multiple stenosis in RCA, Cx and LAD

A supranodal rhythm and an incomplete right bundle branch block, with ST elevation in V3 and V4

GTN, intravenous nifedipine, dobutamine

Free of angina in the 1-year follow-up

  1. LAD left anterior descending artery; NTG nitroglycerin; PTCA percutaneous coronary angioplasty; LCx left circumflex; RCA right coronary artery; aVF augmented voltage foot; IABP intraaortic balloon pump; coronary angiography; LCA left coronary artery; NCR nicorandil; ECG electrocardiogram; AIA anterior interventricular artery; GTN glyceroltrinitrate