Table 1 MRI characteristics of the diabetic mini-pigs
Characteristics | Modeling 0Â M | Modeling 1.5Â M | Modeling 3Â M | Modeling 4.5Â M | Modeling 6Â M | P values (0 vs 6Â M) |
|---|---|---|---|---|---|---|
LVEDV (mL/m2) | 28.1 (25.2, 30.2) | 28.7 (26.4, 29.8) | 27.9 (27.1, 31.3) | 26.4 (26, 32.7) | 28.7 (26.5, 30.7) | 0.694 |
LVESV (mL/m2) | 12.9 (9.1, 16.6) | 12.1 (9.7, 15.9) | 12.8 (10.1, 15.6) | 12.4 (9.5, 17.2) | 13.1 (10.2, 16.8) | 0.871 |
LVEF (%) | 59.9 (57.2, 64.2) | 61.1 (58.3, 66.9) | 60.8 (55.6, 68.2) | 61.5 (58.6, 66.1) | 61.8 (58.4, 67.6) | 0.568 |
LVM (g/m2) | 24.5 (23.4, 26.7) | 26.9 (24.9, 27.3) | 34.5 (31.9, 35.6) | 37.9 (36.1, 38.5) | 42.7 (41.4, 44.6) |  < 0.001* |
LV remodeling index | 0.8 (0.7, 0.9) | 0.9 (0.8, 1.0) | 1.0 (1.0, 1.1) | 1.4 (1.3, 1.4) | 1.7 (1.6, 1.7) |  < 0.001* |
Native T1 (ms) | 1005.5 (992.6, 1010.7) | 1006.7 (990.5, 1012.4) | 1014.7 (1001.8, 1020.5) | 1020.2 (1007.3, 1025.8) | 1028.7 (1015.5, 1035.6) | 0.041* |
EAT (ml) | 16.1 (14.5, 18.2) | 17.8 (16.4, 19.7) | 16.5 (16.2, 18.9) | 19.3 (18.4, 22.9) | 24.6 (20.8, 26.9) | 0.020* |
ECV (%) | 21.4 (20.2, 23.9) | 21.8 (21.1, 24.2) | 23.4 (23.3, 26.2) | 25.9 (24.8, 27.8) | 28.9 (26.7, 30.3) | 0.011* |
LVGRS (%) | 57.9 (56.7, 60.9) | 62.3 (58.1, 62.3) | 59.7 (56.3, 60.3) | 60.7 (56.2, 61.2) | 58.2 (55.3, 62.0) | 1.000 |
LVGCS (%) | − 22.9 (− 22.3, − 23.8) | − 22.1 (− 20.2, − 23.1) | − 23.9 (− 23.4, − 24.2) | − 22.2 (− 21.2, − 23.3) | − 22.1 (− 20.8, − 24.5) | 0.672 |
LVGLS (%) | − 22.8 (− 21.4, − 23.9) | − 22.3 (− 21.9, − 24.8) | − 20.2 (− 19.8, − 22.3) | − 18.7 (− 18.5, − 21.0) | − 17.4 (− 17.2, − 19.2) | 0.008* |