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Table 4 Incremental prognostic utility of LA mechanics compared with Mayo criteria 2004 and 2012

From: Prognostic value of left atrial mechanics in cardiac light-chain amyloidosis with preserved ejection fraction: a cohort study

Variables

Mayo 2004

Mayo 2012

Reservoir function

Conduit function

Booster pump function

Total strain

Total strain rate

Passive strain

Passive strain rate

Active strain

Active strain rate

LA stiffness index

Discrimination (95% CI)

 C-statistic

0.62 (0.54–0.7)

0.66 (0.61–0.72)

0.68 (0.60–0.76)

0.67 (0.58–0.77)

0.65 (0.57–0.74)

0.65 (0.56–0.74)

0.68 (0.59–0.77)

0.67 (0.58–0.76)

0.69 (0.61–0.78)

   

0.70 (0.64–0.76)

0.72 (0.67–0.78)

0.68 (0.62–0.73)

0.69 (0.63–0.76)

0.75 (0.71–0.81)

0.76 (0.70–0.81)

0.72 (0.66–0.77)

Absolute IDI

–

–

0.135 (0.040–0.280) p < 0.0001

0.08 (0.001–0.227) p = 0.03

0.061 (0.000–0.166) p = 0.05

0.027 (− 0.006–0.117) p = 0.159

0.116 (0.011–0.278) p < 0.0001

0.095 (0.001–0.236) p = 0.04

0.071 (0.004–0.175) p = 0.02

   

0.105 (0.001–0.299) p = 0.036

0.134 (0.000–0.196) p = 0.05

0.077 (− 0.020–0.172) p = 0.144

0.021 (− 0.017–0.194) p = 0.219

0.063 (0.009–0.188) p = 0.02

0.046 (0.027–0.208) p = 0.018

0.062 (0.021–0.263) p = 0.009

Category-free NRI index

–

–

0.232 (0.046–0.494) p < 0.0001

0.273 (− 0.030–0.512) p = 0.06

0.189 (− 0.050–0.415) p = 0.179

0.122 (− 0.103–0.346) p = 0.209

0.241 (0.001–0.480) p = 0.04

0.208 (− 0.035–0.522) p = 0.09

0.364 (0.000–0.572) p = 0.05

   

0.161 (0.034–0.387) p = 0.002

0.233 (− 0.069–0.580) p = 0.078

0.059 (− 0.251–0.401) p = 0.647

0.039 (− 0.276–0.360) p = 0.567

0.290 (0.006–0.413) p = 0.017

0.277 (0.002–0.567) p = 0.039

0.257 (0.026–0.434) p = 0.006

Goodness of fit

LR test

–

–

p = 0.000124

p = 0.002329

p = 0.004477

p = 0.03902

p = 0.000408

p = 0.00152

p = 0.003526

   

p = 0.02669

p = 0.002943

p = 0.08036

p = 0.05197

p = 0.005125

p = 0.002119

p = 0.01461

BIC

304.2324

134.9205

293.1057

277.5958

299.7637

282.6064

295.3481

276.8124

297.6163

   

135.2916

112.6833

137.4963

118.4258

131.9916

112.026

133.1287

  1. For each index, the upper line represents LA mechanics + Mayo criteria 2004 and the lower line represents LA mechanics + Mayo criteria 2012
  2. BIC Bayes information criterion, CI confidential interval, IDI integrated discrimination index, LA left atrial, NRI net reclassification improvement