Peak oxygen uptake is a strong prognostic predictor for pulmonary hypertension due to left heart disease

Table 3 Cox regression analysis for all-cause death in patients with PH-LHD

	Univariate analysis				Multivariate-Adjusted Analysis*
Variables	HR	95% CI		P-value	HR	95% CI		P-value
Variables	HR	Lower	Higher	P-value	HR	Lower	Higher	P-value
Age, years	1.052	1.001	1.105	0.044
6 MWD, m	0.996	0.993	0.999	0.008
NT-proBNP**, pg/mL	2.341	1.407	3.894	0.001
Cpc-PH/Ipc-PH	0.350	0.123	0.997	0.049
Exercise Time, s	0.991	0.987	0.996	< 0.001
Peak VO₂/kg, mL/min/kg	0.532	0.411	0.689	< 0.001	0.487	0.359	0.660	< 0.001

PH-LHD, pulmonary hypertension due to left heart disease; 6MWD, 6-min walk distance; Cpc-PH, post- and precapillary pulmonary hypertension; Ipc-PH, isolated postcapillary pulmonary hypertension; VO₂, oxygen consumption. * According to the rule of statistical power and Bonferroni correct, 6WMD, exercise time and Peak VO₂/kg were finally reserved in the multivariate-adjusted analysis. ** NT-proBNP was log transformed

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