Peak oxygen uptake is a strong prognostic predictor for pulmonary hypertension due to left heart disease

Table 2 Comparison of the CPET parameters between survivors and nonsurvivors

	Nonsurvivors (n = 17)	Survivors (n = 72)	P-value*
Exercise capacity
Workload, watts	34.4 ± 17.0	59.2 ± 33.5	0.004
Peak O₂ pulse, ml/beat	5.3 (3.5, 6.7)	6.2 (5.1, 8.0)	0.041
Exercise time, s	170.0 (110.0,220.0)	249.0 (181.5,290.0)	0.001
Peak VO₂, mL/min/kg	9.4 ± 2.2	12.9 ± 3.3	< 0.001
Ventilatory and gas exchange efficiency
Lowest VE/VCO₂	43.2 (36.0, 46.0)	37.4 (33.1, 43.4)	0.026
VE/VCO₂ slope	36.4 (31.4, 51.3)	32.5 (28.8, 38.0)	0.113
Peak VE/VCO₂	46.5 (38.1, 49.2)	38.1 (34.5, 45.7)	0.022
Peak P_ET CO₂, mmHg	31.3 ± 6.4	33.8 ± 6.7	0.179
Peak VO₂/VE, mL/L	22.7 ± 5.3	25.4 ± 5.7	0.082
OUEP, mL/L	25.8 ± 4.9	28.5 ± 4.9	0.042
OUES	1.0 ± 0.3	1.3 ± 0.5	0.009

The data are shown as the mean ± SD or median (quartile range). CPET, cardiopulmonary exercise test; Cpc-PH, post- and precapillary pulmonary hypertension; Ipc-PH, isolated postcapillary pulmonary hypertension; VO₂, oxygen consumption; VE/VCO₂, minute ventilation/carbon dioxide output; P_ET CO₂, end-tidal partial pressure of CO₂; VO₂/VE, oxygen uptake/minute ventilation; OUEP, oxygen uptake efficiency plateau; OUES, oxygen uptake efficiency slope. * When the Bonferroni method was employed for correcting for the significance level for 11 comparisons made in this study, the adjusted significant level was 0.004

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